Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"positive strand RNA viruses"”.
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Prenylation in cell-intrinsic innate immunity to positive-strand RNA viruses
… critical facet of the innate immune response to viruses. Since virtually every subcellular compartment can be utilized by viruses for replication, antiviral factors must also be positioned in these compartments to effectively interact with various viral threats. In this thesis, we explored the …
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Characterization of an Amphipathic Alpha-Helix in the Membrane Targeting and Viral Genome Replication of Brome Mosaic Virus
Positive-strand RNA viruses associate with specific organelle membranes of host cells to establish viral replication complexes. The replication protein 1a of brome mosaic virus associates strongly with the nuclear endoplasmic reticulum (ER) membranes, invaginates membranes into the lumen, and …
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Cornichon Proteins: Unexpected Roles in Plant Pathogen Infection, ER Morphology Maintenance and Pollen Development
… have very limited understanding of plant CNIHs. Positive-strand RNA viruses assemble their viral replication complexes (VRCs) at specific host organelle membranes. With a better understanding of host factors involved in targeting viral replication proteins to the preferred organelles, we expect …
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Understanding the Host Cellular Response to Astrovirus Infection
<p>Astrovirus is a non-enveloped positive-sense single-stranded RNA virus that infects the small intestine and causes gastrointestinal disease in most hosts. However, in immunocompromised patients, astrovirus can infect the brain, causing encephalitis and death. Here, we characterize astrovirus …
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A computational approach for identification and development of novel inhibitors targeting viral polymerases
Positive strand RNA viruses, which include hepatitis C virus (HCV), human immunodeficiency virus (HIV, and Bovine Viral Diarrhea Virus (BVDV), are known to create havoc for humans and animal health alike. Although vaccines have helped to control several of the most important viral pathogens, there …
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FUNCTIONAL CHARACTERIZATION OF PAPAIN-LIKE PROTEASE p48 REQUIRED FOR REPLICATION OF HYPOVIRUS CHV-1 RESPONSIBLE FOR VIRULENCE-ATTENTUATION OF THE CHESTNUT BLIGHT FUNGUS
… has been shown to be dispensable for hypovirus RNA replication, whereas protease p48 is essential for hypovirus RNA replication. The p48 protein can also act <italic> in trans </italic> to complement a mutant CHV-1/EP713, p48 deficient virus (δp48). The δp48 mutant virus retained …