Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"polysaccharide antigens"”.
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Immunologic Memory to Polysaccharide Antigens
… antibody response against previously encountered antigens. The clonal selection theory of acquired immunity attributes immunologic memory to the formation of an expanded compartment of quiescent antigen-specific memory B cells that are capable of rapid activation upon secondary antigen encounter. …
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Molecular modeling of bacterial polysaccharide antigens to inform future vaccine development
Polysaccharide conjugate vaccines have been pivotal in reducing the prevalence and severity of bacterial infectious diseases worldwide, preventing countless deaths. The effectiveness of a vaccine can be extended if the selected vaccine strains in a multivalent vaccine cross-protect against …
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Molecular modelling of the Streptococcus pneumoniae serogroup 6 capsular polysaccharide antigens
… the structural characterization of the capsular polysaccharides of Streptococcus pneumoniae is conducted using Molecular Modelling methods. S.pneumoniae causes invasive pneumococcal disease (IPD), a leading cause of death in children under five. The serotypes in group 6 are amongst the most …
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New Carbohydrate-Based Anti-Cancer And Anti-Bacterial Vaccines
… viral and fungal cells are excellent target antigens for the design of therapeutic or preventive vaccines. However, as antigens carbohydrates have problems. First, carbohydrates usually have low immunogenicity. Second, even if immunogenic, carbohydrates typically elicit T cell-independent …
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Modelling and validation of bacterial O-antigen conformations: ring puckering in Shigella flexneri 7a and 7b O-antigens as a case study
… conformation and dynamics of Shigella flexneri O-antigens. S. flexneri is a leading cause of diarrhoeal related diseases, especially in Sub-Saharan Africa and Southeast Asia. There are over 30 S. flexneri serotypes and, with the exception of serotype 6, all share a common O-antigen backbone …
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Bacterial colonization of the nasopharynx in paediatric patients with acute respiratory viral symptoms
… using immunogenic protein-conjugated capsular polysaccharide antigens of the most common invasive paediatric pneumococcal strains. Vaccination is protective against invasive disease, but also introduces selection pressures against those vaccine strains. This will likely alter colonization …