Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"polymer scaffold"”.
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Biodegradable polymer scaffold fabrication and the creation of tissue-engineered bone
… cell transplantation within porous biodegradable polymer foam scaffolds. The work presented in this thesis was aimed at creating a porous biodegradable scaffold with appropriate mechanical properties, which in concert with an appropriate vascular environment, would be sufficient to create tissue …
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Development of Combinatorial Strategies Employing Neural Stem Cells and Polymer Scaffold for Spinal Cord Repair
… Strategies Employing Neural Stem Cells and Polymer Scaffold for Spinal Cord Repair Stem cell-based therapy holds promise to enhance functional recovery following spinal cord injury (SCI). Most evidence that transplantation of neural stem cells can produce beneficial outcomes after SCI has …
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The design of a molecular assembly line based on biological molecules
… as well as its potential uses as a universal polymer scaffold in programmed assembly and molecular electronics. It is based on the principles of the biological molecules polyketide synthase and kinesin, and in some embodiments, may employ biomolecules like DNA as components of the system. The …
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A novel osteochondral composite consisting of a self-assembling peptide hydrogel and 3D printed polycaprolactone scaffold : potential for articular cartilage repair
… porous 3D printed polycaprolactone (PCL) scaffold to create a novel osteochondral construct. The self-assembling peptide hydrogel has been shown to provide an environment that maintains chondrocyte phenotype and viability. Furthermore, the 3D scaffold fosters extracellular matrix …
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The detection of nitric oxide and its reactivity with transition metal thiolate complexes
… relevant applications by including it within a polymeric film. We have also developed turn-on fluorescent sensors for NO based on conjugated polymers, which demonstrated good selectivity and sensitivity for this analyte. In addition, we have prepared a related sensor that will detect nitroxyl …
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Dynamic plasma photonic crystals: multidimensional electromagnetically active artificial structures in the mm-wave and thz regimes
… (3D) complex microcapillary networks within a polymer scaffold. Generation of plasma within these microcapillaries formed dynamic 3D plasma photonic crystals with electronic speed tunability. Metallic gratings were interwoven with microplasma columns to form dual resonators that modified the …
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Microenvironmental Modulation of Breast Cancer Stem Cells Through Biological Matrix
… </p> <p>In chapter two, we fabricated 3D fibrous scaffold utilizing electrospinning technique. Polymer scaffold with varying composition and orientation were created by this method. Wavy microfeatures were fabricated by oxygen plasma treatment on polydimethylsiloxane (PDMS) films. 2D thin films …
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Property determination of biomedical polymer scaffolds for cervical tissue repair
… the mechanical properties of a nano-scaled polymer scaffold based on the porcine uterine cervix (PUC). The permeability and mechanical properties of electrospunned polyurethane scaffolds of two different polymer grades, Z1A1 and Z3A1, were investigated in order to explore the possibilities …
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Characterization of the early stages of long bone regeneration in fractures and critical size defects in Xenopus Laevis
… to study the effect of two biocompatible scaffolds, an artificial polymer scaffold (HDDA) and a protein (zein) scaffold, on regeneration of long bone defects in adult African Clawed Frogs (Xenopus laevis) hind limbs. The HDDA scaffolds loaded with growth factors BMP4 and VEGF and zein …
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I. Macromolecular and architectural effects on the polymerization of α-helices & II. Functional ROMP curing polyester thermosets
… question, my research has demonstrated that polymer systems can utilize cues given by their architecture to alter their behavior. In more specific terms, I have shown that polymer kinetics can be governed by not only secondary structure, but also tertiary structure. Utilizing …
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Formation of Cyclodextrin-Drug Inclusion Compounds and Polymeric Drug Delivery Systems using Supercritical Carbon Dioxide
… methods for the preparation of porous biomedical scaffolds have been explored for applications in tissue engineering and drug delivery. Scaffolds with controlled pore morphologies have been generated which incorporate cyclodextrin-drug inclusion complexes as the drug delivery component. …
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Towards high performance graphene nanoelectronics: materials, contacts and interfaces
… We investigate large-scale CVD-grown polymer-transferred graphene quality issues and characterize device-to-device variability. We optimize a polycarbonate based polymer scaffold, used for mechanical support and protection during graphene transfer, and a vacuum annealing process in …
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Green manufacturing in the medical device industry : a case study
… Med Dev's first generation technology is a polymer scaffold that will be inserted into the injury site immediately post injury during a routine procedure. The scaffold prevents secondary injury (bruising and scarring) formation by filling the void space left by the injury, promoting cell …
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Synthesis and applications of core functional hyperbranched polyglycerol
… describes two methods for the synthesis of the polymers and its formal [3+2] cycloaddition with organic azides in the presence of copper, commonly referred to as click chemistry. The two methods allow preparation of low molecular weight polymers, MW < 10,000 g/mol and high MW > 100,000 g/mol. …
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Design of multidimensional microplasma array for biofilm removal and dynamic photonic crystals
… a 3D network of microchannels fabricated in the polymer, the result is a transient double crystal in which the microplasma network and polymer scaffold are coupled. The enhanced spatial and temporal coupling offer the capability to electronically control the electromagnetic response, including …
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Characterization and Implementation of a Decellularized Porcine Vessel as a Biologic Scaffold for a Blood Vessel Mimic
… of testing intravascular devices. However, the scaffold component of this model exhibits several physiological limitations that must be addressed to create a truly biomemtic BVM. The current model uses expanded poly(terafluorethylene) [ePTFE] or poly(lactic-go-glycolide) [PLGA] as the choice …
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Dynamics of super-absorbent hydrogels
… class of materials comprising a hydrophilic polymer scaffold surrounded by adsorbed water molecules, potentially comprising over 99% water by volume. In general, hydrogels are soft, elastic, porous materials that can swell or dry to a significant degree by imbibing or expelling water. Any …
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Multi-scale characterization of swine femoral cortical bone and long bone defect repair by regeneration
… study the effect of a biocompatible artificial polymer scaffold on regeneration of long bone defects in adult African Clawed Frogs (Xenopus laevis) hind limbs. We first designed and fabricated scaffolds made of 1,6 hexanediol diacrylate (HDDA) using an innovative three dimensional …
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Bioelectronic in vitro models for monitoring intestinal host-pathogen interactions
… native plasma membrane vesicles onto conducting polymer microelectrode arrays, a direct comparison of the susceptibility of apical and basal membranes to alpha hemolysin toxin is made, in addition to the investigation of pathogenic extracellular vesicles interacting with the host cell membrane. …
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