Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 50 for “"pomc"”.
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Growing Up POMC: Pro-opiomelanocortin in the Developing Brain
… to energy status by Pro-opiomelanocortin (POMC) and Neuropeptide-Y/agouti-related protein (NPY/AgRP) neurons in the ARH exert opposing influences on secondary neurons in central circuits regulating energy balance. My thesis research focused on the developmental events regulating the …
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Manipulation and characterization of proopiomelanocortin (POMC) neurons in the hypothalamic regulation of energy balance
… that hypothalamic proopiomelanocortin (POMC) neurons are a critical component in the maintenance of energy balance. POMC neurons release peptide transmitters that modulate pathways involved in food intake, energy expenditure, and reward pathways. POMC peptide release can result in the …
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Appetite Regulatory Neural Circuitry in the Prenatal Testosterone Treated and Obese Ewe
… neuropeptide Y (NPY), or proopiomelanocortin (POMC) and cocaine- and amphetamine- regulated transcript (CART). We then asked whether this circuitry is altered in ewes at increased risk of obesity following prenatal testosterone (T) treatment, or in diet-induced obese ewes. Using …
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Amino acid transmitters and the neural control of feeding and energy homeostasis
… peptide (NPY/AgRP) and proopiomelanocortin (POMC) cells (the so-called first order feeding neurons), have been extensively studied for their roles in energy homeostasis—mostly through research into the peptides they are named after. There is clear evidence that peptides play an essential role …
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Differences in the expression of opioid peptides in Dahl salt-resistant and salt-sensitive rats
… of their precursors preproopiomelanocortin (POMC) and preproenkephalin (ppENK) messenger RNAs in this animal model. Three week old inbred Dahl R and S rats were maintained on high salt diet (8% NaCI) or low salt diet (0.4%) for six weeks. POMCmRNA and ppenk mRNA were examined from tissues of …
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Epigenetic and Ubiquitin-Proteasome Mechanisms of Obesity Development
… appetite genes, including the satiety gene Pomc, in the hypothalamus of rodents fed a high fat obesogenic diet. However, it has not previously been studied whether diet-induced changes in DNA methylation of critical appetite genes in the hypothalamus contributes to the development and …
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Estrogen Regulation of the Pregnant Baboon Placental 11β-Hydroxysteroid Dehydrogenase (11β-HSD)-Catalyzed Metabolism of Cortisol and Cortisone and Its Effect on the Development of the Fetal Hypothalamic-Pituitary-Adrenal Axis
… mRNA for the ACTH precursor proopiomelanocortin (POMC). Pituitary POMC mRNA, was greater in baboon fetuses at term than at mid-gestation and increased on day 100 in estrogen-treated animals. Immunohistochemical studies confirmed that ACTH protein paralleled changes in POMC mRNA. Next, we …
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The role of notch signaling in the regulation of proliferation and cell differentiation during embryonic and postnatal pituitary development
… with persistent expression of activated Notch in POMC-expressing cells. We show that constitutive Notch expression prevents the differentiation of corticotropes and melanotropes, which also contain POMC. These cells instead maintain progenitor markers. In addition, mRNA levels of transcription …
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Effects of single nucleotide polymorphisms in leptin and pro-opiomelanocortin on peripheral eucocyte counts in beef cattle
… (SNP) in leptin (LEP) and pro-opiomelanocortin (POMC) have been associated with beef carcass quality and yield respectively. Both hormones also play a role in immune performance. Since both of these genes are pleiotrophic, it was important to determine whether selection based on these SNPs would …
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Modelling altered Glucocorticoid Sensitivity: From HPA axis to metabolic abnormalities in mice and humans
… HPA axis hypoactivity pro-opiomelanocortin null (POMC) mice. POMC-null mice are obese due to central melanocortin deficiency. In contrast to most rodent models of obesity, POMC-null mice are also glucocorticoid deficient due to ACTH deficiency. Previous data have shown that glucocorticoid …
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Neural Mechanisms of Homeostatic Need and Reward
… rapamycin altered gene expression exclusively in POMC neurons of DIO mice which also showed normalization of pSTAT3 levels after rapamycin treatment. Consistent with an effect on POMC neurons, rapamycin did not alter food intake or adiposity in mice after an ablation of POMC neurons or in MC4R …
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Hypothalamic control of energy rheostasis during metabolic challenges, pregnancy, and lactation
… increases AgRP neuron activity and decreases POMC neuron activity in the arcuate nucleus. Chemogenetic activation of POMC neurons or inhibition of AgRP neurons suppressed pregnancy-induced feeding, indicating that these changes are required for gestational hyperphagia. Spatial transcriptomic …
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Transition cows: hepatic endocannabinoid system gene expression in response to prepartal plane of nutrition and the effects of genetic merit on genes of lipid metabolism in adipose tissue
… and the hormone precursor proopiomelanocortin (POMC) in liver at -14, 7, 14, and 30 d around parturition from cows fed a control (CON; NEL = 1.34 Mcal/kg) or moderate-energy (OVER; NEL = 1.62 Mcal/kg) diet during the dry period. Expression of CNR2 and POMC was greater at 7 d in cows fed OVER due …
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Effects of exogenous and endogenous factors on appetite regulation in broiler chicks and Japanese quail
… receptor 3, and pro-opiomelanocortin (POMC), however within the ARC there was a decrease in POMC and an increase in c-Fos mRNA after FA treatment. OXM, a proglucagon-derived peptide produced in the gastrointestinal tract, administered intracerebroventricularly (ICV) or IP in Japanese …
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Effect of age and pregnancy on the murine melanocortin system in the female reproductive system
… The MCs are activated by proopiomelanocortin (POMC) derivatives: alpha-, beta-, and gamma-melanocyte stimulating hormones and adrenocorticotrophic hormone; while agouti signalling peptide (ASP) and agouti-related protein (AgRP) antagonise the peptide activity. The MCs were previously detected …
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The Identification of a Leptin Dependent Neural Pathway Regulating Adipose Tissue Innervation
… peptide (AGRP) neurons and pro-opiomelanocortin (POMC) neurons. We employed a CRISPRbased gene editing strategy to selectively delete LepR in either AGRP or POMC neurons and found that leptin signaling loss in either population leads to same level of SNS innervation reduction in adipose tissue. …
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Individual genetic variations of eight SNPs associated with risk of obesity in preschool age children from STRONG Kids Program
… pathway (i.e. BDNF, FTO, LEP, LEPR, MC4R, PCSK1, POMC, TUB) have been associated with symptoms of poor appetite control and obesity-related phenotypes. Hypothesis. Individual genetic variations related to satiety and appetite control in the BDNF, FTO, LEP, LEPR, MC4R, PCSK1, POMC, and TUB genes …
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Endocannabinoid and lipid metabolism genes network analysis in adipose and liver tissue of dairy cows during the transition period
… and the hormone precursor proopiomelanocortin (POMC). We also examined mRNA expression via qPCR of genes associated with lipolysis (LIPE, ABDH5, ATGL), fatty acid oxidation (CPT1A, CPT2, ACADVL, ACOX1), oxidative stress (SOD1, SOD2), and genes that are involved in inflammation (TLR9, TLR4, …
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Sampling Strategies for Characterization of Neuropeptides Using Mass Spectrometry and Functional Implications Into Cell -Cell Signaling
… putative peptide corresponding to m/z 1330.2 and POMC [205-222] are detected in the mutant and heterozygous pituitaries, but not in the wild type. These results indicate that Hes1 influences the processing of different prohormones having possible roles during development and opens new directions …
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