Global ETD Search
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Showing 1 to 14 of 14 for “"population pharmacokinetics"”.
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Population pharmacokinetics and pharmacokinetic-pharmacodyamic modeling of antitubercular drugs
The pharmacokinetics of rifampicin, isoniazid, pyrazinamide and ethambutol in 78 patients with tuberculosis were described using non-linear mixed effects modeling. Pharmacodynamic data was comprised of weekly sputum liquid culture (using mycobacterial growth indicator tubes) time to detection …
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Population pharmacokinetics: model-free approach and nonlinear mixed-effects modelling
… of modern statistical methods to study pharmacokinetics of drugs. Specifically, it deals with applications and development of repeated measures analysis, so called 'population approach' methods, in the field of pharmacokinetics. hi the first part of the thesis, a new, model-free approach …
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Population Pharmacokinetics of Therapeutic Monoclonal Antibodies: Examples and Estimation Method Performance Differences
… clinical drug development of therapeutic mAbs is population PK, which attempts to quantify the typical disposition characteristics and sources of PK variability (such as between-subject, within-subject, and inter-occasion variability) within study populations. Population PK also attempts to …
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The determination and validation of population pharmacokinetic parameters of phenytoin in adult epileptic patients in the Western Cape using nonlinear mixed-effects modelling
The pharmacokinetics of phenytoin is complicated by the nonlinearity of the dose-concentration relationship which is a consequence of capacity-limited metabolism. Individualized therapy with phenytoin is therefore optimally required. As no data are available on the population pharmacokinetics of …
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Pharmacometric modelling to inform and improve TB and HIV treatment: Focus on drug-drug interactions and neglected populations
… improvements in treatment because neglected populations are often excluded from clinical trials, including pregnant and breastfeeding women, children, adolescents, those with co-morbidities requiring additional drug treatments, and those with drug-resistant strains. This leaves many …
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Pharmacokinetics, pharmacogenetics and optimisation of treatment with non-nucleoside reverse transcriptase inhibitors in HIV-infected African children
… HIV in children. Sources of variability in their pharmacokinetics and its association with virological outcome and adverse events in African children are poorly characterised, thereby limiting treatment optimisation. To fill this gap we studied population pharmacokinetics (PK) of efavirenz and …
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Optimization of 1st-line antituberculosis dosing regimens using a population pharmacokinetic approach: food effects, drug combinations and pharmacological effects
… antituberculosis dosing regimens using a population pharmacokinetic approach, quantify food effects, drug combinations and pharmacological effects. The population pharmacokinetics of rifampicin, isoniazid and pyrazinamide in 76 children with tuberculosis were described using a population …
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Clinical pharmacokinetics of low dose paclitaxel in Asian patients with nasopharyngeal carcinoma
The pharmacokinetics (PK) of low-dose paclitaxel in Asian patients with WHO Stage III nasopharyngeal carcinoma treated with a chemo-radiation regimen were determined and correlated with subjecta??s demographics, clinical parameters, outcome with the intent of optimizing therapeutic benefit to risk …
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An Investigation into the Use of Dried Blood Spot Analysis in Pharmacokinetic Studies
… detection efficiency. Intravenous dexamethasone pharmacokinetics was determined in 5 preterm neonates receiving treatment for chronic lung disease. Individual pharmacokinetic analyses were performed using a one compartment model to estimate primary pharmacokinetic parameters, clearance (mean, …
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Pharmacokinetic-Pharmacogenetic-and-Pharmacodynamic Adherence Relationships in Cohort South African HIV Infected Children on Lopinavir-and Nevirapine-Based Regimens
… HIV treatment success. Lopinavir and nevirapine pharmacokinetics demonstrate considerable inter-individual variability, which may affect treatment outcomes. At least part of this variability may be explained by host genetic factors. Associations between human genetic variants and exposure to …
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Aspects on optimisation of High Dose Methotrexate treatment in children with Acute Lymphoblastic Leukaemia
… central nervous system (CNS) relapse, to build a population pharmacokinetic model from methotrexate concentration time data and assess how pharmacokinetic parameter predict relapse risk. An increase in serum creatinine of more than 50% could identify individuals with a delayed elimination of …
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Investigations of Pharmacokinetic Challenges in Premature Infants
… 37 weeks) are considered a vulnerable patient population due to their immaturity at birth. Currently, off-label prescribing is common in younger pediatric populations, especially in premature neonates and infants, which is a primary group receiving intensive care. Unique pharmacokinetic (PK) …
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Evaluation of rationality and risks of pharmacotherapyin older patients in long-term care facilities
Záměr Hlavními cíli této disertační práce bylo zhodnotit dostupné informace týkající se farmakologických vlastností benzodiazepinů a jejich změn vlivem stárnutí organismu; zhodnotit prevalenci použití benzodiazepinů u geriatrických pacientů v léčebnách pro dlouhodobě nemocné; analyzovat vztah mezi …
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Beta-lactam antimicrobial dosing optimization in obese patients compared to non-obese patients using population pharmacokinetic/pharmacodynamic approach
… problem and has been associated with altered pharmacokinetics and pharmacodynamics of many drugs. However, little is known regarding the effect of obesity on the pharmacokinetics and pharmacodynamics of many broad-spectrum, beta-lactam antibiotics such as piperacillin/tazobactam, meropenem, …