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Showing 1 to 13 of 13 for “"polyelectrolyte complex"”.
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A novel polyelectrolyte complex between amphiphilic poly (allyl amine) and sodium alginate.
Polyelectrolytes are charge-carrying polymers. When two oppositely-charged polyelectrolytes are combined in a solution favouring charge expression, a polyelectrolyte complex can result. These complexes have been shown to be useful in the field of drug delivery in general. Amphiphilic …
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Chitosan-Cellulose Nanocrystal Polyelectrolyte Complex Particles: Preparation, Characterization, and In Vitro Drug Release Properties
Polyelectrolyte complexes (PECs) between chitosan, a mucoadhesive, intestinal mucosal permeability-enhancing polysaccharide, and cellulose nanocrystals, rod-like cellulose nanoparticles with sulfate groups on their surface, have potential applications in oral drug delivery. The purpose of this …
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Subcutaneous and oral delivery of insulin
… Insulin was found to be stable in a polyelectrolyte complex (PEC) consisting of insulin and LMWC in the presence of Tris-buffer at pH 6.5. In the presence of LMWC, the stability of insulin increased with decreasing molecular weight of LMWC; 13 kDa LMWC was the most efficient molecular …
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Multifunctional and Responsive Polyelectrolyte Nanostructures
<p>A polyelectrolyte complex is formed by mixing two oppositely charged polyelectrolytes in a solution. The electrostatic interactions between partially charged polymeric chains lead to the formation of a stable complex while avoiding the use of covalent cross linkers. Since complex formation can …
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A Bottom-Up Assembly Of Vascularized Bioartificial Constructs Using Ecm Based Microscale Modules
… that mimic the innate architecture and complexity of natural tissues. The limited ability to vascularize and perfuse thick, cell-laden tissue constructs has hindered efforts to engineer complex tissues and organs, including liver, heart and kidney. The emerging field of modular tissue …
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Controlling antibody delivery, mechanical properties, and cell response of alginate-chitosan polyelectrolyte complexes
… readily form ionic bonds in solution to form a polyelectrolyte complex (PEC). It was demonstrated that the release rate of non-specific IgG antibody could be tailored by altering the ratio of alginate to chitosan or the concentration of CaSO4 in the PEC, with the 50:50 alginate-chitosan PEC …
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Injectable chemokine-releasing gelatin matrices for enhancing endogenous regenerative responses in the injured rat brain
… We also synthesized dextran sulfate/chitosan polyelectrolyte complex nanoparticles (PCN), which could encapsulate SDF-1[alpha] efficiently and sustain its release for 4 weeks. When used in an in vitro migration assay to fill a core region that was surrounded by an aNPC-laden hydrogel …
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Polysaccharide-based nanostructures for growth factor delivery and mesenchymal stem cell activation
… were developed and characterized including polyelectrolyte multilayers (PEMs) and electrospun nanofibers. On flat gold-coated glass surfaces, PEMs were constructed using the polycations chitosan and N,N,N -trimethyl chitosan, and the polyanions hyaluronan, chondroitin sulfate, and heparin. …
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Production and Characterisation of Self-Crosslinked Chitosan-Carrageenan Polyelectrolyte Complexes
… toxicity in the body. Oppositely-charged polyelectrolytes (PEs) have the advantage that they can self-crosslink electrostatically and those derived from marine organisms are an inexpensive alternative to glycosaminoglycans present in the extracellular matrix of human tissues. A range of …
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Dual-Responsive Polymer and Hybrid Systems: Applications for Gene Delivery and Hydrogels
… also show excellent gene delivery. The inter-polyelectrolyte complex formation between the PDMAEMA corona of the core-shell-corona particles and pDNA showed that the pDNA molecules are individually complexed with single nanoparticles at N/P ratios (polymer nitrogen / pDNA phosphorous) where …
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Novel Biomimetic Polymeric Nanoconjugates as Drug Delivery Carriers for Poorly Soluble Drugs
… nanoconjugates based on the polymer-drug complexation in order to improve its physical and dissolution characteristics without the use of toxic organic solvents. Plain and ibuprofen-loaded binary and ternary nanoconjugates were prepared using four modified co-precipitation techniques …
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MRI and NMR Investigations of Transport in Soft Materials and Explorations of Electron-Nuclear Interactions for Liquid-State Dynamic Nuclear Polarization
… free polymer chain content in a polymer/DNA complex (polyplex) formulation via one-dimensional proton NMR experiments. This assessment of free polymer quantity has critical impacts on in vivo gene transfection efficiency, cellular uptake, as well as toxicity of polycationic gene delivery …
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Increased Utility of pH Sensitive Indicators as High Concentration CO2 Detectors Through the Use of Polyelectrolyte Complexes as Stabilizing Media
… Plastics made from large molecules known as polyelectrolytes can form complexes which may serve as inexpensive and multipurpose mediums for encapsulation of pH sensitive indicators. This research aims to combine the properties of both pH indicators and polyelectrolyte complexes (PECs) to form …