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Showing 1 to 20 of 29 for “"polyubiquitin"”.

  1. Mechanism underlying linkage-selective polyubiquitin recognition

    Kristariyanto, Yosua AdiUniversity of Dundee2017

    … When Ub itself is ubiquitylated, eight types of polyubiquitin (polyUb) chains can be formed: M1, K6, K11, K27, K29, K33, K48 and K63. Each one of these different chain types can couple modified proteins to diverse cellular signalling pathways. For example, proteins modified with K48 polyUb chains …

    dundee Repository record

  2. Regulation of DHX16-mediated Innate Immunity by Unanchored Polyubiquitin

    Hage, Adam RThe University of Texas Medical Branch at Galveston2022

    … modifications (PTMs), like unanchored (or free) polyubiquitin (poly-Ub), which properly regulate IFN-I to elicit responses as needed. Despite its known roles regulating critical IFN-I pathways, the extent to which unanchored poly-Ub is involved in innate immunity is unknown. To identify whether …

    utmb Repository record

  3. STRUCTURAL INSIGHTS INTO POLYUBIQUITIN CHAIN FORMATION MEDIATED BY NEDD4 HECT LIGASE

    TAIBI, VINCENZOUniversità degli Studi di Milano2023

    … with a single ubiquitin moiety or K63-linked polyubiquitin chains. Despite its critical role, the structural and mechanistic aspects of NEDD4-mediated polyubiquitination remain enigmatic. Our lab previously identified a ubiquitin exosite within HECT as critical determinant for enzyme …

    milano Repository record

  4. Polyubiquitin chain editing by UCH37 promotes degradation of a subset of proteasome substrates

    Dillon, Andrew Liam, author, Yao, Tingting, advisor, Cohen, Robert, committee member, Schauer, Grant, committee member, Ross, Eric, committee member, Prenni, Jessica, committee memberColorado State University. Libraries2025

    Branched polyubiquitin can serve as a priority signal for proteasomal degradation by enhancing proteasomal degradation of modified substrates relative to substrates modified with homotypic K48-linked polyubiquitin chains. UCH37, a proteasome-associated deubiquitinating enzyme (DUB), has been shown …

    colostate Repository record

  5. Structural characterization of interaction of K11 and K63 mixed-linkage polyubiquitin chains with the tUIMs of epsin1

    Kashyap, Tanuja2016

    … attachment of ubiquitin monomers within a polyubiquitin chain via a specific lysine residue. Thus the hypothesis is that linkage defines polyubiquitin conformation which in turn determines specific recognition by cellular receptors. Ubiquitylation of membrane surface receptor proteins plays …

    maryland Repository record

  6. Liquid-Liquid Phase Separations in Innate Immune DNA Sensing and NF-κB Signaling Pathways

    Du, Mingjian2023

    … NEMO activates IKK complex by binding to polyubiquitin chains. Here we show that Lys63(K63)-linked or linear(M1)-linked polyubiquitin chains binding to NEMO robustly induced the formation of liquidlike droplets in which IKK was activated both in vitro and in cells. Both NEMO ubiquitin …

    utswmed Repository record

  7. Biochemical Mechanism of Protein Kinase Activation by the Ubiquitination System

    Xia, Zong-Ping2010

    … TAK1-IKK cascade by TRAF6 and Ubc13/Uev1A in a polyubiquitinationdependent manner. Mechanistically how TAK1 is activated by the TRAF6- Ubc13/Uev1A dependent polyubiquitination system is unknown. Whether TAK1 and IKK kinases can be activated by other than TRAF6-Ubc13/Uev1A is an open question. By …

    utswmed Repository record

  8. Structural and biophysical analysis of the proteasomal deubiquitinase, UCH37

    Morrow, Marie Elizabeth

    … disassembly of polymeric ubiquitin chains, or polyubiquitin, which have been ligated onto proteins in order to target them for degradation. The 26S utilizes two associated deubiquitinating enzymes, UCH37 and USP14, and one intrinsic, Rpn11, to remove polyubiquitin chains from substrate proteins …

    purdue-thes Repository record

  9. Mechanisms of TRIM21-directed intracellular degradation

    Rhinesmith, TylerUniversity of Cambridge2023

    … binds and decorates the complex with these polyubiquitin chains. Polyubiquitin is a highly-conserved protein post- translational modification with a number of important roles, including the initiation of degradative processes and antiviral genetic programs. Polyubiquitin-coated …

    cambridge Repository record

  10. Hrd1 Partners In Endoplasmic Reticulum-Associated Degradation

    Burr, Aaron Alexander2015

    … ubiquitin-conjugase Ube2G2 make only K48-linked polyubiquitin. This type of chain is classically tied to protein degradation by the proteasome. However HRD1, in the presence of another conjugase Ube2J1, forms unconventional K11-, K29-, and K33-linked polyubiquitin chains. These in vitro findings …

