Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 47 for “"polymer physics"”.
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Blood clotting inspired polymer physics
… observed in this process within the context of polymer physics. By understanding these physical principles, we hope to harness nature's ability to both direct molecules in both spatial and conformational coordinates. This thesis is presented in three complementary sections. After an initial …
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Multiscale Modeling of Genome Organization: Bridging Polymer Physics, Molecular Dynamics, and AI
… implications. We introduce data-driven, physics-based, and generative artificial intelligence modeling approaches, highlighting the need for interpretable and efficient models capable of capturing the structural diversity of the nucleus across individual cells. In Chapter 2, we present …
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Polymer dynamics and fluctuations probed with fluorescence methods
The arc of the thesis is direct measurement of polymer chain properties with potent fluorescence methods imported from other interdisciplinary sciences and applied successfully to polymer physics problems for the first time. The focus is an important theme in equilibrium polymer physics - chain …
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Interactions and Dynamics of Soft Materials
… large part of my dissertation is related with polymer interfacial dynamics. As one of the center topics of polymer physics, many models have been generated to understand polymer dynamics in bulk solutions and in melt. However, to study the dynamics of polymer at the interfaces is more …
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Seeing the unseen dynamics in soft matter
… the dynamics of vesicle membranes, interfacial polymers, colloidal particles. Optical imaging was applied three distinct systems to reveal the underlying physical processes that were hindered by other prior indirect measurements. First, mechanical responses of both polymer and lipid vesicles …
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Dynamic Simulation of active/inactive Chromatin Domains
… order chromatin structures with the help of polymer physics for the first time. It is a block-copolymer model for the compactification of the 30nm Chromatin fiber into higher order structures. The idea is that basically every condensing agent (HMG/SAR, HP1, cohesin, condensin, DNA-DNA …
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Nanofluidic Channels for Biological Separations
… Important concepts in molecular biology, polymer physics, and electrophoresis are presented, as well as a review of the trend toward miniaturization of traditional separation techniques. The physical effects manifest in the nanofluidic devices described herein are most easily leveraged in …
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Modeling Genome Organization in Eukaryotic and Prokaryotic Cells Using Folding Determinant Interactions
… in disentangling stochastic folding driven by polymer physics from specific interactions mediated by nuclear landmarks and regulatory factors. In this thesis, I develop polymer-based chain-growth Monte Carlo frameworks to investigate genome folding in both mammalian and bacterial systems. For …
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Quantum computing for biophysical and optimization problems
… we focus on two particularly challenging biophysics problems: protein design and polymer sampling. Protein design involves engineering the primary sequence of a protein to ensure that it folds into a specific target conformation of biological interest. Our approach employs a physics-based …
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Chain dynamical theories of protein folding
… chain: the glassy dynamics expected for heteropolymers with random interactions and the organized dynamics expected for minimally frustrated proteins that fold rapidly on a funneled landscape. The chain dynamical phenomena relevant to both these extremes are studied in this thesis. First, we …
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Direct Measurements of Polyelectrolyte Brush Responses using Atomic Force and Optical Microscopy
… of the response properties of these polymer surfaces. For that purpose new methods are developed which combine force spectroscopy and optical microscopy. As well, established physico-chemical techniques are used. Polymer brushes provide an excellent building block for responsive …
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Intrinsically Disordered Protein Polymer Libraries as Tools to Understand Protein Hydrophobicity
<p>Intrinsically disordered protein polymers (IDPPs) are repetitive biopolymers that, when enriched with prolines, glycines, and aliphatic amino acids, have observable lower critical solution temperature (LCST) phase transition behavior at physiologically relevant temperature and concentration …
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Force-response statistics of semiflexible polymers
… to probe the physical properties of these biopolymers in unprecedented detail. These methods have led to a greater understanding of a wide range of biologically relevant processes, including the dynamics of cytoskeletal filaments, the stability of DNA double helix, and the formation of …
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Studies of DNA dynamics in slit-like nanochannel confinement
… has greatly improved our understanding of polymer physics, from gel electrophoresis to the theology of dilute (and even concentrated) polymer solutions. The use of DNA in these general studies, though, resulted in a depth of specific knowledge concerning a particular polymer of major …
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Modeling Disorder in Proteins Yields Insights into the Evolution of Stability and Function
… and abundant. Recent advances in heteropolymer theory unveiled a powerful set of sequence patterning metrics that bridge the gap between intra-molecular interaction and chain conformation. Specifically - charge patterning has been identified as a dominant mechanism behind IDP …
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Computational Studies of Bio-Inspired Synthetic Random Heteropolymers
Biological heteropolymers, such as proteins and nucleic acids, work together to execute the vast suite of tasks which ultimately enable life. These capabilities, particularly enzymatic function, are incredibly attractive for developing sustainable materials, removing pollutants and contaminants, …
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Ion Aggregation, Correlated Ion Transport and the Double Layer in Super-Concentrated Electrolytes
… in water-in-salt electrolytes that unravels the physics behind a potential mechanism for oxidative stability in WiSEs. We find that asymmetric ion solvation leads to very asymmetric water distributions within the double-layer. Next, we develop a thermodynamic model of ion aggregation and …
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Complex mechanical design of bio-inspired model transient network hydrogels
… material function. We draw from classical polymer physics and metal-coordinate chemistry to show that our 4-arm polyethylene glycol-based hydrogels crosslinked with transient histidine:metal bonds represent a uniquely ideal system for probing fundamental questions in how the properties of …
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Constitutive modeling of glassy memory polymers
… constitutive model for glassy shape memory polymers are addressed in detail. Shape memory polymers are novel material that can be easily formed into complex shapes, retaining memory of their original shape even after undergoing large deformations. The temporary shape is stable and return to …
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Microscopic theory for dynamics in entangled polymer nanocomposites
… microscopic theories for describing dynamics in polymer nanocomposites are developed and applied. The problem is addressed from two distinct perspectives and using two different theoretical approaches. The first half of this dissertation studies the long-time and intermediate-time dynamics of …
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