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Showing 1 to 20 of 37 for “"polydispersity index"”.
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Preparation and Characterization Of Oil-in-water Nano-emulsions Of Trifluoperazine For Parenteral Drug Delivery
… the Thin-layer hydration method. Z-average, polydispersity index, zeta potential of emulsions were determined. A fully randomized 2X2X2X2X2 statistical design was developed using JMP software. Optimal formulation was selected based on desirable properties of low z-average and polydispersity …
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Development and Characterization of Fluocinolone Acetonide Loaded Nanosized Lipid Carriers for Ocular Delivery via Subconjunctival Route: Synergistic Effect of Vitamin a Palmitate
… for physicochemical characteristics (size, polydispersity index and charge), release and stability studies. Further, in situ gel of FA-NLC was developed using gellan gum and hydroxypropyl methylcellulose as gelling agents. In situ gels were characterized for rheological behavior, in vitro …
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Synthesis and characterisation of vinyl block copolymers
… conclusive evidence of a living system and the polydispersity indices were between 1.5 and 3. However, using relatively apolar solvents, in the presence of aluminium alkyls, homopolymerisation of methyl methacrylate showed characteristics of a living polymerisation. An investigation of the …
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A Transferrin conjugated nanoemulsion system for brain delivery of antiretroviral therapy
… into Tf-NE as an antiretroviral agent. Size, polydispersity index, and dispersion stability were characterized using dynamic light scattering (DLS) system. Morphology of the Tf-NE was investigated using transmission electron microscopy (TEM). Differential scanning calorimetry was performed to …
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Topical Clear Aqueous Nanomicellar Formulations for Age-Related Macular Degeneration
… critical micellar concentration (CMC), polydispersity index (PDI), zeta potential and delineate the effect of drug-polymer interactions. The formulation will be administered in the form of topical eye drops.
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The impact of variation in freezing and thawing process parameters on the critical quality attributes of a monoclonal antibody
… with only a significant change noted for the polydispersity index (PdI), as measured by dynamic light scattering (DLS).
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Development of a novel 3-fluid nozzle for spray-dried microencapsulation of quercetin in zein and sodium caseinate
… effect (p < 0.05) on resultant particle size and polydispersity index (PDI). Quercetin was successfully encapsulated in a zein/sodium caseinate system using spray drying with the novel 3-fluid nozzle. Contact time between the two phases for encapsulation was varied but found to have no significant …
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Solution properties and molecular size of polyhydroxybutyrate from recombinant Escherichia coli
… average PHB molecular weight dropped and the polydispersity index sharply increased due to an immediate increase in the number of short chains produced.
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Bioproduction Optimization and Characterization of Hyaluronic Acid in Escherichia coli and Nicotiana benthamiana
… low molecular weights (2.3–3.6 kDa) and narrow polydispersity index, indicating a highly uniform product compared to chemically degraded HA. Contrary to expectations, co-expression of hyaluronidase did not further reduce polymer size, likely due to enzyme interference or substrate limitations at …
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Synthesis and Characterization of Drug-Containing, Polysaccharide-Based Nanoparticles for Applications in Oral Drug Delivery
… particle sizes were between 150-400 nm with polydispersity index values as low as 0.12. The antibiotic drug loading efficiencies ranged from 14-40%, whereas drug loading efficiency as high as 85 % was attained with the antiviral drug. The dissolution studies showed an increase in the solution …
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Development and Characterization of a Topical Ocular Delivery System for Hydrogen Sulfide for the Treatment of Glaucoma
… due to its gaseous nature and narrow therapeutic index. Therefore, this study developed a novel lipid-based delivery system for Diallyl Trisulfide (DATS), a H2S donor, to provide sustained release of H2S up to 8-9 hours upon topical application on the cornea. A high-performance liquid …
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Nanoemulsion formulations for brain tumour therapy
… paclitaxel the size increased to 294.6 nm. The Polydispersity Index (PDI) of all the nanoemulsion formulations (Clinoleic and Intralipid) were lower than 0.2 irrespective of paclitaxel concentration indicating that all nanoemulsion formulations used were homogenous. The pH values for the …
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An investigation of the biology and chemistry of the Chinese medicinal plant, Amorphophallus konjac
… with a weight average molecular weight (Mw), polydispersity index (PDI) and degree of acetylation (DA) of 9.5 ± 0.6 x 105 gmol-1, 1.2 and 2.8 wt. %. These data, plus Fourier-transform infrared spectral (FTIR) and zero shear viscosity analyses of the extract (PKF) were all consistent with the …
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Network morphologies in monodisperse and polydisperse multiblock terpolymers.
… were previously identified in “monodisperse” (polydispersity index (PDI) < ~1.1 in all blocks) poly(isoprene-bstyrene- b-ethylene oxide) (ISO) triblock terpolymers. This work extends the investigation of multiply continuous network structures to two other classes of multiblock terpolymers: i) …
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The use of non-ionic surfactant vesicles to prevent radiocontrast media-associated damage
… physical characteristics including size, polydispersity index (PDI) and particle distribution. Phase analysis light scattering was used to measure surface charge. NIVs were purified using ultracentrifugation prior to the quantification of IOX encapsulation efficiency and release using high …
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Development of Aerosolizable mRNA Incorporated Chitosan Nanoparticles for Efficient Lung Delivery
… for their particle size, zeta potential, polydispersity index, and encapsulation efficiencies. The blank and mRNA-incorporated nanoparticles had an average particle size of 150nm and 212nm with 1.5 and 16.38 mv of zeta potential, followed by a poly dispersity index of 0.1 and 0.3. The …
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NANOFORMULATION OF BUDDLEJA DAVIDII EXTRACT: DEVELOPMENT AND CHARACTERIZATION OF LIPOSOMES AND NANOFIBERS FOR WOUND HEALING APPLICATION
… were characterized in terms of vesicle size, polydispersity index, and zeta potential. Encapsulation efficiency and verbascoside release profiles were assessed by HPLC, while antioxidant activity was also evaluated. Formulation stability was monitored for two months, and in vitro …
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Nanocápsulas furtivas de óleo de copaíba contendo anfotericina B: um sistema promissor no tratamento de infecções fúngicas sistêmicas
… NF1 had a particle mean size of 255.1 ± 1.1 nm, polydispersity index (PdI) of 0.144 ± 0.020 and zeta potential of - 27.6 ± 0.15 mV. NF2 system had a particle mean size of 342.6 ± 4.5 nm, PdI of 0.162 ± 0.022 and zeta potential of + 20.2 ± 0.68 mV. To optimize the NF2 system, an experimental …
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P-dimetilanilinazometinfenollerin oksidatif kondenzasyon polimerizasyonu
… (Mn), weight average molecular weight (Mw) and polydispersity index (PDI) of the synthesized polymers in aqueous alkaline and organic media. The molecular weight distributions of polymers were determined by gel permeation chromatography (GPC) method. Structures of synthesized Schiff bases and …
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Investigation of polymer grade blending in Ziegler-Natta Catalysed ethylene polymerisation systems
… product. The number average chain length and polydispersity index are adequate representatives of this distribution for reporting the properties of a polyethylene grade. For the purpose of applying optimal control theory, a polyethylene production process model was developed to calculate these …
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