Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 51 for “"porcine model"”.
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Porcine model of xenobiotic metabolism
… few decades. The pig is an appropriate animal model for the investigation of xenobiotic disposition, as the transporters and CYP enzymes are very similar to those in humans. The characterization of porcine drug metabolism genes and the genes involved in regulating drug metabolism can provide …
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Examination of ex-vivo lung perfusion in porcine model
… donor after circulatory death (DCD) large animal model, by using porcine lungs initially from local abattoirs followed by change to a more suitable lungs source. As part of the experimental validation, I have shown that there is an initial bacterial load within the perfusate prior starting EVLP, …
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Computational simulation of skull fracture patterns in pediatric subjects using a porcine model
… cases.</p> <p>Finite element (FE) computational modeling techniques can be used to simulate failure of materials, including biological materials such as bone. However the efficacy of these methods has not been thoroughly tested against a well-defined experimental dataset, particularly for the …
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Myocardial ischemia-reperfusion and cardioprotection. A study with microdialysis in a porcine model.
… local coronary artery flow in an open chest pig model. Myocardial interstitial metabolites demonstrated characteristic, significant, and reproducible changes as decreased glucose, increased glycerol, and increased lactate/pyruvate ratio during ischemia, normalizing after reperfusion. Of special …
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Methodology for quantitative assessment of perfusion in porcine model of peripheral arterial disease
Peripheral artery disease (PAD) is the degradation of perfusion in the lower muscles caused by the narrowing of upstream arteries. Currently, the diagnosis and prognosis of the disease rely almost entirely on hemodynamic metrics of major vessels affecting the periphery. Quantitative assessment of …
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A porcine model for polymicrobial respiratory infections with swine influenza virus and Staphylococcus aureus
… bacteria threatens human health. A large-animal model effective for study of polymicrobial infection comparable to humans must therefore be developed. IAV has been studied extensively in small animals, including mice, rats and ferrets. However, these species frequently require IAV adaptation, …
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The safety and efficacy of novel dual function coronary stent in porcine model of myocardial infarction
… a significant decline in EF secondary to LV remodelling at 6 weeks (P<0.05). Conclusions: This study demonstrated the feasibility to develop dual function coronary stent carrying anti-restenotic and cardioprotective drugs. Despite favourable in vitro results, the stent failed to reduce ISR and …
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The effects of acidified pepsin on porcine vocal fold tissue: Developing a porcine model of laryngopharyngeal reflux disease
… hypotheses relating to laryngeal disease because porcine vocal folds are most similar to human vocal folds from a structural, biochemical, neuromuscular, and cellular perspective. By utilizing the pig as a model of laryngeal disease, research involving basic, translational, and clinical questions …
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Development of a porcine model for the testing of the rapidvent emergency ventilator for the treatment of Covid-19
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-09-01 without embargo terms
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Mitigation of intrarenal pressure in retrograde intrarenal surgery with a novel isoprenaline eluting guidewire
… To prepare for our investigation on the porcine model, we required a simulation model to precisely outline the procedural procedures. Commercially available models are expensive and not readily accessible. Chapter 2 delineates the design and fabrication of the Frere Intrarenal Surgery …
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A study of defibrillator waveforms, vectors, and therapies Kevin Anthony Michael.
The defibrillation studies were performed in a porcine model given its resemblance to the human heart and its resilience to repeated ventricular fibrillation inductions (VF) and defibrillations. A novel sequential preshock waveform was assessed in a prototype serial capacitance device. Single and …
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A Sr-90 Irradiation Device for the Study of Cutaneous Radiation Injury from a Radiological Incident
… of a larger project to study Grade III CRI in a porcine model and examine the efficacy of KeraStat<super>TM</super>, a topical product with the potential to heal CRI.
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The Use of Synthetic Platelets to Augment Hemostasis
… half bleeding times in a femoral artery injury model in rats. The aims of the present study were to: 1) Determine their efficacy in a lethal hemorrhagic liver injury model, 2) determine the impact of targeting ligand concentration on hemostasis, and 3) test them in a clinically relevant porcine …
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The Immune Modulatory Effects of Tylvalosin in Porcine Neutrophils and Macrophages in vitro
… pro-resolving of tylvalosin benefits in a porcine model by elucidating its effects, in isolated neutrophils and monocyte-derived macrophages from piglets. Our findings indicate that TYL increases porcine neutrophil and macrophage apoptosis in a dose-dependent and time-dependent manners, …
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Deciphering the heterogeneity and spatial architecture of tumors
… to quantify intra-tumor heterogeneity in a porcine model, showing its potential impact on translational clinical studies. Finally, we attempt to detect negative selection in the cancer exome by performing a depletion analysis on neoantigens.
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A conformable ultrasound patch for cavitation enhanced transdermal cosmeceutical delivery
… contact (20 cm²). Multiphysics simulation models, acoustic spectrum analysis and high-speed videography are used to characterize transducer deflection, acoustic pressure fields and resulting cavitation bubble dynamics in the coupling medium. The final system demonstrates a 26.2-fold …
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Hypothermia as an adjunctive therapy in Acute Myocardial Infarction and Cardiogenic Shock
… For paper I-III, an experimental closed chest porcine model was used. Ischemia was induced by occlusion of the LAD using a PCI-balloon. Different hypothermia protocols using cold saline, endovascular cooling in combination or alone were tested. Infarct size and microvascular obstruction were …
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A study of the effects of sucralfate in the bile duct litigated pig peptic ulcer model with particular reference to the effects on the physico-chemical properties of gastric mucus and including comparisons with famotidine and misoprostol
… claimed effects on mucus, using an experimental porcine model of peptic ulceration, the bile duct ligated pig. In addition, the effects of Sucralfate were compared with those of Famotidine and Misoprostol, and changes in mucous prostaglandins, gastric juice pepsin and gastric flora were sought. …
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Soft Robotic Platforms for the Simulation of Cardiovascular Disease and Device Development
… hinges on the utilization of high-fidelity models of human disease. The closer these models emulate the intricacy of pathophysiological phenomena driving diseases and their effects, the greater their potential impact on clinical medicine. This thesis delves into the exploration of soft …
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