Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"polygenic score"”.
-
Polygene Scores für häufige komplexe Erkrankungen und deren Anwendung auf Parkinson
… die derzeitigen Anwendung von polygenen Scores (PGS) auf häufige komplexe Erkrankungen in homogenen Populationen, insbesondere auf die Parkinson-Krankheit (PD, engl. Parkinson’s disease). Die fünf Hauptarbeiten dieser Dissertation setzen sich neben der Enwicklung von PGS vorallem mit …
-
Obesity and Health in the CHRIS study
… then on implementing and applying a Genome-Wide Polygenic Score for obese participants. These scores were computed for individuals based on the presence of different genetic variants weighted according to their measured effects in genome-wide association studies (GWAS). We then paid attention to …
-
Tempering the Ambition of Social Science Genomics: Causation, Explanation, and Evidence for Policy
… and related tools (particularly the so-called polygenic scores) within psychology, sociology, economics, and evidence-based social policy. I propose that the anticipated epistemic and non-epistemic payoffs from this type of integration can be understood in terms of two overarching promises or …
-
Proteomic Signatures of Type 2 Diabetes and Related Metabolic Traits
… T2D, of which the major driver was the T2D-polygenic score. However, individuals with HbA1c below the threshold for prediabetes but at high polygenic risk had a substantially lower cumulative T2D incidence than people with prediabetes. To investigate the predictive potential of plasma …
-
Risk Prediction and Value of Polygenic Risk Scores in Colorectal Cancer Screening
… are based on common genetic variants, known as Polygenic risk Score (PRS), have shown promises to guide personalized screening for colorectal cancer (CRC). Continuous efforts to improve PRS risk prediction are needed for clinical use, and understanding its added value of guiding CRC screening is …
-
Genetic and Environmental Influences on Cognitive and Neural Development
… generate meaningful and valid measures of polygenic propensity, and consider the ways the early environment and polygenic heritability influence and interact to influence specific features of the structural connectome, features that are essential for coherent neural communication and brain …
-
Modelling human complex traits with regression and neural-network based methods
Identifying how epistasis, non-linear genetic effects, contribute to phenotypic variance in humans has been an enduring challenge. So far neither the computational resources that could accommodate higher-order interactions at scale nor the large-scale population cohorts with adequate statistical …
-
Genetic and functional studies in inherited platelet disorders
… and inherited platelet disorders (IPDs). The polygenic score (PGS) for platelet count is constructed from 739 common variants, explaining almost 20% of phenotypic variance. The accurate determination of effect sizes of rare variants causal of IPDs is essential for reliable reporting of variant …
-
Common genetic variants contribute to risk of rare severe neurodevelopmental disorders
… affect only a small number of individuals. This polygenic burden in the DDD is also not confined to only patients who do not have diagnostic rare variants. Altogether, these results may have important implications for understanding variable clinical presentation of neurodevelopmental disorders …