Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"positive-sense single-stranded RNA viruses"”.
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Analysis of the interaction between the 2C protein of parechoviruses and lipid droplets
Picornaviruses are non-enveloped, positive sense single-stranded RNA viruses which cause many diseases ranging from slight illness to fatal meningitis and encephalitis. There are no vaccines against most picornaviruses so drugs need to be developed. Human parechoviruses (HPeVs) are being …
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Generation and Characterization of Flavivirus Receptor-Binding Domain Mutants and Chimeras
Flaviviruses are positive-sense, single-stranded RNA viruses responsible for millions of infections annually. Primarily transmitted by ticks and mosquitoes, their associated diseases range from mild febrile infections to encephalitis and hemorrhagic fever. The molecular basis of the differences in …
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Coronavirus Replicase Proteins: Multifunctional Mediators of Replication and Innate Immunity Evasion
<p>Coronaviruses are positive-sense, single-stranded RNA viruses. The majority of the RNA encodes non-structural proteins (nsps) that are translated as a large polyprotein, which is cleaved by the papain-like (PLP) and picornavirus 3C-like (3CLpro) proteases. The nsps modify host membranes to …
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Evaluation of arthropod-borne virus recombination potential and phenotype: In vitro and in vivo analysis of flavivirus and alphavirus model systems
Recombination is a mechanism whereby positive sense single stranded RNA viruses exchange segments of genetic information. Recent phylogenetic analyses of naturally occurring recombinant flaviviruses have raised concerns regarding the potential for the emergence of virulent recombinants either …
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Assessing and understanding the generation and function of RNA decay intermediates in non-insect borne flaviviruses
… correctly to stimuli or to maintain homeostasis. RNA viruses must act to preferentially drive production of their own messenger RNAs (mRNAs) and proteins in order to successfully replicate and ensure continued infection. Due to the necessity for RNA viruses to remain in the cytoplasm, regulatory …
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Counteracting Neuroinvasive RNA Viruses: Antiviral and Immune Modulation Strategies Against SARS-CoV-2 and VEEV
… areas of research that warrant further study. RNA viruses have since been at the forefront for pandemic and prevention preparedness due to their increased potential to cause future outbreaks. SARS-CoV-2 and Venezuelan equine encephalitis virus (VEEV) are both zoonotic positive-sense …