Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"polycations"”.
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Exploring the cytotoxicity of polycations
… cytotoxic effect of a synthesized polycation and polycations coated with mPEG-tosylate are investigated. A three step synthesis was made and tested with multiple methods to confirm the occurrence of each step and the last step was tested for its cytotoxic effect. To coat a hyperbranched polyester …
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Investigation of microbicidal activity of surface-immobilized hydrophobic polycations
Hydrophobic polycations have been shown to completely kill bacterial, fungal, and viral pathogens, on-contact. Herein we describe advances with this technology on two fronts: (1) innovation of a polycationic-derivative that simplifies the labor-intensive covalent-immobilization procedure, and (2) …
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Influence on molecular geometry and chain conformation on properties of polyelectrolyte multilayers
… of LbLfilms composed of different weak polycations. Slight perturbations in film assembly conditions can lead to large differences in film properties. Polyion bacisity and architecture are less understood variables. The polycations used are of similar chemical composition but different …
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A study of polyelectrolyte complexes with dynamic light scattering
… formed from the reaction between polyanions and polycations (PE's) in polar solvents.
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Multifunctional bioreducible nanoparticles for gene therapy
… complexes of disulfide-containing polycations and nucleic acids) utilize the redox potential gradient existing between extracellular space and intracellular environment as a physiological stimulus to enhance delivery of therapeutic nucleic acids to the subcellular space. …
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Polyelectrolyte Complexes and their Therapeutic Potential
… cells in vitro by means of new star-shaped polycations was explored. Second, the structure of ionic multicompartment micelles (MCMs) when complexed with polyions was studied and the performance of these nanostructures as delivery agents of anti-cancer drugs both in vitro and in vivo was …
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Serum Stable Carbohydrate-Oligoethyleneamine Copolymers for Nucleic Acid Delivery
… backbone. Upon electrostatic complexation of the polycations and pDNA in aqueous media, nanosized particles were formed, and their sizes and zeta-potentials were characterized via dynamic light scattering (DLS). The glycopolymers were tested for pDNA binding, toxicity, cellular uptake, and …
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Structure-Property-Transfection Relationships in Polycation-mediated Non-viral DNA Delivery
… activity in vitro. Several families of polycations were synthesized in order to correlate chemo-physical characterization with transfection results. Results revealed that seemingly small changes in the structure of cationic polyelectrolytes can have profound consequences on their …
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The use of aminoglycoside antibiotic therapy in neutropaenic patients with haematological disease
… are amino sugars in glycosidic linkage and are polycations at physiological PH. The antibiotic effect is mediated through inhibition of protein synthesis and disruption of cell membrane integrity. Principal use is in treatment of Gram negative infection although aminoglycosides have activity …
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Characterization of Intermolecular Interactions in Nanostructured Materials
… thermodynamics of polyplex formation with polycations and DNA. The imidazolium-containing and trehalose-based polycations were both found to have endothermic, entropically driven binding with DNA, while the adenine-containing polycation exhibited exothermic DNA binding. In addition, ITC was …
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Modulatable endosomalytic, intracellularly biodegradable vectors for gene delivery
… be released once in the cytoplasm. The reducible polycations (RPCs) were synthesized from 2COPs. The sizes, surface charges and the stability of RPC polyplexes under the simulated physiological conditions extra- and intracellularly suggested that these RPCs are promising vectors. In addition, the …
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Transgenic manipulation of polyamine metabolism in poplar
<p>Polyamines are low molecular weight polycations found in all living organisms. They are involved in plant stress response and development. The study was aimed at analyzing the effects of altered polyamine metabolism on the polyamine and related pathways in transformed poplar cells overexpressing …
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Functionalized multilayer thin films for protection against acutely toxic agents
… versus several traditional synthetic polycations. The resulting coatings are mechanically stable and offer selective protection when the wearer is exposed to UV radiation (e.g.sunlight); whereas the inherent water transmissive nature of the multilayers allows for much greater water …
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Non-viral drug delivery systems for immune modulation
… Cationic lipids or lipidoids were promising polycations to apply to biodegradable particle surface-modification because they efficiently deliver siRNA. We screened 30 lipidoid formulations for optimal knockdown in P388-D1 macrophage cells, and isolated formulations that demonstrated up to 40% …
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Specific and efficient in vivo delivery of DNA and siRNA by polyethylenimine and its derivatives
… create PEI-gold nanoparticles (PEI-GNPs). These polycations were complexed with DNA and delivered topically to scratched rabbit cornea. PEI-GNPs effectively transfected corneal endothelium and evoked expression of the plasmid DNA without causing significant immunogenicity or toxicity. Finally, …
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Antizyme Inhibitor 2 : A Novel Regulator of Cellular Polyamine Homeostasis
Polyamines are organic polycations that participate in various physiological functions, including cell proliferation, differentiation and apoptosis. Cellular polyamines originate from endogenous biosynthesis and exogenous sources. Their subcellular pool is under strict control, achieved by …
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Antiviral polymeric drugs and surface coatings
… PEIbased (PEI = polyethylenimine) hydrophobic polycations against both enveloped and nonenveloped viruses. When solutions containing herpes simplex viruses (both 1 and 2) were brought in contact with NN-dodecyl,methyl-PEI coated on either polyethylene slides or latex condoms, they could be …
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Thermodynamics and kinetics of ion-exchange in perchlorate-selective poly(vinylbenzyltrialkylammonium chloride) matrices
… suggest the mechanical properties of hydrophobic polycations may be effectively controlled through judicious selection of fixed ion and counterion. The exchange of one counterion with another--perchlorate with chloride--induces mechanical stress in polycation matrices. The magnitude of the stress …
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Polysaccharide-based nanostructures for growth factor delivery and mesenchymal stem cell activation
… glass surfaces, PEMs were constructed using the polycations chitosan and N,N,N -trimethyl chitosan, and the polyanions hyaluronan, chondroitin sulfate, and heparin. An exhaustive spectroscopic study was performed on all of the PEMs pairs to investigate the effects of polyelectrolyte charge …
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Organic Self-Assembled Layer-by-Layer Thin Films for Second-Order Nonlinear Optics
… by fabricating films with several different polycations. While the specific interactions responsible for chromophore orientation in ISAM films remains unclear, hydrogen bonding and electrostatic effects are ruled out as the sole sources of orientation. The highest values of χ(2) were observed …
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