    wayne-thes Repository record

  11. Age related memory loss and the role of the ubiquitin proteasome system

    Patrick, Morgan BriannaVirginia Tech2025

    … activity, and degradation-specific K48 polyubiquitin protein targeting in the hippocampus and retrosplenial cortex of male and female rats across their lifespan. In terms of targeted protein degradation in the hippocampus, altered protein degradation targets were involved in …

    vt Repository record

  12. Decoding Lysine-11 Signals in Ubiquitination

    Grice, GuinevereUniversity of Cambridge2018

    … signals, focusing on lysine-11 (K11) linked polyubiquitin chains and their role in protein degradation. I established in vitro assays to understand how K11-chains are decoded and whether these chains act as a signal for proteasome-mediated degradation. Pure homotypic K11-chains did not bind …

    cambridge Repository record

  13. Mechanism of Ubiquitin Induced Activation of RIG-I Like Receptors in Antiviral Innate Immunity

    Jiang, Xiaomo2012

    … E3 ligase, TRIM25, promotes Lysine 63-linked polyubiquitination of RIG-I, and is essential for the RIG-I antiviral pathway. However, the biochemical mechanisms by which RIG-I is activated by ubiquitin remain poorly understood. In addition, whether ubiquitination is involved in MDA5 activation …

    utswmed Repository record

  14. INSIGHTS INTO SUBSTRATE RECOGNITION BY THE ANAPHASE PROMOTING COMPLEX (APC)

    Qin, Liang

    … the anaphase promoting complex (APC). APC adds polyubiquitin chains to numerous substrates, which leads to their subsequent degradation in late mitosis and G1 phase. The selective and timely recognition and degradation of APC substrates is essential for proper cell cycle progression and …

    purdue-thes Repository record

  15. The Phase Behavior of Ubqln Proteins and Implications for Protein Quality Control

    Yang, Yiran

    … UPS and autophagy signaled by ubiquitin (Ub) or polyubiquitin (polyUb) chains. Shuttle proteins facilitate cargo transporting by interacting with both ubiquitin and degradation machineries. Previously, our lab discovered that the shuttle protein Ubiquilin-2 (UBQLN2) is recruited to stress …

    syracuse-diss Repository record

  16. Quality control of protein complex assembly

    Carrillo Roas, SaraUniversity of Cambridge2023

    … that the KCMF1-UBR4 complex builds K48-linked polyubiquitin chains and helped to define the key domains on both ubiquitin and UBR4 involved in substrate recognition. UBR4 mutants impaired in substrate recognition *in vitro* were also impaired in substrate degradation in cell-based assays. These …

    cambridge Repository record

  17. Investigation into ubiquitin signalling in response to cisplatin

    Carroll, EilisUniversity of Dundee2014

    … is an E3 ubiquitin ligase that creates linear polyubiquitin chains as part of the linear ubiquitin assembly complex (LUBAC). LUBAC is required for innate and adaptive immunity, suppressing inflammation and the control of cell death through TNF and etoposide-induced signalling. HOIP was …

    dundee Repository record

  18. Biochemical and Genetic Studies on CC2D1A, a new NF-κB Activator and a Regulator of Synaptic Functions

    Zhao, Meng2010

    … enzyme specific for Lysine-63 linked polyubiquitin chains, negatively regulates the activity of CC2D1A. These results suggest that CC2D1A activates NF-κB through the canonical IKK pathway. In an attempt to identify the physiological function of CC2D1A, I generated CC2D1A knockout mice. …

    utswmed Repository record

  19. Role of the ubiquitin-proteasome pathway in the inner ear : identification of an E3 ubiquitin ligase for Atoh1

    Cheng, Yen-FuMassachusetts Institute of Technology2014

    … of Atoh1 through a lysine 48-linked polyubiquitin chain. Mutation at a catalytic cysteine within the HECT domain of Huwe1 reduced the polyubiquitylation. We also defined a motif in the C-terminus of Atoh1 responsible for interaction with Huwe1. Inhibition of proteasomal activity, as …

    mit Repository record

  20. SORTASE AND CHEMICAL BIOLOGY AS TOOLS TO STUDY UBIQUITINATION

    Raniszewski, Nicole2024

    … of proteins of interest with user-defined polyubiquitin chains. We exemplify the broad utility of this strategy for multiple different proteins of interest, including DNA replication protein PCNA. As an additional technology, we leverage this sortase-mediated ubiquitination system in …

    penn Repository record

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