Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"population heterogeneity"”.
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Metabolic flux analysis and population heterogeneity in mammalian cell culture
Metabolic flux and population heterogeneity analysis were used to develop relations between mammalian cell physiology and specific culture environments and to formulate strategies for increasing cell culture performance. Mitochondrial characteristics associated with respiration, membrane potential, …
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The Use of Violence in an Offense in a Sample of Convicted Rapists Within a Population Heterogeneity/State Dependence Framework
… and severe violence in a rape offense within a population heterogeneity/state dependence framework. Population heterogeneity asserts that crime or violence is caused by an underlying propensity while state dependence argues that prior crime or violence can increase or decrease the likelihood of …
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Cytometry of Reaction Rate Constant (Crrc): Optimization of the Technique and Development of a Novel Protocol to Assess Cell Population Heterogeneity Based on Aldh1a1 Activity in Vitro
… technique which aims to study cellular heterogeneity based on the activity of enzymatic reactions. In the past, CRRC was able to assess cellular heterogeneity in vitro by investigating the activity of ABC-transporter enzymes. However, CRRC showed poor robustness to highly motile cells. …
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Distributional Fingerprinting of Cell Population Phenotypes and Drug Activities
… measurements have traditionally been taken as population averages. Studies over the past decade, however, have established the biological relevance of population heterogeneity, even for cells with identical genetic background. The advancements of our understanding, albeit transformative, have …
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Clustering Analysis of Zernike Coefficients Through Quantile Regression
… implemented to determine the quantile at which population heterogeneity is the most significant. We illustrate the performance of the proposed method using both simulated and real data sets. In the ophthalmology data application, at quantile =0.65, the population are most heterogeneous and …
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Optimisation of the preservation of microbial cell banks for enhanced fermentation process performance
… effect on microbial cell physiology and population heterogeneity during resuscitation recovery immediately after thawing. Cell banks prepared with Tween 80 were fastest to recover after freezing in comparison to cell banks prepared with dimethyl sulphoxide which showed the slowest growth …
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Single cell decisions in endothelial population in the context of inflammatory angiogenesis
… patterns in the angiogenic endothelial cell population are consistent with one of these descriptions, the diverse population model (DPM). The DPM interpretation offers an alternative view from the traditional paradigm of cell population heterogeneity. This understanding is important in …
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Topics in Heterogeneous Group Testing
… classification and estimation in a heterogeneous population. The goal of classification is to identify all positives among those individuals screened using initial group testing results and the subsequent process of decoding of positive pools. Many decoding algorithms have been proposed, but most …
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Determination of cell fate selection during phage lambda Infection
… drive developmental processes, and produce population heterogeneity. The aim of this thesis is to re-evaluate lambda as a paradigm for stochastic behavior by determining whether and to what extent variation in cell fate selection results from pre-existing cell-cell differences rather than …
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Mergers and the Structure of Organizational Populations: Revisiting the Thrift Industry via Peter Blau
… hypotheses that were developed and examined for populations of organizations with respect to thrift mergers in the entire United States over a 29-year merger period. For the nominal dimensions over the entire span of 29 years, there is support for in-breeding; however, for the graduated …
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Quantification of gene expression in single cells
Studies of apparently homogeneous cell populations and single cells often give highly divergent results. Cells exhibit varying responsiveness to stimuli and gene expression and they are in many aspects stochastic and unpredictable. We have developed a method to measure gene expression …
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Comparison of immune responses induced by Bacillus calmette-Guerin when given at birth or at 6 weeks of age in Ugandan Infants
… and the Gambia, suggesting geographical and population heterogeneity may affect BCG-induced T cell response.
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Predictive Learning with Heterogeneity in Populations
… methods in real-world applications is the heterogeneity in populations of data instances, i.e., different groups (or populations) of data instances show different nature of predictive relationships. For example, different populations of human subjects may show different risks for a disease …
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Modeling transmission heterogeneity for infectious disease outbreaks
… caused by an index case in a fully susceptible population. Typical approaches to modeling transmission dynamics associated with infectious disease outbreaks frequently use Ro to produce deterministic case count projections, in effect treating the affected population as homogeneous (i.e. as if …
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Beyond Suspension: Light and Growth Dynamics in Immobilised Algal Cultures
… and morphology. The findings revealed spatial heterogeneity among cells within colonies, providing insights into the effects of contact inhibition and micro-gradients of mass transfer. The radial propagation of ring-like oscillations, characterised by variations in parent cell size and …
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Analysis and operations in complex networked systems: From urban infrastructure to epidemics
… disease propagation dynamics and control in population contact networks. Under each topic, one or several studies are performed with different focuses to reveal insights on varies aspects of the real-world networked systems, and provide decision-making frameworks to operational problems. …
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Bayesian analysis of finite mixture distributions using the allocation sampler
… used for density estimation or to model population heterogeneity. One can think of a finite mixture distribution as grouping the observations into components from which they are assumed to have arisen. In certain settings these groups have a physical interpretation. The interest in these …
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Social disorganisation theory and violent crime: A spatial-econometric analysis of Chicago and Sydney
… is used as independent variables: disadvantage, population heterogeneity, residential mobility, family disruption and urbanisation. Criminal violence forms the dependent variable. All variables are observed to exhibit spatial autocorrelation. In response, Spatial Durbin Models are selected for …
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Influenza a virus gene expression heterogeneity regulates viral superinfection potential and host innate antiviral response
… significance of this intrinsic gene expression heterogeneity at single particle level remains poorly understood. Here, I aim to investigate that whether and how this heterogeneity influences viral superinfection and host innate antiviral response. To initiate productive infection, multiple SIPs …
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Evolution of Pseudomonas aeruginosa in the Cystic Fibrosis Lung
… one order of magnitude or greater than the population median (2.5x10-8). Strains were phenotyped with respect to mucoid status, antibiotic resistances, and frequency of RifR mutants, and genotyped with respect to presence of plasmids, rep-PCR (BOXA1, ERIC) and PFGE (SpeI and DraI) …
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