Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"polyacrylamide hydrogel"”.
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Polyacrylamide hydrogel friction controlled by time-dependent surface energy due to poroelastic relaxation
… contact area, contact time, and sliding speed of polyacrylamide hydrogel. With a comprehensive understanding of the phenomenon, hydrogels could be designed with targeted friction behavior, and be used to design surfaces for tissue engineering and drug delivery. Polyacrylamide gels were tested to …
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Functional Microperiodic Polyacrylamide Gels Fabricated by Opal Inversion and Direct-Write Processes
Functional three-dimensional microperiodic polyacrylamide hydrogel structures were created and characterized. Submicron to 50 micron periodicities were explored across the structures, the lower end for optical and filtration potential and the larger for cell growth scaffolds. Two synthesis methods …
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Engineering tough, hygroscopic, and active hydrogels for surgical simulation and anti-biofouling
Hydrogels have emerged as a class of materials useful for a variety of contexts, including tissue engineering, anti-fouling, drug release, medical devices, and flexible electronics. The usefulness of hydrogels in these contexts stems from their structure, consisting of a 3D cross-linked polymer …
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A dressing solution for burn wounds: antibacterial and low-adherent wound dressings
… a problem. In this study, low-adherent PAM (polyacrylamide) hydrogel incorporated with less toxic AgNP (silver nanoparticle), was immobilized onto PET (poly(ethylene terephthalate)) substrates by an IPN (interpenetrating polymer network) method. The modified PET is effectively antibacterial …
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Role Of Substrate Stiffness In Driving Atherogenic Behavior In Macrophages.
… to atherosclerosis plaque formation using a polyacrylamide hydrogel-based in vitro model of atherosclerotic tissue.
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Bioanalytical applications of microfluidic devices
… printed in high fidelity on a receptor modified polyacrylamide hydrogel substrate. The patterns obtained can be controlled through modifications of channel design and secondary programming via selective membrane wetting. The protocols support the printing of multiple reagents without registration …
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Modeling and Optimization of Tunable Insulated Hybrid Cooling to Extend Food Shelf-life Using Scalable and Affordable Materials
… porous membrane for radiative cooling, polyacrylamide hydrogel for evaporative cooling, and aluminum sheet as a substrate. Instead of the state-of-art radiative cooling material that requires complex and expensive fabrication, TIHC leverages commercially mass-produced hydrophobic porous …
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Biomaterials for the extracellular control of mesenchymal stem cell pro-angiogenic potential
… a short introduction we explore using model polyacrylamide hydrogel systems in Chapter 2 to study the effects of matrix elasticity and composition on MSC pro-angiogenic potential, showing elasticity can play a large role – dependent on matrix composition. In Chapter 3 we use micropatterning …
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Hydrogels for Biomacromolecule Immobilization and Sensing
… centers on the development of stimuli-responsive hydrogels that have utility for pH-responsive valves, biomacromolecule sensing, irreversible biomacromolecule immobilization, and reversible biomacromolecule immobilization. Each system discussed has its function derived from a novel fabrication …
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Engineered biomaterials as extracellular microenvironments for guiding cell programming and reprogramming
… a short introduction we explore using model polyacrylamide hydrogel systems in Chapter 2-5 to study the effects of biophysical (elasticity and geometry) and chemical (matrix protein) cues on mesenchymal stem cell (MSC) fate decisions, showing these cues can play a large role in …
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Electrochemical Synthesis of Silver Nanoparticles for Applications in Nitrate Detection, Catalysis and Antibacterial Activity
… nanoparticles were successfully immobilised in a polyacrylamide hydrogel and employed in the reduction of 4-nitrophenol in the presence of NaBH4. The 4-nitrophenol was completely reduced after a 60 min period with a first order rate constant of 7.4 x 10-4 s-1. The activity of the hydrogel …
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Stiffness controls primary cilia position and length: mechanisms and potential in reversing osteoarthritis phenotypes
… based on substrate stiffness alone. A polyacrylamide hydrogel system of varying substrate stiffness was used to examine the role of substrate stiffness on cilia frequency, length and centriole position as well as cell and nuclei area over time in mouse articular chondrocytes. Contrary …
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Wear mechanisms of chemically crosslinked hydrogels under mild abrasion
The structural and mechanical resemblance of hydrogels to cartilage makes them promising candidates for cartilage replacement in load bearing joints. These biphasic materials are composed of an elastic network that retains a large volume of water allowing them to efficiently maintain smooth sliding …
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Control of surface structure and properties of responsive hydrogel interfaces via electrostatic interactions
Hydrogels are primary candidates for applications in soft robotics, biomedical devices, and tissue engineering due to their biocompatibility, extremely low coefficients of friction, and potential for a variety of responsive behaviors.[1] Their biphasic nature and viscoelastic network results in a …
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Functional gel for directed molecular transport and sensor applications
… a micrometer scale radial chemical gradient in a polyacrylamide hydrogel. Collaborating with Spencer Joseph Kieffer in prof. Alleyne group, we discovered that by downscaling the chemical gradient from a few millimeters to 100s of micrometers, the analyte collection capability was enhanced. A …
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Modeling interactions between cells and the aqueous environment
… study, the cell membrane model consists of a hydrogel-supported lipid-bilayer. Hydrogels are cross-linked polymer networks that can absorb large amounts of water without dissolving or loosing their shape. A number of hydrogels are stimuli-sensitive. They can change their structures and …
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Fabrication and characterization of co-continuous elastomer-hydrogel composites
… research, a co-continuous structured elastomer-hydrogel composite is fabricated to combine the elasticity of elastomer and the permeability of hydrogel. The stretchable, water permeable composite can be used as a mechanically tunable molecular sieve in drug delivery and tissue engineering. …
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Synthesis and kinetic processes in designed polymers
… the confinement effect of the cross-linked hydrogel and reveal the effect of noncovalent interactions of the protein with the polymer surface. Additionally, we demonstrate that a biomedically-relevant zwitterionic polymer in solution can interact with proteins directly through utilizing …
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Dissecting combinatorial microenvironmental regulation of cell fate and function using a multi-modal arraying platform
Engineered systems provide a means of deconstructing the microenvironmental cues which guide cell fate and function. These cues can include biochemical elements, as in ligand–receptor binding for cell–cell or cell–extracellular matrix (ECM) interactions, or responses to biophysical parameters, as …