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Showing 1 to 20 of 21 for “"polymorphonuclear leukocytes"”.
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Role of oxidants in the microbicidal mechanisms of polymorphonuclear leukocytes
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Circadian Flux of Extravascular Polymorphonuclear Leukocytes in the Mouse Limbus
Purpose: In the uninjured mouse cornea, a recent study suggests extravascular PMNs are found at the limbus and their numbers rise and fall in a circadian rhythm, peaking in the evening. Additional studies in other tissues suggest metabolic syndrome resulting from the consumption of a HFD is …
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Role of polymorphonuclear leukocytes in the tumoricidal activity of Propionibacterium acnes
… or without tumor cells, induced large numbers of polymorphonuclear leukocytes (PMNs) at 12 hours. To determine the role of PMNs in the killing of tumor cells, tumor cells were incubated with supernatant obtained from the phagocytosis mixture of PHNs and P. genes. After a 2- hr. incubation, the …
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The Bactericidal Activity of Human Polymorphonuclear Leukocytes Before and After the Ingestion of Glucose
… carbohydrate affects the ability of human leukocytes to destroy bacteria. Subjects were given a dose of 100 grams of glucose. Two hours later a blood sample was drawn and incubated with Staphylococcus epidermidis for 120 minutes. There was no significant difference in the bactericidal …
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Nutritional modulation of the transcriptome in adipose, liver, and polymorphonuclear leukocytes in peripartal dairy cows
… rumen-protected methionine on liver and polymorphonuclear (PMNL) gene expression of fatty acid-sensing G-protein coupled receptors (GPCRs), and 2) evaluate the effect of overfeeding during the dry period on the PMNL transcriptome. In the first study, cows were either 1) retrospectively …
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Extraction of Leucocidin From Staphylococci and Its Practical Application in the Diagnosis of Septicemia
… or depression of the mechanism by destruction of polymorphonuclear leukocytes; destruction due to a specific exotoxin elaborated by certain bacteria. In addition an attempt has been made to utilize this process of phagocytic inhibition in a practical manner in the diagnosis of septicemia and …
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Integrin Modulating Factor 1 (IMF-1): A lipid that modulates leukocyte integrins
<p>Polymorphonuclear leukocytes (PMN) express a receptor of the integrin family termed complement receptor type 3 (CR3, also known as α<sub>M</sub>β<sub>2</sub>, Mac-1, Mo1, or CD11b/CD18) that functions in several cell-cell and cell-substratum adhesion events. The capacity of CR3 to mediate …
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Effect of Sialylation of Histophilus somni Lipooligosaccharide on Virulence and Resistance to Host Defenses
… and killing of the bacteria by bovine polymorphonuclear leukocytes (PMN). Killing of H. somni by alternative complement pathway was measured by incubation of sialylated or non-sialylated H. somni with antibody-free precolostral calf serum (PCS) followed by viable plate count. A …
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Characterization of superoxide dismutase from Actinomyces
… of the cell from the O₂⁻-dependent killing by polymorphonuclear leukocytes and also enable the organism to be transported through an oxygenated environment from one site to another. The MnSODs were purified 85-240 fold from crude extracts with 30-60% yield by two chemical fractionations and …
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Staphylococcus aureus Panton-Valentine leukocidin (PVL) alters human neutrophil viability and function
… with specificity for myeloid cells, including polymorphonuclear leukocytes (PMNs or neutrophils). It is widely assumed that PVL-mediated pore formation in the plasma membrane of PMNs leads ultimately to cytolysis. However, this hypothesis has not been tested and previous studies indicate that …
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Staphylococcus aureus Panton-Valentine leukocidin (PVL) alters human neutrophil viability and function
… with specificity for myeloid cells, including polymorphonuclear leukocytes (PMNs or neutrophils). It is widely assumed that PVL-mediated pore formation in the plasma membrane of PMNs leads ultimately to cytolysis. However, this hypothesis has not been tested and previous studies indicate that …
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Investigation of Haemophilus somnus Virulence Factors: Lipooligosaccharide Sialylation and Inhibition of Superoxide Anion Production
… mammary and alveolar macrophages as well as by polymorphonuclear leukocytes. Inhibition of O2- production was time- and dose-dependent and did not occur after incubation with Escherichia coli, H. influenzae, or Brucella abortus. Non-viable H. somnus, purified lipooligosaccharide (LOS), or …
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Μελέτη των ιστολογικών βλαβών του κερατοειδούς από και τα συστατικά της slime - GLP και LPS
… of the cornea by inflammatory cells, mainly polymorphonuclear leukocytes (PMN's) within 4-8 hours after the injection. Sixteen to 24 hours from the injection the whole thickness of the cornea was occupied by the infiltrates and multiple small abscesses were noted. (b) Erosions on the …
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The effects of some antibiotics and lipopolysaccharide on oxidative burst and phagocytosis of neutrophils
… on oxidative burst and phagocytosis by polymorphonuclear leukocytes (PMNL) using a FACS 440 flow cytometer. Blood from healthy donors was pre-incubated with log doses of bacterial LPS (0.1 ng/ml - 1000 ng/ml) or sterile pyrogen-free saline at 37 °c from 0-120 minutes. LPS increased both …
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The role of oxygen free radicals in the endotoxic shock induced myocardial dysfunction and cellular injury
… IL-1, TNF and PAF are known to activate polymorphonuclear leukocytes (PMNLs), which on activation lead to increased production of oxygen free radicals (OFRs) and hypochlorous acid (HOCl). During ET-shock, OFRs could also be produced from other sources including auto-oxidation of …
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Staphylococcus aureus virulence factors dictate host signaling pathways and immune responses
… to intracellular infection and subsequent polymorphonuclear leukocyte (PMN) responses. Intracellular S. aureus increased thrombomodulin expression by MEC and activated protein C (APC) production. APC inhibited PMN chemotaxis. Findings depicted an indirect role for VF on PMN responses, so …
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Survival Of Mycobacterium Avium Subspecies Paratuberculosis In The Pol
… host, possibly infecting other circulating blood leukocytes. In this study, the survival and fate of map strain atcc 43015 (human isolate) following phagocytosis was determined using in vitro murine macrophage cell line j774a.1 and polymorphonuclear cells (pmnc's) from five crohn's disease …
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Cellular Immune Response And Gene Expression Profiling In Crohn's Dise
… of possible map presence and the function of polymorphonuclear leukocytes (pmn) and peripheral blood mononuclear cells (pbmc) in 19 cd patients and 12 controls have been evaluated. Pmn phagocytosis of viable fitc-map was suppressed in 13/19(68%) cd patients compared to 0/12(0%) in healthy …
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