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Showing 1 to 16 of 16 for “"polymer microspheres"”.
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Polymer microspheres for vaccine delivery
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1996.
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Improved swellable polymer microspheres for chemical sensing
<p>Derivatized lightly crosslinked polymer microspheres that swell and shrink as a function of pH have been investigated to develop polymeric transduction elements for fiber optic sensors and other sensors. The microspheres were immobilized in hydrogels forming a membrane. The membranes look turbid …
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Magnetoacoustic chemical sensors based on swellable polymer microspheres
… of magnetoacoustic sensors based on swellable polymer microspheres. The magnetoacoustic sensor was used to monitor viscosity of starch solution, water loading, and 2-hydroxyethyl methacrylate polymerization.</p><p>Poly(vinylbenzyl chloride) (polyVBC) microspheres were prepared by suspension …
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Development of environmentally benign microencapsulation with polymer microspheres and liposomes
… In this work, aqueous liposome systems and polymer based encapsulation of fine particles in supercritical CO_2 were studied. Compared to many other microencapsulation methods, these two methodologies feature reduction/prevention of using organic solvents, making them particularly attractive …
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The sustained delivery of antisense oligodeoxynucleotides using biodegradable polymer microspheres
… reduce dose required for efficacy. Biodegradable polymer microspheres were evaluated as delivery devices for ODNs and ribozymes. Poly(lactide-co-glycolide) polymers were used due to their biocompatibility and non toxic degradation products. Microspheres were prepared using a double …
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Modeling of controlled-release drug delivery from autocatalytically degrading polymer microspheres
… performance for the case of drug release from microspheres of different sizes is presented to highlight the capability of the model for predicting size-dependent, autocatalytic effects on the polymer and the release of drug.
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Chemical sensors based on swellable molecularly imprinted polymer microspheres in a hydrogel
… sensors based on swellable molecularly imprinted polymer microspheres is presented. These sensors were successfully used to measure norephedrine and theophylline in water and in buffer at neutral pH.</p><p>A new method was developed for preparing swellable norephedrine templated poly …
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Chemical sensors based on swelling polymer microspheres and uncrosslinked fluorescently-labelled molecularly imprinted polymers
<p>Polymer swelling can be achieved by derivatizing a functional group onto the polymer that selectively binds a particular analyte. For example, at low pH, the particles in a hydrogel membrane swell in response to the increased hydrogen ion concentration and the membrane reflects less light. When …
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Preparation and evaluation of polymer microspheres for enhanced lateral flow immunoassay: the case study for malaria
… that the development of a new high capacity polymer microsphere technology, termed ReSyn, could be developed as viable detection reagents for lateral flow technology. This body of work outlines the development of this new high capacity polymer microsphere technology for suitability to flow on …
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Selective assembly in deformable systems using templated assembly by selective removal
… of successful assembly of deformable polymer microspheres on patterned rigid substrates using Templated Assembly by Selective Removal (TASR). Also presented is a quantitative model for predicting the successful self-assembly of deformable materials using TASR. Successful assembly of …
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Modeling and validation of a syntactic foam lining for noise control devices for fluid power systems
… is a urethane host matrix with embedded hollow, polymer microspheres. The material properties at elevated pressure are unknown by the liner manufacturer, but are known to be pressure- and temperature-dependent. Therefore, the effect of hydrostatic pressures from 2.1-21 MPa and temperatures from …
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Biodegradable polyanhydrides as drug delivery systems
… of the anhydride bonds resulting in gradually polymer fragments collapse and release drugs in a controlled manner. In this study, two new biodegradable polyanhydrides copolymers were synthesised using a melt-polycondensation method. The first is poly (bis (p-carboxyphenoxy)-2-butene-co-sebacic …
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Core -Shell Microspheres for Biomedical Applications
… drugs and imaging agents. Core-shell protein or polymer microspheres are biocompatible vesicles that have been used to meet the goal of transporting drugs or contrast agents to diseased tissues via the circulatory system. They consist of a hydrophobic core surrounded by a protein or polymer …
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Synthesis of poly(NIPAM-co-vmbpy) microspheres and transition metal monomers for metallopolymeric material construction
… systems has garnered attention for PNIPAM-based polymer as potential biomedical materials. Candidate transition metal monomers containing ruthenium and nickel cores were designed and synthesized for copolymerization with NIPAM and cross-linker methylene-bis-acrylamide in order to attain …
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Microcapsule-based techniques for improving the safety of lithium-ion batteries
… is demonstrated by depositing thermoresponsive polymer microspheres onto battery anodes. When the internal temperature of the cell reaches a critical value, the microspheres melt and conformally coat the anode and/or separator with an ion insulating barrier, halting Li-ion transport and shutting …
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Investigation of protein destabilization in monodisperse poly(lactide-co-glycolide) microparticles
Poly(lactide-co-glycolide) (PLG) microspheres are a powerful choice for controlled release of protein therapeutics. However, several properties of PLG microspheres, particularly hydrophobicity and acidic microenvironment, may have detrimental effects on encapsulated protein, causing structural …