Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"polyinosinic:polycytidylic acid"”.
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Elevated temperature alters cytokine output and c-Jun N-terminal kinase signaling downstream of toll-like receptor activation
… following stimulation with lipopolysaccharide or polyinosinic:polycytidylic acid when U937 cells, a human monocyte cell line, are incubated at elevated temperature. The observed responses differ depending on the stimulus, suggesting that they are programmed responses to different stimuli rather …
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Comparative Analysis of Antiviral Responses in Mouse Embryonic Stem Cells and in Mesenchymal Stem Cells
… but not in ESCs, when they were exposed to polyinosinic:polycytidylic acid (poly(I:C), a dsRNA viral analog) and La Crosse Virus (LACV). Our results also showed that TLR3, RIG! and MDA5, the receptors for viral RNA, are expressed at lower levels in mouse ESCs (mESCs) than in C3H10Tl/2 cells. …
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Functional characterization of human and chicken TLR3
… then stimulated with the synthetic dsRNA analog polyinosinic:polycytidylic acid (poly I:C) to assess NF-κB signaling. These experiments allow us to evaluate how individual chTLR3 variants influence dsRNA sensing and signaling capacity. Understanding species-specific differences in TLR3 signaling …
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Anti-inflammatory Role of IL-15Rα Up-regulated by Poly I:C in Herpes Simplex Virus-induced Behcet's Disease-like Mouse Model
… CD8+ T cells. Recent studies informed that Polyinosinic:polycytidylic acid (Poly I:C) is an immunostimulant which boosts the generation of memory T cells though induction of IL-15 and IL-15Rα. We found that the frequencies of IL-15Rα were significantly lower in HSV-induced BD mouse model …
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Stat3 Inhibits Type I Interferon Signaling In Type I Conventional Dendritic Cells
… immunity. Herein, we show that IL-10 inhibits polyinosinic:polycytidylic acid (poly I:C)-induced cDC1 maturation in a STAT3-dependent manner. Transcriptome analyses further revealed that although poly I:C induces numerous inflammatory pathways in cDC1s, interferon (IFN) signaling was …
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Immunization with synthetic nanoparticles to generate mucosal CD8 T Cell responses
… (TLRa), monophosphoryl lipid A (MPLA) and Polyinosinic:polycytidylic acid (poly (I:C) or pIC) added to ICMVs as adjuvants. Pulmonary administration of ICMV with both adjuvants was found to give the most potent CD8 T cell response in both systemic and mucosal compartments. We looked further …
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Cellular responses to external threats probed by super-resolution microscopy
… the innate immune response starts from retinoic acid-inducible gene-I (RIG-I) protein which is a dsRNA sensor. For certain types of viruses, RIG-I localizes in cytoplasmic granular aggregates called as antiviral granules (AVGs). We infected/transfected cells by influenza virus lacking NS1 …
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Effects of mannan oligosaccharide on immune function and disease resistance in pigs
… did not affect AMφ-produced cytokines induced by polyinosinic:polycytidylic acid (Poly I:C). When applied in vitro, MOS suppressed LPS-induced TNF-α (P < 0.001), but enhanced LPS-induced IL-10 (P < 0.05). Further, TNF-α production by AMφ stimulated with LPS (P < 0.05) or Poly I:C (P < 0.001) was …
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Defining the clinical importance of epithelial-stroma-immune signalling in colorectal cancer using a molecular pathology approach
With current standard-of-care treatments, approximately 20% of stage II and 36% of stage III colon cancer (CC) patients will experience disease relapse following surgery. Molecular and histological subtyping of CC has identified a poor-prognostic group of patients characterised by high levels of …