Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"polymer nanoparticles"”.
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Design of Single-Chain Polymer Nanoparticles to Mimic Globular Proteins
… alternatives with higher stability. Single-chain polymer nanoparticles (SCNPs) based on random heteropolymers (RHPs) have emerged as a promising platform as both protein stabilizers and mimetics. However, theoretical understanding of the origins underlying their functional versatility has lagged …
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Dye-doped polymer nanoparticles for flexible, bulk luminescent solar concentrators
… energy transfer efficiency of the dye-doped nanoparticles was found to be 8 7% for lwt%/lwt% doping of Coumarin 1 (C1) and Coumarin 6 (C6). In the solid state, however, energy transfer is lost, reducing to 32.8% and 20.1% respectively for the C1(lwt%)/C6(lwt%) and C1(0.5wt%)/C6(lwt/ ) …
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Infululence of Polymer Nanoparticles on the Dewetting of Polymer Thin Films
The influence of polystyrene star based nanoparticles on the dewetting of spun-cast linear polystyrene (PS) films on Si/SiOx surfaces is investigated as a function of temperature, concentration and type of the nanoparticles. The star polymers have polystyrene-benzocyclobutene copolymer arms which …
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TARGETED POLYMER NANOPARTICLES FOR THE DETECTION AND TREATMENT OF DISSEMINATED COLORECTAL CANCER IN VIVO
Colorectal cancer (CRC) is the second leading cause of cancer-related deaths and the fourth most common cancer in the United States. When CRC disseminates into the abdominal cavity, there can be hundreds, if not thousands, of small tumors infiltrating the surfaces of organs, making it extremely …
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In vitro and in vivo imaging of peptide-encapsulated polymer nanoparticles for cancer biomarker activated drug delivery
… of a new cancer drug delivery system based on nanoparticles, which is designed to target tumor sites better than previous practices. In this study, nanoparticles coated with cathepsin D-specific peptides were developed as a vehicle for the targeted delivery of the cancer drug doxorubicin (DOX) …
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Evaluation of polyelectrolyte multilayer thin-film coated microneedle arrays for transcutaneous vaccine delivery
… has the advantage of direct delivery of DNA or polymer nanoparticles to immune-active cells at the interface between the dermis and epidermis, enhancing uptake of the delivered cargo by resident immune cells. Ideal for the delivery of DNA vaccines, this platform aims to bridge the gap in the …
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Biocompatible polymeric nanoparticles for drug/DNA delivery using biologically friendly polymerisation processes
… explores the synthesis of several different polymeric nanostructures using reversible addition-fragmentation chain transfer (RAFT) polymerisation in both aqueous and ethanolic solutions.<br/><br/>A preface entailing an abstract, contents, common abbreviations and details of where this work …
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Metal-polymer nanoparticulate systems for externally-controlled delivery
Metal-polymer nanocomposites consisting of gold nanorods and temperature-responsive hydrogel nanoparticulates were investigated for use in externally-controlled drug delivery systems. Several different thermo-responsive hydrogels including poly(N-isopropyl acrylamide) (PNIPAAm) and …
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Photoactivatable Organic and Inorganic Nanoparticles in Cancer Therapeutics and Biosensing
… were addressed by the development of conducting polymer nanoparticles as a next generation of photosensitizers. This choice was motivated by the fact that conducting polymers have large extinction coefficients ( > 107 L mol-1 cm-1), are able to undergo intersystem crossing to the triplet state, …
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Synthesis and process optimization of colloidal unimolecular polymer, cup, particle formation, and its interfacial surface tension behavior
<p>"Colloidal Unimolecular Polymer (CUP) particles are 3-9 nm size single-chain polymer nanoparticles that are made from amphiphilic acrylic co-polymers using the process of water reduction. The formation of CUP particles was driven by the polymer-polymer interactions being greater than …
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Vat Photopolymerization of High-Performance Materials through Investigation of Crosslinked Network Design and Light Scattering Modeling
… limits the accessible properties for vat photopolymerization (VP) materials required for engineering applications. This has limited the adoption of VP for producing end-use parts, which typically require high MW polymers and/or more stable chemical functionality. Decoupling the viscosity and …
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Synthesis and Characterization of Drug-Containing, Polysaccharide-Based Nanoparticles for Applications in Oral Drug Delivery
… solid dispersions of polysaccharide-drug nanoparticles were produced by a rapid precipitation process known as flash nanoprecipitation and the formulation process and properties of nanoparticles were investigated. In this thesis, several novel cellulose derivatives and a pullulan …
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Reversible chemistry to control the synthesis and folding of polymeric materials
… to control the synthesis and folding of polymeric materials Jorge Gomez Magenti Mimicking Nature’s ability to create well-defined functional materials is a major goal in the field of polymer chemistry. Two distinct approaches are explored in this work. Part I of the thesis deals with the …
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Semiconducting Polymer Nanospheres: Organic Alternatives to Inorganic Quantum Dots?
Semiconducting polymer nanospheres are organic conjugated polymer nanoparticles which are synthesized from benign materials and exhibit excellent fluorescence properties. The nanoparticles are generally larger than inorganic quantum dots with a relatively broad size distribution. Quantum dots, on …
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Towards understanding RAFT aqueous heterophase polymerization
… technique for studying the aqueous heterophase polymerization. The polymerization rates obtained by calorimetric investigation of ab initio emulsion polymerization of styrene revealed the strong influence of the type and combination of the RAFT agent and initiator on the polymerization rate and …
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Small Solutions to Big Problems: Design and Synthesis of Nanoparticles for Biomedical Applications
Nanoparticles have the potential to revolutionize medicine, but many obstacles complicate the translation of nanoparticles from the bench to the clinic. A deeper understanding of nanoparticle synthesis parameters that influence nanoparticle size, drug loading, and surface chemistry is needed to …
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Silica Microspheres Functionalized with Self-assembled Nanomaterials
… that possess second order nonlinearities, Au nanoparticles (NPs) that support plasmonic resonances, and fluorescent materials such as CdSe/ZnS core/shell QDs. A major part of this thesis is to investigate the relationship between cavity Q factors and the amount of nanomaterials deposited onto …