Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"polymeric immunoglobulin receptor (pIgR)"”.
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Structural studies of the human polymeric immunoglobulin receptor
The human polymeric immunoglobulin receptor, pIgR, is a glycosylated type I transmembrane protein expressed on the basolateral surface of secretory epithelial cells. pIgR plays a key role in mucosal immunity and, together with bound immunoglobulins (Igs), provides a first line of specific defense …
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Limiting host-microbiota interactions to control intestinal inflammation
… by epithelial cells after binding to the polymeric immunoglobulin receptor (pIgR), and is limited by the rate of pIgR expression and translocation. Th17 cells can directly induce pIgR expression from intestinal epithelial cells, and increase levels of luminal IgA. During episodes of …
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Characterization of Fc receptor family proteins in vaginal and endocervical epithelia
… of my research project was to characterize Fc receptor expression in epithelial cell models of the lower female genital tract with a particular focus on the neonatal Fc receptor (FcRn). Fc receptors are a large family of proteins that bind to the Fc region of immunoglobulins (Igs) and function …
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Host-Microbial Interactions that Modulate Luminal IgA
<p>IgA is the most abundant immunoglobulin produced in the body, most of which can be found at mucosal sites such as the intestine where it plays an important role at a critical intersection between the host immune system and the microbiota. In the work detailed here, I sought to investigate IgA …
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Studies of immunoglobulin receptors and human proximal tubular cells
… higher molecular weight proteins such as immunoglobulins (Ig) are more associated with progression of renal disease. In this thesis I have explored the hypothesis that an interaction between tubular cells and filtered Ig/immuno complex (Ig/IC) may involve specific cellular receptors, and …