Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"polymeric gene delivery"”.
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Raft Polymerization Of Ph-Responsive, Diblock Copolymers For Nucleic Acid Delivery Vehicles
Since the development of gene therapy, a variety of non-viral nucleic acid delivery vehicles have been prepared and studied for their transfection efficiencies. Recently, polymeric gene delivery vehicles have gained popularity for their low immunogenicity and high transfection efficiency. With the …
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Elucidation of Design Criteria for Non-Viral Gene Delivery Vector Development
… finally transcription all stand as obstacles to gene delivery. The research presented in this thesis addresses the issue of gene delivery efficiency by studying vector dissociation and endocytosis. Chapter 2 examines dissociation by reducing the electrostatic interaction between DNA and the …
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Synthesis and application of biomaterials containing the 1,3,5-triazaadamantane moiety or functionalized alginate
… divergent strategy, dendrimers up to three generations were synthesized that contained 39 TAA monomer units, displayed 81 functional groups on its periphery, and had a molecular weight above 35 kDa. End group modification with propargyl alcohol initiated hyperbranched polyglycerol rendered …
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Preparation and analysis of novel tumour-targeted delivery systems for prostate cancer therapy
… therefore critically needed for these patients.Gene therapy holds great promise for the intravenous treatment of prostate cancer. Non-viral gene delivery is emerging as potential safer alternative to the use of viral vectors for the treatment of various gene related diseases including cancer. …
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Characterization of Intermolecular Interactions in Nanostructured Materials
… and temperature-dependent hydrogen bonding in polymeric systems. ITC was successfully used to determine the low critical micelle concentration (CMC) for a novel gemini surfactant with limited water solubility. CMCs were measured at decreasing methanol molar fractions (xMeOH) in water and the …