Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"porous scaffolds"”.
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Design and Application of Chitosan/biphasic Calcium Phosphate Porous Scaffolds for Bone Tissue Engineering
Cell loaded tissue engineered constructs were produced in vitro at clinically relevant sizes and implanted with and without bFGF into a porcine mandibular defect model. Tissue engineered constructs facilitated the healing of mandibular defects only if combined with delivery of bFGF via gelatin …
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Effects of Therapeutic Radiation on Polymeric Scaffolds
… the effects of therapeutic radiation on three porous scaffolds: polycaprolactone (PCL), polyurethane (PU) and gelatin. Porous scaffolds were fabricated using solvent casting and/or salt leaching techniques. Scaffolds were placed in phosphate buffered saline (PBS) and exposed to a typical cancer …
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Modelling the movement of superparamagnetic beads engulfed in endothelial cells
Colonization of porous scaffolds with cells is of increasing importance for various tissue engineering applications. Controlled placement of human umbilical vein endothelial cells (HUVECs) within a micro-porous, poly-caprolactone scaffold is facilitated with superparamagnetic beads introduced to …
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Optimization of structural and mechanical properties of electro-spun biodegradable scaffolds for vascular vissue regeneration
… techniques have been introduced for producing porous scaffolds including electro-spinning. This study involved the development and optimisation of electro-spun biodegradable scaffolds for vascular tissue regeneration by tailoring parameters of the electro-spinning process and investigating the …
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Bioactive Cellulose Nanocrystal Reinforced 3D Printable Poly(epsilon-caprolactone) Nanocomposite for Bone Tissue Engineering
Polymeric bone scaffolds are a promising tissue engineering approach for the repair of critical-size bone defects. Porous three-dimensional (3D) scaffolds play an essential role as templates to guide new tissue formation. However, there are critical challenges arising from the poor mechanical …
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Creation of Ovalbumin Based Scaffolds for Bone Tissue Regeneration
… that promote cellular responses. Micro-porous scaffolds are a promising construct for bone tissue regeneration; therefore OA crosslinked with three different concentrations (10%, 15% and 20%) of glutaraldehyde (GA) was used in this research. After fabrication, a porous morphology was …
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Microstructure-induced capillary force effects on penetration and release in hydroxyapatite bone scaffolds
Ceramic bone scaffolds with both microporosity (<50µm) and macroporosity (>100µm) are known to enhance bone formation. Including microporosity in a scaffold increases bone volume and distribution. The integration of the bone with the scaffold is also improved as both cells and mineralized bone have …
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Development and assessment of calcium phosphate bone substitutes for orthopaedic applications
… comparable to healthy bone is a challenge. Porous scaffolds based on calcium phosphate (CaP) ceramics such as hydroxyapatite (HA) and (3-tricalcium phosphate (P-TCP) have potential in the treatment of injured and diseased bone.<br/><br/>Degradation of CaP’s in vivo occurs as a result of …
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Preconditioning Methods in Cartilage Tissue Engineering: Influences of Silk Material Properties and Hypoxia on Chondrogenesis
… properties compatible to native tissue, scaffolds should provide structural support, maintain cell phenotype and subsequently promote tissue development. The focus of this dissertation is on utilizing the physiological conditions found in joints to regulate biological behavior of cells. …
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Development of polyHIPE scaffolds for improved bone regeneration
… system based on emulsion-templating to create porous scaffolds for bone grafting to address these limitations. These polymerized high internal phase emulsions (polyHIPEs) are biodegradable, maintain strong mechanical properties, and can be applied as injectable bone grafts or 3D printed for …
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Freeze-Casting For Facile Synthesis Of Novel Porous Materials
Freeze-casting is a method of synthesizing porous materials from mixtures comprised of a dispersed phase (colloidal and/or solutal) and a liquid dispersant, typically water. Cooling the mixture to temperatures below the freezing point of water causes nucleation and growth of ice crystals along the …
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Rapid 3-D laser microprinting of bioscaffolds and patterning of proteins
… majority of tissue engineering strategies use porous scaffolds containing chemical cues for culturing cells. However, these methods are unable to truly recapitulate the complexity of the in-vivo environment, limiting the effective regeneration. Several techniques have been developed to create …
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Digital Fibers: Materials, Processing, and Information
… technique is also capable of printing custom porous scaffolds from engineered porous fibers, enabling a means for accelerated nerve regeneration for patients with nerve injuries. Finally, I describe the fabrication of fibers with digital capabilities, including memory storage and …
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Ovalbumin-Based Scaffolds Reinforced with Cellulose Nanocrystals for Bone Tissue Engineering
… a major area of study is developing bone scaffolds that will provide support for osteoblasts. Despite many advances in recent years there is still a significant need for new bio-based 3-D porous scaffolds that possess sufficient initial mechanical properties to prevent immediate failure …
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Combinatorial Polymer Synthesis and High-Throughput Screening Technology to Identify Optimal Approaches for Mineralized Tissue Engineering
… The identified macromer, A6, was processed into porous scaffolds using a particulate leaching technique. When implanted, A6 scaffolds had minimal inflammation and tissue readily invaded the porous structure, but no bone formation was observed with A6 scaffolds alone. However, in intramuscular and …
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Design of Engineered Biomaterial Architectures Through Natural Silk Proteins
… work demonstrated the production of a range of porous scaffolds capable providing meaningful response to environmental stimuli, with application in tissue engineering scaffolds and biosensing technologies. Finally, to expand the capabilities of silk proteins beyond process-driven parameters to …
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Ultra-rapid 2-D and 3-D laser microprinting of proteins
… or replace damaged tissue, often relying on porous scaffolds as an artificial extracellular matrix to support cell development. However, these grafts are unable to recapitulate the complexity of the in vivo environment, limiting our ability to regenerate functional tissue. Biomedical …
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Novel processing of porous bioceramic structures
… treatment option for bone regeneration. Scaffolds are used in tissue engineering to direct tissue development and open pore scaffolds with a pore size range of 100 – 400 μm and porosity >90%, are preferred. Bioceramics have been used in numerous orthopaedic applications since the 1960s. …
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Materials and Nanostructured Coatings for Soft Tissue Regeneration
… with the use of polymeric substrates (myocardial scaffolds or heart patches) that can reduce cell loss and potentially prevent remodeling and fibrotic processes. In in vivo MTE strategies, scaffolds should be capable to recruit cardiac progenitor and differentiated cells which are present in the …
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