Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"polyclonality"”.
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Polyclonal interactions in intestinal tumorigenesis
… transformed cell. This contrasts with reports of polyclonality in a number of neoplastic lesions. In the first part of this thesis, I combine multicolour lineage tracing with a mouse model of intestinal tumorigenesis to show that a significant proportion of tumours have a polyclonal origin …
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Tracing clonal cell plasticity in the microenvironment of pancreatic ductal adenocarcinoma
The pancreas may regenerate without stem cells by induction of cellular plasticity between differentiated cells. Although essential for the remarkable capacity for pancreas regeneration, this property entails a vulnerability to cancer through acinar-to-ductal metaplasia and dedifferentiation by …