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Showing 1 to 20 of 1522 for “"polymerase"”.

  1. [RNA polymerase ribozymes]

    Lawrence, Michael S. (Michael Scott), 1975-Massachusetts Institute of Technology2005

    … we isolated nine distinct classes of polymerase ribozymes. Two of these rudimentary polymerases were further evolved to the point that they each could add 14 nucleotides to an untethered primer-template. One of them was subjected to a detailed further characterization. The …

    mit Repository record

  2. The Characterization of Mip1 DNA Polymerase

    Lucas, Thomas Paul2021

    … their own DNA outside of the nucleus. A single polymerase is primarily responsible for the replication and repair of mtDNA. In humans and other animals, this enzyme is known as polymerase gamma (Pol γ) and it is orthologous to Mitochondrial DNA Polymerase 1 (Mip1) from Saccharomyces cerevisiae. …

    tdl Repository record

  3. The Characterization of Mip1 DNA Polymerase

    Lucas, Thomas PaulThe University of Texas Medical Branch at Galveston2021

    … their own DNA outside of the nucleus. A single polymerase is primarily responsible for the replication and repair of mtDNA. In humans and other animals, this enzyme is known as polymerase gamma (Pol γ) and it is orthologous to Mitochondrial DNA Polymerase 1 (Mip1) from Saccharomyces cerevisiae. …

    utmb Repository record

  4. Fluorescence assay for polymerase arrival rates

    Che, Austin, 1979-Massachusetts Institute of Technology2004

    … and characterization strategies. The RNA polymerase arrival rate (PAR) is defined to be the rate that RNA polymerases arrive at a specified location on the DNA. Designing and characterizing biological modules in terms of RNA polymerase arrival rates provides for many advantages in the …

    mit Repository record

  5. Expanding the Scope of the T7 RNA Polymerase - A Novel Plasmid Requires T7 Rna Polymerase for Replication

    Becker, KatjaETH Zurich2017

    ethz Repository record

  6. Mechanismus der Polymerase-Inkorporation in foamyvirale Partikel

    Peters, KatrinUniversität Würzburg

    In allen Retroviren, mit Ausnahme der Foamyviren (FV), wird das Pol-Protein als Gag-Pol-Fusionsprotein exprimiert. Dieser Mechanismus sichert die Inkorporation von Pol in das virale Partikel. FV unterscheiden sich in vielen Merkmalen von den Orthoretroviren, unter anderem wird das Pol-Protein von …

    wurz-thes Repository record

  7. Structure-Function Studies Of The Poliovirus Polymerase.

    Jablonski, Sandra A

    uab Repository record

  8. Cryo-EM Studies of Bacterial RNA Polymerase

    Chen, James

    <p>In bacteria, a single RNA polymerase (RNAP) performs all transcription. The overall structure of bacterial RNAP resembles a crab claw with pincers comprising the β' and β subunits and a large cleft where the active site sits. Structural information about this essential enzyme has mainly been …

    rockefeller Repository record

  9. Structural and Computational Studies of RNA Polymerase

    Lane, William J

    <p>Although the multi-subunit RNA Polymerase (RNAP) structures have revolutionized our understanding of transcription, we still do not fully understand the molecular details of bacterial promoter recognition and melting. In addition, our understanding is generally limited to highly conserved …

    rockefeller Repository record

  10. Silaffin Tagged Polymerase for Nucleic Acid Amplification

    Seevaratnam, DushanthUniversity of Cambridge2020

    … Geobacillus stearothermophilus (BST) DNA polymerase capable of low-cost purification, ease-of-use, and compatible with sensitive and specific loop mediated isothermal amplification (LAMP) assays. Fusing the enzyme with a silaffin tag (R5) and a fluorescent protein (mCherry) enabled rapid …

    cambridge Repository record

  11. RNA polymerase II holoenzyme components and regulation

    Wilson, Christopher J. (Christopher John), 1971-Massachusetts Institute of Technology1999

    Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Biology, 1999.

    mit Repository record

  12. Yeast and mammalian RNA polymerase II holoenzymes

    Chao, David M. (David Min)Massachusetts Institute of Technology1997

    Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1997.

    mit Repository record

  13. A novel capillary polymerase chain reaction machine

    Chiou, Jeffrey TsungshuanMassachusetts Institute of Technology2001

    I built a novel prototype capillary polymerase chain reaction machine. The purpose was to perform a single reaction as fast as possible with a reaction volume - 100 nl. The PCR mix is in the form of a 1 /1 droplet that moves between three heat zones inside of a 1 mm I.D. capillary filled with …

    mit Repository record

  14. Determinants of Rotavirus Polymerase Localization and Activity

    McKell, Allison OverstreetVirginia Tech2017

    … many stages of viral replication occur. The RV polymerase, known as VP1, must localize to viroplasms during infection where it replicates the virus' RNA genome. The work described in this dissertation focused on identifying region(s) of VP1 essential for its viroplasmic localization and its …

    vt Repository record

  15. Molecular analysis of cyanobacterial RNA polymerase genes

    Xie, WenQinVirginia Polytechnic Institute and State University1989

    The RNA polymerase genes rpoBC1C2 (the rpoB and rpoC2 are incomplete) of the cyanobacterium Nostoc commune have been cloned, sequenced, and expressed both in vivo and in vitro using E. coli systems. The rpo genes encode large subunits of DNA-dependent RNA polymerase. Two genes in N. commune, rpoC1 …

    vt Repository record

  16. Mcm10 regulates the turnover of DNA polymerase alpha.

    Haworth, Justin Christopher2010

    … shown that Mcm10 regulates the stability of DNA polymerase (pol) alpha/primase, the only enzyme capable of de novo DNA synthesis, in yeast and humans. In the absence of Mcm10, Cdc17, the catalytic subunit of pol alpha, is rapidly degraded. We have determined that Cdc17 degradation is dependent on …

    umn Repository record

  17. φ 6 polymerase conformation; RNA packaging portal stability.

    Futerman, Elena

    cuny Repository record

  18. Regulation of yeast RNA polymerase II holoenzyme transcription

    Hengartner, Christoph J. (Christopher Johannes), 1968-Massachusetts Institute of Technology1999

    Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Biology, 1999.

    mit Repository record

  19. Determinants of Core Shell Dependent Rotavirus Polymerase Activity

    Steger, Courtney LongVirginia Tech2019

    … in many countries. The RV RNA-dependent RNA polymerase, VP1, synthesizes RNA during viral replication only in the presence of another RV protein, VP2, which comprises the innermost core shell layer of the virion. Though these VP1-VP2 interactions are essential for RV replication, the …

    vt Repository record

  20. Role of basic and hydrophobic residues in the poliovirus polymerase elongation complex and the structure of a coxsackievirus polymerase elongation complex

    Kortus, Matt, author, Peersen, Olve, advisor, Ho, P. Shing, committee member, Suchman, Erica, committee memberColorado State University. Libraries2011

    … encode for and require a viral RNA-dependent RNA polymerase (RdRP) for genome replication. This enzyme synthesizes negative-sense RNA from the infecting positive sense genome producing a replicative intermediate. The negative sense RNA then serves as a template for synthesis of additional …

    colostate Repository record

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