Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"population sequencing"”.
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Population Sequencing for Studying Natural and Artifcial Variation in C. elegans
<p>The advent of high coverage and low cost sequencing technologies has allowed for</p><p>newer and more powerful approaches in molecular and population genetics. Transposon</p><p>sequencing, where genome-saturated mutant populations allele frequencies are</p><p>measured before and after selection, …
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Studying Mechanisms of Ionizing Radiation Resistance in Bacteria: Evidence for Multiple Pathways
Our lab created ionizing radiation (IR) resistant populations of E. coli MG1655 through twenty cycles of exposure to IR and outgrowth. To identify the genetic alterations responsible for increased IR tolerance, a total of seven isolates from the evolved final population were re-sequenced. However, …
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Haplotype-Based Approaches For The Study Of Human Evolution
… genetic processes of recent evolution in human populations. Tying these two projects together is a reliance on haplotype-based methods, which leverage patterns of linkage across genetic variants, to better understand the evolutionary forces at play across the genome. The first chapter addresses …
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Statistical foundations for precision medicine
… concepts. HCM has proven tractable to genomic sequencing, which guides risk stratification for family members and tailors therapy for some patients. However, these benefits carry risks. I show how genomic misclassifications can disproportionately affect African Americans, amplifying healthcare …
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An investigation Into the genetic variation of hepatitis C virus in patients coinfected with HIV
… The diversity of strains found within this population agreed well with previous studies. As the yield of HCV infections was low in Ghana, further studies were completed with the UK and European cohort. A deep sequencing approach was utilised to two effects. The first focussed on a specific …
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Caratterizzazione strutturale e funzionale dei sistemi emoglobinici di due specie di pesci (Mugil cephalus e Ophisurus serpens) e di due varianti emoglobiniche umane (HbRoma e HbF-SS-Monserrato)
… survey at birth in North Sardinian population. Sequencing of the γ globin genes revealed the TGT CGT transition at codon 93 in one of the two Gγ genes which causes the Arg for Cys amino acid replacement at position 93. The substitution was confirmed by mass spectrometric analysis …