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Showing 1 to 20 of 150 for “"positive selection"”.
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Machine learning methods for detecting positive selection
… adaptation, often manifesting as signatures of positive selection acting on protein-coding genes. Detecting such signals sheds light on evolutionary processes such as functional divergence, coevolutionary dynamics and phenotypic innovation. However, whilst the study of natural selection has been …
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Sperm sequencing reveals extensive positive selection in the human germline
… from sperm. Our findings reveal extensive positive selection in the male germline, implicating new genes, pathways, and mutational mechanisms in this process. Annotation of positively selected genes identified in our study found that most are known to cause pathogenic disorders when …
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Detection of positive selection resulting from Nevirapine treatment in longitudinal HIV-1 reverse transcriptase sequences
… (MTCT). In some cases, babies get infected and positive selection for viruses resistant to nevirapine may be inferred. Positive selection can be inferred from sequence data, when the rate of nonsynonymous substitutions is significantly greater than the rate of synonymous substitutions. …
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Use of a direct, positive selection strategy to generate improved prodrug-activating enzymes for cancer gene therapy
… x 106 possible nucleotide combinations. A direct positive selection strategy, which utilises bacteriophage lambda and the SOS response, was used to select NTR variants with increase sensitivity for CB1954 from each library. NTR mutants with greatest sensitivity were analysed by bacterial IC50 …
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Extracellular Signal-Regulated Kinase 7, A Fast Evolving Map Kinase Under Positive Selection, Is Associated With Multiple Levels Of Honeybee Behavioral Plasticity
Submitted by Jason Ebaugh (ebaugh@illinois.edu) on 2009-07-04T21:26:59Z No. of bitstreams: 1 EbaughJasonDissertation.pdf: 9370507 bytes, checksum: 6fc1987ff7690d3a540912672da149c0 (MD5)
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Evolutionary analysis of mammalian genomes and associations to human disease
… evolution and to detect signals of natural selection. Genes that have undergone positive selection during evolution are indicative of functional adaptations that drive species differences. Genes that underwent positive selection during the evolution of humans and four mammals used to model …
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Functional Characterization and Evolutionary Analysis of Lepidopteran Cytochrome P450 Genes Involved in Plant -Insect Interaction
… the mechanisms underlying the reciprocal selection between plants and their herbivores and provide useful information on the changing function of these enzymes. Here we demonstrate, using evolutionary, functional and structural methodologies to investigate the significance of positive …
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Are bats evolving more potent antiviral immune systems? Investigating the evolution and antiviral capacity of SERINC3 in Rhinolophus bats
… SARS, Ebola virus and Nipah virus. Genetic positive selection analysis conducted in a recent study has revealed a pattern of antiviral immune genes under positive selection across various bat species. One of these genes is the antiviral restriction factor SERINC3. The SERINC protein family …
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Quantitative Analyses of Normal and Precancerous Somatic Evolution in Human Tissues
… precancerous tissues. Genetic alterations under positive selection in ostensibly healthy tissues have implica tions for cancer risk. However, total levels of positive selection across the genome remain unknown. How much positive selection elsewhere in the genome is missed by gene-focused …
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The Molecular Evolution of the Serotonin System in Macaques (MACACA): a Detailed Survey of Four Serotonin-Related Genes
… theory, discern which evolutionary force – positive selection, balancing selection, purifying selection, or random genetic drift – is most likely to have acted on these genes. Three out of the four genes (HTR1B, TPH2, and SLC6A4), show a low level of overall genetic variation within the …
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Functional Sorting of Evolutionary Effects in Protein Domains
… genetics is whether a gene of interest is under positive selection, negative selection or neutral evolution. Although there are numerous existed methods and statistical tests to detect the action of positive selection, almost all of them heavily rely on the availability of enough within-species …
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Selfish Mutations: the Genetic Basis of the Paternal Age Effect
… used to model the probabilities of mutation and positive selection with cell divisions. This model provided average numbers of mutant sperm produced with increasing paternal age. The proportions of mutant to wildtype cells with increasing paternal age was used to generate a simulated population …
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Gene cloning studies in two nocardioform bacteria
Nocardioforms are Gram-positive, aerobic actinomycetes and are a metabolically diverse group which produce antibiotics, useful enzymes, are important in the biotransformation of organic compounds and the decomposition of organic wastes and are important medically. A gene cloning vector designated …
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A SURVEY OF THE COMMON LOON (Gavia immer) GENOME REVEALS PATTERNS OF NATURAL SELECTION
… not been characterized—by finding signatures of positive selection as evidence for genomic adaptation.</p> <p>I used Illumina short read sequencing data from a single female common loon to produce a fragmented assembly of the common loon (<em>Gavia immer</em>) genome. The resulting assembly had a …
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Genetic Diversity And Evolution Of Disease Response Genes In Sorghum Bicolor L. Moench And Other Cereals
… disease resistance genes diverge under recurrent positive selection as a result of a molecular arms-race between hosts and pathogens. However, these studies have been conducted mainly in animals and few plant genes have been shown to evolve adaptively. The study of plant molecular adaptation for …
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Immune-driven positive and balancing selection in human populations
This thesis examines the evidence for positive and balancing selection on immune genes in 388 individuals grouped into thirteen geographically diverse populations. The data are high coverage whole genome sequences, many from populations that have been sparsely represented in global genetic …
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Genetic and biochemical studies of Vibrio alginolyticus glutamine synthetase
… in Escherichia coli HB101 employing the positive selection vector pEcoR251. A glutamine synthetase (GS) gene, glnA was identified by complementation of the glnA deletion in E. coli ET8051 glnA, glnL, glnG deletion strain. The glnA region of V. alginolyticus was cloned on a 5.7 kb insert …
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Naujų Mu transpozonų konstravimas ir jų panaudojimas baltymų struktūros tyrimuose /
… were identified. Based on this information five positive selection cloning vectors of new generation were constructed: pJET1-3A, pJET1-1MCS, pJET1-2MCS, pJET1-3MCS, pJET1-4MCS. In addition, plasmid pJET1-3A was tested for its cloning properties and found to work very well. It was also shown that …
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Haplotype-Based Approaches For The Study Of Human Evolution
… the question, how often are signatures of recent positive selection shared across populations, vs. unique to a single population? After performing an initial scan for signatures of positive selection in 20 human populations, I used haplotype clustering to identify regions of the genome where the …
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B Cell Receptor Signalng in Germinal Centers
… diversification, and antibody affinity selection. This process is limited and directed by T follicular helper cells that provide helper signals to B cells that endocytose, process, and present cognate antigens in proportion to receptor affinity. GCs play a crucial role in immunity by …
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