Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"population admixture"”.
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Algorithms for genomics and genetics : compression-accelerated search and admixture analysis
… new computational tools for investigating population admixture, a phenomenon of importance in understanding demographic histories of human populations and facilitating association mapping of disease genes. Our recently released ALDER and MixMapper software packages provide fast, sensitive, …
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Population genetics and transmission dynamics of Plasmodium falciparum in the Kavango East and Zambezi regions of Namibia
… and Zambezi regions of Namibia The study through population genetics analysis showed that the genetic structure of P. falciparum in Namibia follows the pattern of a high transmission setting, there are high levels of genetic diversity, low genetic relatedness, random mating and population …
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Future Preventive Gene Therapy of Polygenic Diseases from a Population Genetics Perspective
… soon become possible. This research assesses the population genetic consequences of such therapies. This research commenced by quantifying the risk of polygenic late-onset diseases. Computer simulations of population age progression under the assumption that relative disease liability remains …
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Exploring new methodologies to identify disease-associated variants in African populations through the integration of patient genotype data and clinical phenotypes derived from routine health data: A case study for Type 2 Diabetes Mellitus in patients in the Western Cape Province, South Africa
… identify disease-associated variants in African populations through the integration of patient genotype data and clinical phenotypes derived from routine health data: A case study for Type 2 Diabetes Mellitus patients in the Western Cape Province, South Africa. Abstract Introduction There is poor …
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Human population history and its interplay with natural selection
… thesis, I aimed to refine our knowledge on human population history using ancient genomes, and then used a climate-informed, spatially explicit framework to explore the interplay between complex demographies and selection. I first analysed a high-coverage genome from Upper Palaeolithic Romania …