Global ETD Search
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Showing 1 to 9 of 9 for “"polyene macrolide"”.
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Mechanisms underlying polyene macrolide mediated rescue of growth in ion channel deficient yeast
… ion pumps and transporters. AmB and other polyene macrolide ion channels are unregulated, unrectified, unselective, and passive. However, we hypothesized that through working together with H+-ATPases (drivers) and transporters (correctors) that imperfect small molecule ion channels are …
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Lewis Base Catalyzed Aldol Additions of Chiral Silyl Enol Ethers and Total Synthesis of Rk-397
… studies were applied in the total synthesis of polyene macrolide antibiotic RK-397. The synthesis features the highly site- and enantioselective vinylogous aldol addition using a chiral bisphosphoramide which allowed efficient construction of the key building block. The polyene fragment was …
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Comparative Study of Semisynthetic Derivative of Natamycin and the Parent Antibiotic on the Spoilage of Shredded Cheddar Cheese
The polyene macrolide antibiotic natamycin (Antibiotic A-5283) is commonly used to retard the growth of surface molds on various cheese varieties. Natamycin is commonly applied to the surface of cheese by dipping or spraying, using an aqueous dispersion containing 200 to 300 ppm of the additive. …
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Synthesis and function of the conserved motif of mycosamine-containing polyene macrolides
Mycosamine-containing polyene macrolides represent a large family of natural products with antifungal activity, of which amphotericin B (AmB) is an important member. Several of these clinically vital but toxic agents have been proposed to exert their biological activity through ion channel …
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Elucidation of the mycosamine dependent sterol binding and antifungal activities of amphotericin B
… deletion of functional groups from the macrolide skeleton followed by determination of the biological and biophysical consequences. The first functional groups we targeted for deletion were the carboxylic acid and the mycosamine sugar appendages. Both of these functional groups had been …
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Less toxic yet still resistance evasive amphotericins and atomistic probing of the amphotericin B ion channel
Amphotericin B (AmB) is a polyene macrolide natural product with two major functions: antifungal activity and ion channel formation. For over 50 years AmB has remained the last line of defense against systemic fungal infections. Remarkably, AmB has evaded the development of drug resistance during …
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Ensuring the Stability of Natamycin on Shredded Cheese
Natamycin is an antimycotic compound that is widely used in the cheese industry to increase the shelf life of cheeses, especially shredded cheeses, by inhibiting the growth of molds. Natamycin is applied to the surface of cheese as an aqueous suspension or as a powder. However, natamycin is not …
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Improved Properties of Natamycin Upon Formation of Cyclodextrin Inclusion Complexes
Natamycin is an antimycotic with very low water solubility and extremely high photosensitivity, which is used to extend the shelf life of shredded cheese products. The objectives of this research are: (a) to find a new delivery system for natamycin, which increases its aqueous solubility and (b) to …