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Showing 1 to 20 of 23 for “"post-synthetic modification"”.
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Three-Way Chemoselectivity Switching through Coupled Equilibria in Complex System and Post-synthetic Modification of Cyclobenzoins
Everything around us is complex systems, including ant-hills, human economies, climate systems, nervous systems, and human beings. In order to understand complex systems often requires cross-disciplinary techniques that merge the knowledge from different fields such as mathematics, physics, …
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A 'Toolkit' of Small Molecules for Polymer Assembly and Post-Synthetic Modification Using 'Click' and Photoactive Chemistries
… of a 'toolkit' approach to polymer assembly and modification. Variations and extensions upon the 'toolkit' are detailed in order to give a sense of the future possibilities of this approach.
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Chemical synthesis of DNA and RNA containing thio-substituted bases and their post-synthetic modifications
… the sulphur group as a versatile position for post-synthetic modification. The advantage of application of post-synthetic modification lies in its convenience. Synthesis of oligomers with normal sequences has become routine work in most laboratories. However, design and synthesis of a proper …
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Functionalization of metal-organic frameworks with early transition metals : from fundamental studies to catalytic applications
… towards further framework elaboration via post-synthetic modification (PSM), a method to alter the chemical structure of preformed MOFs. The secondary building units (SBUs) of MOFs, which are commonly small inorganic clusters, have been particularly interesting targets for this synthetic …
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Investigating the parameters of metal-organic framework crystal growth control for reverse osmosis membrane nanofillers and direct air capture of CO2
… isotropy of these materials. MOFs also exhibit post-synthetic modification capabilities, which, along with their tunable synthetic nature, make them promising candidates for composite materials such as functionalized nanofillers for reverse osmosis (RO) desalination. The work described herein …
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Toward the rational design of multifunctional nanomaterials: synthesis and characterization of functionalized metal-organic frameworks
… incorporate functional groups into a MOF is the modification of the organic precursor with specific substituents before synthesizing the MOF itself; we call this approach pre-functionalization method. Functionalization of organic precursors is the initial and necessary step to obtaining …
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Synthetic and Post-Synthetic Methods towards Fine Tuning the Chemical and Physical Properties of Metal-Organic Frameworks
This thesis explores synthetic and post-synthetic strategies for tailoring the chemical and physical properties of metal-organic frameworks (MOFs), with a particular emphasis on modulating redox activity, framework composition, and ionic conductivity. The first part of the work focuses on …
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Tailoring Metal–Organic Frameworks for Water Harvesting
… 7, the author explores an alternative method for post-synthetic modification, whereby chlorine radical abstraction is utilized to reduce a framework, which may be useful for the synthesis of new sorbents.
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Modified oligonucleotides for the functionalisation of nanoscale materials
… nanoparticle substrates. As such, routes to the modification of oligonucleotides by thioctic acid are reported herein. Although the phosphoramidite method was found to be unsuccessful, the H-phosphonate method has been shown to be effective for direct modification. In addition, a key intermediate …
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Site-Specific Labelling of Nucleic Acids by Catalyst-Free 1,3-Dipolar Cycloadditions
… (SPAAC) were explored. The possiblitity for ‘pre-synthetic’ functionalisation was demonstrated using non-nucleosidic phorphoramidite building blocks generated by NOAC. Three isoxazole phosphoramidites were prepared. Following in situ generation of the nitrile oxides from 1,2-, 1,3- or …
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Development of N-heterocyclic carbene ligands for nanomaterials in aqueous media and expanding the interface of metal-organic framework (MOF) and polymer chemistry via polyMOFs
… available for (1) metallic nanomaterial surface modification and (2) metal-ligand driven supramolecular assembly. (1) Surface ligands are typically used for surface passivation, imparting new properties such as solubility, or introducing a functional handle for further modification. The different …
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Synthesis and Characterization of Red and Near-Infrared BODIPY-based fluorophores for various Biological Applications
… introduction to the fundamental concepts, synthetic routes, post-synthetic modification strategies and various biological applications of BODIPY dyes, that are further elaborated upon in the following Chapters. Chapter 2 describes the synthesis, characterization, computational modeling and …
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Post-Synthetic Chemical and Morphological Modifications of Polymer Membranes for Gas Separations
… Free volume manipulation (FVM) is an innovative post-synthetic modification approach designed to address the permeability–selectivity tradeoff of polymer membranes. This method involves protection/deprotection chemistries of labile functional groups, such as a tertbutoxycarbonyl group (tBOC), to …
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Mechanically Interlocked Linkers for Dynamic Metal-Organic Frameworks
… UWCM-2. Subsequent removal of the macrocycles by post-synthetic modification utilizing Grubbs-Hoveyda II catalyst generates a potentially high porosity MOF not accessible by any other synthetic protocol, other than Reversible Mechanical Protection (RMP).
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Synthesis, Characterization, and Evaluation of Novel BODIPY Dyes With Theranostic Applications
… concepts of the BODIPY fluorophores. The synthetic routes, post-synthetic modification strategies, and several biological applications of BODIPYs are introduced and will be elaborated upon in subsequent chapters. Chapter 2 describes the synthesis, characterization, computational modeling …
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Design and synthesis of components for optically active metal-organic frameworks (MOFs) and synthetic routes to diverse deuterium labelled α-diazoacetates, α-diazoacetamides, α-diazoketones, and the antibiotic azaserine
… Secondary functional groups can undergo post-synthetic modification resulting in the introduction of a catalytically active site. Within this research project an effective method for purification of commercially available acetylene was developed and a reliable protocol for a [2+2+2] …
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Hemoglobin Alc: Structure, Biosynthesis and Clinical Significance In Diabetes Mellitus
… onset of diabetes. Hemoglobin A1C is made as a post-synthetic modification of hemoglobin A at a constant slow rate throughout the life of the red cell. In diabetic humans, hemoglobin A1C concentration correlates with the severity of disease. Changes in the quality of diabetic control are …
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The Effect of Framework Structure and Chemical Functionality on Melting in Zeolitic Imidazolate Frameworks
… further altering the chemistry in a ZIF glass by post-synthetic modification (PSM). A novel amine-functionalised ZIF glass was prepared that would be an ideal candidate for PSM. As a proof of concept, this amine-functionalised ZIF glass was reacted with octyl isocyanate, resulting in a …
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Understanding the Impact of High Aspect Ratio Nanoparticles on Desalination Membrane Performance
… pores, the sizes of which may be tuned with post-synthetic modification. Both CNCs and MOF nanorods were incorporated into TFN membranes via interfacial polymerization, and the resulting membranes were characterized using a variety of techniques to establish their performances, but also to …
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Synthesis and Characterization of pure-phase Zr-MOFs Based on meso-Tetra(4-carboxyphenyl)porphine
… of nanoscopic metal-organic polyhedrals (MOPs), post-synthetic modification, etc. These strategies provide an opportunity to engineer porphyrin-based MOFs that can target a specific application or serve as multi-functional assemblies. Porphyrin-based MOFs provide a tunable platform to perform a …
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