Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"popPK"”.
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Investigations of Pharmacokinetic Challenges in Premature Infants
… in the theophylline population pharmacokinetic (PopPK) study in order to get an appropriate study design with the optimized sample size. Finally, PopPK of caffeine was investigated in premature infants using clinical data. Optimized dosing regimens were developed based on the PopPK model and …
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STATIC AND DYNAMIC FORMS TO IDENTIFY DDI POTENTIAL AND SOURCES OF PHARMACOKINETIC VARIABILITY
… timepoints in a population pharmacokinetic (PopPK) model. Understanding how co-administered drugs interact is critical for determining how one can impact the efficacy and safety of another in potential drug-drug interactions (DDIs). Furthermore, it is important to establish the DDI risk of …
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Evaluation of amoxicillin, metronidazole and gentamicin dosage regimens for use in antibiotic prophylaxis in colorectal surgery
… the value of using population pharmacokinetic (PopPK)modelling to assess an antibiotic prophylaxis regimen in colorectal surgery with theaim of identifying optimal dosing regimens.PopPK models were developed for amoxicillin, metronidazole, and gentamicin usingNONMEM® in order to determine the …
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Contemporary challenges in clinical pharmacy practice - medicines optimisation and medication adherence
… was coupled with population pharmacokinetic (PopPK) modelling, which took account of patient characteristics, metformin dosage and type of formulation prescribed (immediate or sustained release). This study demonstrated that DBS sampling together with the use of a published PopPK model was …
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Integrating nonlinear mixed effects and physiologically–based modeling approaches for the analysis of repeated measurement studies
During the drug discovery & development process, several phases encompassing a number of preclinical and clinical studies have to be successfully passed to demonstrate safety and efficacy of a new drug candidate. As part of these studies, the characterization of the drug's pharmacokinetics (PK) is …