Global ETD Search
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Showing 1 to 1 of 1 for “"polyprenyl phosphate binding"”.
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Discovery and Optimization of a Family of Naturally Encoded Antibiotic Compounds that Evade Antibiotic
… This resistance evasion is attributed to a dual polyprenyl phosphate binding mechanism. In this thesis, I present discovery and optimization efforts to expand this promising novel class of antibiotic natural products as well as to develop a singular lead clinical drug candidate that displays …