Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"post-translation modifications"”.
-
Functional analysis of the histone variant H2A.Z during lineage commitment
… the deposition of repressive histone modifications, as well as a potential connection between H2A.Zub and DNA damage. Therefore, ubiquitin may serve as a binding platform for subsequent recruitment of chromatin-associated factors. These data suggest a mechanism by which …
-
Environmental Signaling through the Target of Rapamycin Complex 1 (TORC1) and the Regulation of Epigenetic Mechanisms
… gene regulatory process through altered histone post-translation modifications, changes in chromatin structure, and docking of chromatin regulatory complexes. Yet, despite preliminary studies suggesting that TORC1 affects epigenetic mechanisms, including histone H3 lysine 56 acetylation …
-
Novel strategies to increase Sirtuin-1 activity in aortic aneurysm
… (Glrx), an enzyme that prevents oxidative modifications on SirT1, was able to restore SirT1 activity in liver cells. OBJECTIVES: The goal of this study is to enhance SirT1 activity in aortas and VSM cells in a mouse model of AA (hypomorphic fibrillin-1 mice, Fbn1mgR/mgR). This thesis will …
-
Biomedical applications for bacteriocins in infection and oncology
… called bacteriocins. They are characterized by post-translation modifications resulting in the presence of unusual amino acid residues such as dehydroalanine (Dha), dehydrobutyrine (Dhb) and lanthionine/ methyllanthionine. Interest in using bacteriocins as alternative therapeutics in multiple …
-
Synthesis And Application Of Atp Analogs For Phosphorylation-Dependent Kinase-Substrate Crosslinking
<p>Phosphorylation is an important post-translational modification that plays a key role in a variety of signaling cascades and cellular functions. Kinases phosphorylate protein substrates in a highly regulated manner and are promiscuous. Understanding kinase-substrate specificity has been …
-
Metabolite biosynthetic enzymes: catalysis, substrate specificity and protein engineering
… of a single residue. Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a major class of natural products produced by secondary metabolism. A precursor peptide is translated by the ribosome and tailoring enzymes perform multiple post-translation modifications on said …
-
Bayesian Methods for Spatial Proteomics
… Carlo algorithms are employed to sample from the posterior distribution of localisation probabilities. This is the basis for quantifying uncertainty in protein-organelle associations. This Bayesian approach has several limitations, for example it still relies on marker proteins. This precludes …
-
Bioinformatic methods for the analysis of genetic variability and regulation
… between the epigenome, particularly histone post-translation modifications (PTM), and regulation of functional genomic elements. Histone marks control much of the workings of the genome. However, it remains unclear how different histone PTM combine within individual nucleosomes to encode …