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Showing 1 to 11 of 11 for “"polymersome"”.
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Asymmetric Catalysis in Polymersome Nanoreactors
Contains fulltext : 140662.pdf (Publisher’s version ) (Open Access)
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Worm-shaped polymersomes and their effects on targeting efficiency
In order to improve the targeting efficiency of polymersomes with a given number of targeting molecules conjugated, efforts are being made to control particle shape. I hypothesized that worm-shaped polymersomes formed from self-assembly between poly(amino acid)s would have more targeting capability …
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Functional particles for controlled release and cell surface engineering
Engineered polymer vesicles (polymersome) have emerged as the new generation of molecular and cell carriers for a series of biomedical applications. These polymer vesicles typically present as hollow spheres that contain a hydrophilic core surrounded by a hydrophobic membrane, each of which can be …
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Delivery of Myoglobin Polymersomes Results in Tumor Hemorrhagic Necrosis and Enhanced Radiation Response
… carried out and evaluated through the use of polymersome-encapsulated myoglobin (PEMs) with the hypothesis that O2-releasing PEMs will increase tumor oxygenation, and thereby improve response to radiotherapy. Mb was chosen as an O2 carrying protein to deliver to tumors because it has a strong …
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Design and development of stimuli-responsive materials: pH sensitive polymersomes and poly(olefin sulfone)s
… of acid-triggerable covalently-crosslinked polymersomes and 2) the design and synthesis of base-, heat-, and fluoride-sensitive poly(olefin sulfone)s. Polymersomes are a useful approach for encapsulation but are susceptible to environmental stressors and leakage. By tuning the nanoscale …
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Fabrication of Polymersomes using Microfluidic Devices
… of diblock copolymer vesicles, so-called polymersomes, from poly(2-vinylpyridine)-block-poly(ethylene glycol) (P2VP-b-PEG) and poly(ethylene glycol)-block-poly(lactid acid) (PEG-b-PLA) by means of microfluidics is described. The experiments were performed in microfluidic devices made by …
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Reversibly Photo-Crosslinkable Polycarbonate-Based Polymersomes for Drug Encapsulation and Delivery
This thesis describes the preparation of polymersomes from poly(ethylene glycol)-block-polycarbonate (PEG-PC) copolymers functionalized with pendant coumarin groups. Coumarin groups undergo photo-reversible dimerization when irradiated with specific ultraviolet wavelengths, so they can be used to …
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ABC terpolymers : micelles, polymersomes and stabilisation of water in water emulsions
Polymersomes are vesicles formed from block copolymers. Their large internal volumes and thick walls make them very attractive for the encapsulation of different species. However, a major issue which prevents the use of polymersomes in most of the applications is that the encapsulation efficiency …
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Ellipsoidal polyaspartamide polymersomes with enhanced cell-targeting ability
Nano-sized polymersomes functionalized with peptides are being increasingly studied for targeted delivery of diagnostic and therapeutic molecules. Earlier computational studies have suggested that ellipsoidal nanoparticles, compared to spherical ones, display enhanced binding efficiency with target …
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Developing tissue engineered models of oral mucosa and oral cancer to study novel therapeutic and diagnostic techniques.
… spheroids were used to test the behaviour of polymersomes, a novel drug delivery system, in three dimensional tissues. Polymersome distribution and penetration in the tissue engineered models was examined over time, to investigate the potential of polymersomes to deliver therapeutic agents …
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Nanoemulsion-like Polymersomes for Nanoreactors
… Phase transfer of IL-filled polymer vesicles (polymersomes) from the IL phase to water produces a very stable kind of "nanoemulsion"�. Nanoemulsion-like polymersomes have great potential as they confine a catalyst within the interiors, thus mitigating the mass transfer limitations of ILs while …