Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"polymeric nanoparticle"”.
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Development of polymeric nanoparticle vaccines for immunostimulation
… slowly. This thesis serves to explore two polymeric nanoparticle platforms to demonstrate the therapeutic potential of synthetic nanocarriers as vaccines with the aim of 1) providing greater spatiotemporal release of small molecule adjuvant to secondary lymphoid sites and 2) providing a …
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An analysis of the size-control and uniformity of polymeric nanoparticle preparation techniques
Nanoparticles are bridge the gap between the micro and atomic scale and have found a variety of different used, especially in the drug-delivery field. This paper will break down some of the mot common methods for polymeric nanoparticle production.
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Polymeric nanoparticle as a new platform for high removal of endotoxins from biopharmaceutical solutions
… technology using a biocompatible polymer nanoparticle of approximately 800 nm diameter. The polymeric nanoparticle removed > 99% endotoxins from water, phosphate buffer saline (PBS) and protein solutions including monoclonal antibodies (MAb). It also showed a high protein recovery of ~99 …
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Targeting and Reprogramming Tumor-Associated Macrophages with Polymeric Nanoparticle-Mediated mRNA Delivery for Cancer Treatment
… have increasingly turned to versatile polymeric nanoparticles (PNPs). Compared with other nanocarriers like lipid- or inorganic-based nanoparticles, the adaptability and functionality of PNPs make them promising candidates for targeted drug delivery. In this study, we designed a PNP …
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Development of SiRNA Incorporated Surface Modified Polymeric Nanoparticle for the Potential Treatment of Global Cerebral Ischemia
… and suppress BRD4, this study developed PLGA nanoparticles coated with Polysorbate-80 (PS-80) and Polyethylene glycol (PEG) to incorporate siRNA and effectively deliver across the BBB. The study engineered siRNA-incorporated PLGA nanoparticles with PS-80 and PEG coating via a modified …
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Development of Soft-Matter Delivery Systems: Coupling pH Responsive Polymers to Porous Silica Particles
<p>This work investigates polymeric coating of evaporated induced self-assembly (EISA) mesoprous silica nanoparticles for potential use in controlled drug release and therapeutics. As demonstrated here, lipid bilayer coatings can be easily replaced with different polymer analogs allowing for …
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Tackling the Bottlenecks in Translational Nanomedicine: Towards Precision in Size Control and Facile Nanoformulation
… the immense research output, the translation of nanoparticle-based formulations into clinics has been limited. The efficient clinical translation of nanomedicine is impeded by several bottlenecks that include low targeting efficiency, imprecise size control, lack of scalable fabrication, rigorous …
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Designing nanoparticles for highly efficient endothelial siRNA delivery
… immune response. Despite these challenges, nanoparticles have delivered siRNA to hepatocytes after intravenous injections as low as 0.001 mg/kg. By contrast, efficient, durable, and robust silencing in other cell types has remained challenging. Herein we describe 7C I, a low molecular weight …
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Characterization of Everolimus In Biodegradable PLAF/PLEOF Nanoparticle
… vessels. Therefore, biodegradable core-shell polymeric nanoparticle (NP), with a hydrophobic core and hydrophilic shell was developed for surfactant-free encapsulation and delivery of Everolimus from DES. Elution of Everolimus was measured from Poly (lactide-fumarate)(PLAF) and Poly …
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Investigation of the absorptive potential of polymeric nanoparticles across the lungs and their development for efficient systemic delivery following pulmonary administration
… drug delivery of small molecules and proteins. Nanoparticles on the other hand have gained increasing interest in drug delivery due to the wide variety of advantages they possess that allow for temporal, spatial and targeted delivery of therapeutics that can be fine tuned for various …
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Development of orthogonal nanotherapeutics for colorectal cancer treatment
… reports the development of a novel dual-loaded polymeric nanoparticle-based cancer therapeutics co-encapsulating Entinostat and RG7388 at their optimal synergistic molar ratio to induce synergistic cell death. n vivo studies demonstrated that the nano-encapsulation of RG7388 and Entinostat …
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Photodynamically Activated Multifunctional Chitosan Nanoparticles to Disinfect and Improve Structural Stability of Dentin
… are twofold: 1) develop and test functionalized nanoparticles to eliminate biofilm bacteria and, 2) to stabilize and strengthen the dentin organic matrix by crosslinking collagen fibrils in the presence of biopolymeric nanoparticles. A bioactive polymeric nanoparticle functionalized with a …
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Antioxidant Nanoparticles as Delivery Systems
… goal of the study was to develop antioxidant polymeric nanoparticles as a new delivery system for food and pharmaceutical applications. Natural antioxidants like alpha-tocopherol, vitamin C, and carnosine, are responsible to protect biological systems against free radicals attack. The …
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Nanoparticles Targeting at Inflammation Site
… and translational evaluation of advanced nanoparticle-based drug delivery systems designed for the sustained and localized delivery of hydrophobic therapeutics, with a focus on pazopanib. Addressing key challenges in drug solubility, stability, and scalable manufacturing, this work …
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Self-assembled Polymeric Nanoparticles for Targeted Delivery of Anticancer Drugs
… The main goal of the project is to create a polymeric nanoparticle drug delivery system from synthesized biodegradable polymers and modify the polymeric nanoparticles using targeting antibodies for targeted delivery of anticancer drugs. A new biodegradable copolymer poly(2-methyl, 2-carboxy …
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Poly(LA-co-TMCC)-graft-PEG Self-assembled Polymeric Nanoparticles for Targeted Drug Delivery
Polymeric nanoparticles have gained increased popularity for drug delivery as they not only overcome the problem of limited aqueous solubility of many hydrophobic drug molecules, but also have the potential to improve the pharmacologic properties of anticancer drugs by increasing their in vivo …
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Tools for decoding the structure-function relationships of biopolymers in nanotechnology and glycobiology
… platform for accurately simulating all phases of polymeric nanoparticle erosion and drug release is introduced. Using the developed Voxel platform, the release of anti-inflammatory and anti-cancer drugs such as doxorubicin and dexamethasone from poly lactic-co-glycolic acid (PLGA) nanoparticles is …
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Engineered Nanomaterials for Targeted Imaging and Therapy
… survival. The unique and tunable properties of nanoparticles facilitate the development of diagnostic imaging tools for earlier diagnosis and disease staging, and they can provide fundamental information on the pathological process. Nanoparticle probes have demonstrated to have numerous …
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Development of nanoparticles for oral delivery of insulin
… of drugs across the intestinal epithelium. Polymeric nanoparticle (NP) carriers provide new opportunities for controlled delivery of drugs, and have the potential to address challenges associated with effective oral delivery of insulin. NPs can protect the protein therapeutic from …
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Conjugation of Anti-HER2 Monoclonal Antibody onto a PLGA-PEG Nanoparticle Using CuAAC Click Chemistry
… the antibody selected. In this work a PLGA-PEG nanoparticle was attached covalently to an anti-HER2 monoclonal antibody via click chemistry. The targeting ability of the conjugated system was analyzed via flow cytometry and fluorescent microscopy to determine its effectiveness and activity.</p> …
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