Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 44 for “"polymicrobial"”.
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Viral and Bacterial Polymicrobial Interactions with Streptococcus pneumoniae in Otitis Media
… which frequently act in combination to induce polymicrobial middle ear disease. <italic>Streptococcus pneumoniae</italic> is one of the two most commonly isolated bacterial pathogens of otitis media. This dissertation examines interactions of <italic>S. pneumoniae</italic> with nontypeable …
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In vitro Recapitulation of the Polymicrobial Communities Associated with Cystic Fibrosis Airway Infections
… and the metabolism of individual members of a polymicrobial community, compared with growth as an axenic population, is becoming increasingly apparent within the field of medical microbiology. In part, these poorly understood interactions explain why, regardless of intense research efforts, …
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The role of bacterial interspecies communication in polymicrobial infection of the cystic fibrosis lung
There is an increasing appreciation of the polymicrobial nature of bacterial infections associated with Cystic Fibrosis (CF) and of the important role for interactions in influencing bacterial virulence and response to therapy. Patients with CF are co-infected with Pseudomonas aeruginosa, …
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A porcine model for polymicrobial respiratory infections with swine influenza virus and Staphylococcus aureus
… A large-animal model effective for study of polymicrobial infection comparable to humans must therefore be developed. IAV has been studied extensively in small animals, including mice, rats and ferrets. However, these species frequently require IAV adaptation, reducing the capacity of these …
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Identification of Effectors of Synergistic Lethality in Candida albicans-Staphylococcus aureus Polymicrobial Intra-abdominal Infection
… and disease.</p> <p>Using a murine model of polymicrobial intra-abdominal infection (IAI), we have previously shown that coinfection with C. albicans and S. aureus leads to synergistic lethality whereas monomicrobial infection is nonlethal. Therefore, we aimed to identify staphylococcal …
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Loss of LasR function reshapes inter-species interactions in a polymicrobial cystic fibrosis airway model
… with a variety of other microbes: these are polymicrobial infections. We now know that the interactions between co-habiting Gram-negative, Gram-positive, and fungal species can significantly impact the outcomes of these airway infections. Factors like intra-species genetic variation and …
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Characterization of polymicrobial infections in macaques with chronic cranial implants and evaluation of alternative antimicrobial strategies
Macaques are the most commonly used non-human primate in cognitive neuroscience research due to similarities between the macaque and human brain. Cephalic recording chambers (CRCs) are often surgically implanted to obtain neuronal recordings. CRCs represent a persistent source of microbial …
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Interactions between Streptococcus pneumoniae and Moraxella catarrhalis in polymicrobial communities affect antimicrobial resistance and survival in vivo
… contain multiple species of bacteria. Within a polymicrobial biofilm, the bacteria are able to share certain resources, including metabolic byproducts, virulence factors, and signaling molecules. Prior studies in the lab have shown that beta-lactamase production and quorum sensing play important …
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Pasteurella multocida biofilm formation, and the interrelationship of P. multocida with Histophilus somni in a polymicrobial biofilm during bovine respiratory disease
… P. multocida may co-exist with H. somni in a polymicrobial biofilm. Interactions between the two species in the biofilm were characterized and quantified by fluorescence in situ hybridization (FISH), and the biofilm matrix of each species examined by fluorescently-tagged lectins (FTL), …
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HAEMOPHILUS INFLUENZAE AND MORAXELLA CATARRHALIS INTRA- AND INTERSPECIES QUORUM SIGNALING
… to coexist than to be isolated individually. Polymicrobial infection and biofilm formation may have a dramatic impact on the severity and treatability of OM. Thus, there is a pressing need to investigate polymicrobial infection and to identify factors that contribute to the establishment of …
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Immunomodulation by subclinical persistent infection with Helicobacter hepaticus
Recognition of polymicrobial infections is becoming important for understanding differential host responses to environmental exposures, vaccines, as well as therapeutics. Citrobacter rodentium is a well-characterized model of infectious colitis with particular usefulness for modeling human …
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Studies of Three Human Intestinal Opportunistic Pathogens
… for use in examining bacterial synergy during a polymicrobial infection, and 3) Characterization of Escherichia coli 360A and evaluation of the role of several virulence factors and environmental modulators in the pathogenesis of this strain. We used a newly developed lux gene reporter to …
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Mechanisms of neutrophil recruitment in septic lung injury
… but potential therapeutic effect of them in polymicrobial sepsis remains elusive. Polymicrobial sepsis was induced by cecal ligation and puncture, purified monoclonal antibody against CD44, Rho kinase inhibitor (Y-27632) and Rac1 inhibitor (NSC23766). Specific TDPs, GKY20 and GKY25 were …
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Characterizing the Role of the Type VI Secretion System in Interbacterial Species Interactions and Pathogenesis
… them to compete for specific niches, persist in polymicrobial communities, and contribute to virulence and pathogenesis. One mechanism Gram-negative bacteria have adapted is the use of type VI secretion systems (T6SS). The T6SS is a large needle complex that spans across the entire bacterial cell …
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Identification of The Causative Bacteria In Musculoskeletal Infections Using 16S Rdna - Denaturing Gradient Gel Electrophoresis Analysis
… the majority of musculoskeletal infections are polymicrobial, which prohibits direct identification from the infected tissue by DNA sequencing of the initial 16S rDNA amplification products. One way to solve this problem is to use denaturing gradient gel electrophoresis (DGGE) to separate the …
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Bacterial Outer Membrane Vesicles. Mediators of virulence and antibiotic resistance.
… OMV secretion to be a mechanism for bacteria in polymicrobial infections to interact and protect each other. In summary, we determined that OMV secreted from Gram-negative bacteria of the upper respiratory tract are mediators of virulence and antibiotic resistance, interacting with host cells as …
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Mechanism of Candida Albicans Biofilm and Virulence Inhibition By A Bacterial Secreted Factor
<p>The human microbiome is a diverse polymicrobial population comprised of both fungi and bacteria. Perturbations of the normal microbiome can have a profound impact on health, including the development of infections. Exploitation of these polymicrobial interactions has the potential to provide …
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Lower respiratory tract infection in sudden unexpected infant deaths
Pneumonia due to polymicrobial infection is known to increase the severity and risk of fatality among young children. A retrospective study was undertaken on Sudden Unexpected Infant Death cases occurring, between 1 May and 30 September 2009, which were admitted to a medico-legal mortuary servicing …
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Induction of metronidazole and clindamycin resistance in gardnerella vaginalis
… vaginosis (BV) is known to be the most common polymicrobial vaginal disorder in females of childbearing age. It is characterised by a change in the healthy vaginal microbiome, from an environment dominated by hydrogen-producing lactobacilli, to the overgrowth of opportunistic pathogenic …
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