Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 332 for “"post-translational modifications"”.
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NEUROPROTECTIVE THERAPIES CENTRED ON POST-TRANSLATIONAL MODIFICATIONS BY SUMOYLATION
… that improve functional recovery in post-ischemic patients (i.e. regenerative therapies). The restricted success of such a massive research investment demands a re-evaluation of the pathobiology of ischemic brain injury and a subsequent adjustment of therapeutic approaches. While …
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Physical consequences of natural and synthetic post-translational modifications
Protein modifications endow diverse chemical and biological functions. Development of new modifications, control over extant, and the appreciation of their consequences promises to unveil the mechanisms of disease, provide avenues of therapeutic development, and provide insight into intricacies of …
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Coordinated of Post-Translational Modifications of Yeast Transcriptional Activator Gcn4
… regulated after binding DNA through coordinated post-translational modifications.
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Post-translational modifications of c-FLIP: opportunities for therapeutic intervention
FLIP is an anti-apoptotic protein found overexpressed in a wide variety of cancers and is associated with drug resistance and poor prognosis. It acts by inhibiting the membrane-proximal steps of death receptor-mediated apoptosis at the death inducing signalling complex (DISC), but also has roles in …
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Post-translational modifications regulate β2-Adrenoceptor signaling in cardiac myocytes
… all of which are tightly regulated by post-translational modifications of the C-terminal region of β2AR. Over past decades, these modifications have been extensively characterized biochemically in fibroblasts, such as phosphorylation by PKA (serines 261, 262, 345 and 346) and G protein …
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Post-translational modifications catalyzed by RiPP and RiPP-adjacent enzymes
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are, as their name suggests, constructed from ribosomal peptides. The scope of biosynthetic reactions utilized by Nature to transform these peptides into structurally fascinating natural products is astounding. Leveraging …
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Post-translational modifications of methyl-coenzyme m reductase in methanosarcina acetivorans
… Additionally, MCR contains several unusual post-translationally modified (PTM) amino acids near its active site. Although some of these modifications are widely conserved, others are rarely observed. However, all MCRs characterized to date have at least three post-translationally modified …
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METABOLISM-COUPLED PROTEIN POST-TRANSLATIONAL MODIFICATIONS IN C. ELEGANS AND MAMMALIAN MODELS
… way of product inhibition of enzymes and protein post-translational modifications (PTMs). PTMs are chemical modifications that occur on proteins after their synthesis, enabling rapid and often reversible functional responses to cellular and environmental changes. Most of the hundreds of known PTMs …
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Novel Approaches for the Measurement of Unusual Post-Translational Modifications in Neuropeptides
Other PTMs, such as the transformation of L-amino acid residues to the D-configuration, do not result in a measurable mass change. Capillary electrophoresis combined with mass spectrometry is used to identify cells containing a D-amino acid-containing peptide found in Aplysia. These cells are then …
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Development and Application of Proteomic Technologies for the Analysis of Post-Translational Modifications
Post-translational modifications represent a rapid and dynamic means for diversifying the chemistry of the ~20 ribosomally coded amino acids. As such, they provide an ideal mechanism for promoting cellular adaptability by facilitating the tuning of protein interactions and functions in response to …
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Method development for the comprehensive analysis of post translational modifications by mass spectometry
… within cells are often regulated by different post-translational modifications (PTM). As PTMs add or subtract a specific mass difference to a protein, mass spectrometry becomes very amenable for modification analysis. These modifications have conventionally been monitored by fragmenting the …
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Development of a novel liquid chromatography based tool to study post-translational modifications
There are many tools available for the study of post-translational modifications. The majority of these tools is specific towards the individual modification and involves separation of modified proteins from non-modified ones. The drawback of using a modification specific method is that there is a …
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Modifying N-linked glycosylation in tobacco to produce human-type post-translational modifications
… or yeasts. However, plants do not perform post translation protein modification in the same manner as mammalian cells, most critically in terms of N-linked glycosylation. This can impact both protein functionality and stability, key for human therapeutics intended for production in plants. …
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Mechanism of regulation of human RAD51 recombinase through post translational modifications & mediator proteins
… the BRCA2 recombination mediator, and a host of post translational modifications, namely phosphorylation. The mechanism and biochemical implications of these regulatory processes have not been satisfactorily evaluated in-vitro. This work characterizes the interaction between RAD51 and the BRCA2 …
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Analyzing Post Translational Modifications on Yeast Core Histones Using Fourier Transform Mass Spectrometry
"In the end, a ""Middle-Down"" mass spectrometry approach has also been developed to study the kinetics of autoacetylation for the histone acetyltransferase, p300."
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Post-translational modifications of SEL24K from salmon eggs and ZPA from Xenopus laevis eggs
<p>Post-translational modifications (PTMs) of proteins play significant roles in regulation of biological activities and signal transduction. Examining their diversity is critical for understanding the mechanisms of cellular regulations. Among the various techniques employed for identification of …
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Examining Post-Translational Modifications In Alpha-Synuclein Through Semi-Synthesis And Single Molecule Spectroscopy
… including Parkinson’s disease. A variety of post-translational modifications (PTMs) are known or hypothesized to affect both the function of αS and its propensity to form fibrils. In this work, we introduce PTMs of interest along with fluorescent probes into αS through semi-synthesis, …
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