Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"polymeric nanocarriers"”.
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Polymeric nanocarriers with dendritic core-shell architectures
Hyperbranched polymers, polyglycerol and polyethylenimine, were functionalised in order to tailor systems that can be used in medical applications. The systems described in this thesis can be used for pH controlled release of drug molecules and were also investigated towards their gene transfection …
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Development of Polymeric Nanocarriers for Dual Magnetic Resonance Imaging and Drug Delivery
Two types of (polymer-imaging agent-drug) complexes were prepared and characterized. These included block and graft copolymer complexes with magnetite nanoparticles and manganese ions. Magnetite block ionomer complexes (MBICs) were formed through binding of a portion of the anionic segment of …
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Polymeric nanocarriers for the regional and systemic delivery of therapeutics to and through the lungs
… including lung cancer and tuberculosis. Polymeric nanocarriers (PNCs) have several advantages over other drug delivery vehicles including sustained release of moieties, ease of cellular internalization and improved targeting, and hence hold the promise to greatly augment the potential of …
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Polymeric Nanocarriers And Their Oral Inhalation Formulations For The Regional Delivery Of Nucleic Acids To The Lungs
… been hampered largely by the lack of efficient nanocarriers capable of overcoming the lung structure, the extra and intracellular barriers present in the lung tissue, and formulation challenges - aerodynamic particle size, surface chemistry of the particles, and solvation forces in …
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Biophysical characterization of hydrogel-core, lipid-shell nanoparticles (nanolipogels) for HIV chemoprophylaxis
… capabilities to encapsulated cargo. Polymeric nanoparticles made from poly(lactide-co-glycolide) (PLGA) are biodegradable, exhibit tunable drug release, and have encapsulated a wide variety of biological agents. However, PLGA nanoparticles are relatively inefficient at encapsulating …
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Dendrimer Nanoconjugates And Their Oral Inhalation Formulations For Lung Cancer Therapy
… these discussed challenges, we used a strategy — polymeric nanocarriers (PNCs) to achieve the spatial and temporal drug release and local delivery of drug to the lungs. In this work, we desgined polyamidoamine dendrimer (PAMAM) conjugates which can only release DOX intracellularly, while being …
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Dendrimer Based Nanotherapeutics For Ocular Drug Delivery
… are a class of well-defined, hyperbranched polymeric nanocarriers that are being investigated for ocular drug and gene delivery. Their favorable properties such as small size, multivalency and water solubility can provide significant opportunities for many biologically unstable drugs and …
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The Design of Biodegradable Polyester Nanocarriers for Image-guided Therapeutic Delivery
… bioavailability of many promising therapeutics. Polymeric nanocarriers can encapsulate the therapeutics to protect non-target areas from side effects but also protect the drug from premature degradation for increased circulation and bioavailability. To capitalize on these advantages, the polymer …
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Nanotherapies for Treating Prostate Cancer
… for treating prostate cancer and develop polymeric nanocarriers to facilitate anticancer drug and nucleic acid delivery.</p> <p>It was hypothesized that simultaneously targeting androgen-androgen receptor (AR) and X-linked inhibitor of apoptosis protein (XIAP) signaling pathways would be …
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Design of functional polymeric materials for cancer-targeted drug delivery and cellular capture and isolation
Synthetic polymeric materials offer many exciting advantages with the plethora of functionalization techniques affording materials with unique properties, multiple functionalities, and elaborate architectures for a variety of applications. In the drug delivery field, the use of synthetic polymers …