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Showing 1 to 19 of 19 for “"polyamidoamine"”.
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Synthesis and characterization of polyamidoamine dendrons
The main objective of this study is to synthesize Poly AMido AMine (PAMAM) dendrons using silica gel as support and characterize them. PAMAM dendron, a hyperbranch of the PAMAM dendrimer, was divergently synthesized on solid support. Prior to the propagation through (1) Michael addition of acryl …
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Design of folic acid, transferrin, and integrin receptor specific polyamidoamine dendrimers for gene delivery
Item withdrawn by Mark Zulauf (zulauf@illinois.edu) on 2012-06-14T15:37:18Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 2 Hwang_Mark.doc: 55420928 bytes, checksum: 0010b064d38a25a15d06deb51af67ca4 (MD5) Hwang_Mark.pdf: 22852276 bytes, checksum: …
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Self-assembly of linear-dendritic diblock copolymers
… weight linear polyethylene oxide (PEO) with a polyamidoamine (PAMAM) dendron covalently bonded to one chain end. Specular neutron reflectivity has been used to investigate the structure of monolayers formed at an air-water interface. The dendritic end groups were functionalized with deuterated …
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PREPARATION AND CHARACTERIZATION OF AN ELECTROSPUN GELATIN/DENDRIMER HYBRID NANOFIBER DRESSING
… degrade the reconstituted ECM. Starburst™ polyamidoamine (PAMAM) dendrimer G3.5, which provides a versatile and structurally controlled architecture to construct nanomedicine, was covalently bonded to the gelatin backbone and electrospun into nanofibers with gelatin, doxycycline and …
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Spectroscopic investigations of acrylodan dye interactions with poly(amidoamine) and poly(propyleneimine) dendrimers
… phenol blue, the first direct examination of the polyamidoamine (PAMAM) and polypropylenimine (PPI) dendrimer core cavities was reported by a previous research group member. This previous work revealed the need to further understand the sequestering abilities and host-guest properties of these …
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Dendrimer Modified Silica Nanoparticles as Fluorescent Chemosensors for the Detection of Copper and Cyanide Ions
… nanoparticles (SNP) were modified with branching polyamidoamine (PAMAM) dendrimers, which function as selective turn-off Cu<sup>2+ </sup>ion chelators and platforms for the attachment of rhodamine isothiocyanate (RITC) or fluorescein isothiocyanate (FITC) fluorescent dyes. In the presence of …
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Dendrimer Nanoconjugates And Their Oral Inhalation Formulations For Lung Cancer Therapy
… of drug to the lungs. In this work, we desgined polyamidoamine dendrimer (PAMAM) conjugates which can only release DOX intracellularly, while being stable in physiological environment. We observed the PAMAM-DOX conjugates upon local delivery to the lungs can significantly inhibit tumor growth …
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Molecular Modeling Studies of Dendrimers and Hyperbranched Polymers
… with the experimentally observed behavior of polyamidoamine (PAMAM) dendrimers, polypropylene imine (Astramol) dendrimers and the AB/AB2 polyetherimide (PEI) hyperbranched copolymers, in the dilute and entangled states.
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Study of Durability of Epoxy Bonded Joints in Aqueous Environments
… chosen as the epoxy resin, and dicyandiamide and polyamidoamine were two types of curing agent evaluated in this study. The epoxy bonded steels were exposed in either distilled water or 3.4% NaCl solution for various time periods. The mechanical strengths of the bonded joints were evaluated using …
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Genomic and Non-Genomic Actions of Estrogen Receptor Ligands
… conjugates are large, abiotic, non-degradable polyamidoamine (PAMAM) dendrimer macromolecules that are conjugated to multiple estrogen molecules through chemically robust linkages. Because of their charge and size, these estrogen-dendrimer conjugates (EDCs) remain outside the nucleus. They …
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Immobilized liquid membranes for facilitated transport and gas separation
… concept of forming ILMs was demonstrated with Polyamidoamine (PAMAM) dendrimer as the liquid membrane in its pure form. The pure dendrimer ILMs studied in the present thesis functioned as C02-selective molecular-gate membranes. It was also demonstrated that a judicious use of glycerol as a …
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Effect of combinations of drugs on glioma chemotherapy
… effect of conjugation of novel generation 3 (03) polyamidoamine (PAMAM) dendrimer to chemotherapeutic agent, Paclitaxel. The cytotoxicity results showed that paclitaxel, when conjugated to the 03 PAMAM dendrimer, was significantly more toxic then when used alone. P-glycoprotein (Pgp) is the major …
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The Development of a Novel Tumor -Specific MRI Contrast Agent Targeting the High Affinity Folate Receptor: In Vitro and in Vivo Specificity, Toxicity, and Biodistribution
… essential. Here, we present a generation four polyamidoamine (PAMAM) dendrimer conjugated to folic acid that specifically targets the high affinity folate receptor (hFR) overexpressed on more than 80% of ovarian tumors. We tested the hypothesis that folate-dendrimers can specifically image …
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Spectroscopic investigations of dendritic polymers as molecular containers
… dendritic polymers polypropyleneimine (PPI) and polyamidoamine (PAMAM). The phenol blue will associate with the core of the dendrimer molecules. This association revealed previously unknown information about the microenvironment of the dendrimer interior, including accessibility, size, and …
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PREPARATION OF NANO- AND MOLECULAR COMPOUNDS FOR ANTITUMORAL APPLICATIONS TRIGGERED BY LIGHT
… gold nanostars (GNS) was functionalized with a polyamidoamine-Ru(II) complex to increase the PDT efficiency of the complex, i.e. to produce ROS upon irradiation, due to the metal-enhanced 1O2 generation promoted by GNS. Another possible advantage of such functionalized nanostructures that has …
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Polyphosphate is a novel modulator of coagulation and inflammation and is a therapeutic target
… substances such as polyethylenimine, polyamidoamine (PAMAM) dendrimers and polymyxin B, while attenuating thrombosis, all had significant toxicity in vivo, likely due to the presence of multiple primary amines responsible for their polyP binding ability. In collaboration with the …
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Effect of uptake pathway on non-viral gene delivery in vitro and in vivo
… to in vitro polyethylenimine (PEI)- and polyamidoamine (PAMAM)-mediated gene delivery in HeLa cells through the use of small molecule drugs and small-interfering RNA [1-2]. The goal of this thesis is to further elucidate the effects of cellular uptake mechanism on non-viral gene delivery …
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An Investigation of The Use of Dendrimer-Based Carrier to Cross Cellular Barrier
… This study investigated the ability of polyamidoamine (PAMAM) dendrimer-based drug delivery systems to enhance the permeability of a drug that is a substrate of P-glycoprotein (P-gp) efflux transporter with low water solubility. This thesis described the syntheses, characterisations and …
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BIOINSPIRED POLYAMIDOAMINES AS INNOVATIVE FLAME RETARDANTS FOR CELLULOSIC FABRICS
… attention and efforts onto 5 research lines: 1. Polyamidoamines derived from natural a-amino acids as effective flame retardants for cotton fabrics; 2. Study of the polyamidoamine decomposition products upon heating; 3. Phosphorous-sulphur-based polyamidoamines as flame retardants for cotton …