Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"polycystin-1"”.
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The nanomechanics of polycystin-1: A kidney mechanosensor
Mutations in polycystin-1 (PC1) can cause Autosomal Dominant Polycystic Kidney Disease (ADPKD), which is a leading cause of renal failure. The available evidence suggests that PC1 acts as a mechanosensor, receiving signals from the primary cilia, neighboring cells, and extracellular matrix. PC1 is …
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The structural and functional characterisation of the PLAT domain of polycystin-1
Autosomal dominant polycystic kidney disease (ADPKD) is one of the commonest monogenic disorders of man, affecting approximately 1 in 1000 of the world’s population. It is characterised by the progressive development and expansion of renal cysts, which eventually replace the normal architecture of …
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The Role of Pkd1 in Mouse Inner Ear Hair Cells
… gene encodes a large transmembrane protein (polycystin-1 or PC-1) that is reported to function as a fluid flow-sensor in the kidney. As a member of the transient receptor potential (TRP) family, PC-1 has also been hypothesized to play a role in the elusive mechanoelectrical transduction (MET) …
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Dynamic Molecular Mechanisms and Drug Design of Important Therapeutic Targets
… helps promote HIV entry into host cells. Polycystin-1 (PC1) is an atypical GPCR with 11 transmembrane domains. Mutations in the PC1 protein are responsible for the majority cases of a potentially lethal human autosomal dominant polycystic kidney disease (ADPKD). Moreover, small …
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Leveraging cellular models of polycystic kidney disease for mechanistic discovery and therapeutic development
… mutations in PKD1 or PKD2 encoding the proteins polycystin-1 (PC1) and polycystin-2 (PC2), respectively. Despite significant advances in our understanding of the genes and proteins underlying PKD, there remains an unmet clinical need for optimized treatment in these patients. This has largely …
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ROLE OF THE Na,K-ATPase IN POLYCYSTIC KIDNEY DISEASE
… The Na,K-ATPase has been found to interact with polycystin-1, and we have found this to association to increase the sensitivity of the enzyme to ouabain. Our hypothesis is that due to their increased sensitivity to the hormone in ADPKD, the cystic renal epithelium is more susceptible to the …
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Na,K-ATPase signaling in cyst progression in autosomal dominant polycystic kidney disease
… in PKD1 or PKD2, genes which encode the proteins polycystin-1 and polycystin-2, respectively, cause ADPKD, it is not known how alterations of either these proteins lead to cyst development and growth. Further, the progression of ADPKD is highly variable, even among patients with the same mutation, …