Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"poly-glutamine"”.
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Quantitative analysis of proteotoxicity associated with neurodegenerative disease
… I combined modeling of the proteotoxicity of polyglutamine (as exemplified in Huntington's Disease) in Saccharomyces cerevisiae with microfluidics and automated microscopy. From these studies, I have found that glutamine-rich proteins suppress the toxicity of poly-glutamine expanded Huntingtin …
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Polyglutamine monomer structure and its implications for molecular self-assembly
Polyglutamine is a naturally occurring peptide found within several proteins in neuronal cells of the brain, and its aggregation has been implicated in several neurodegenerative diseases, including Huntington's disease. The resulting aggregates have been demonstrated to possess ~-sheet structure, …
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Unveiling the Intercompartmental Signaling Axis: Mitochondrial to ER Stress Response (MERSR) and Its Impact on Proteostasis
… proteostasis load. MERSR activation in both poly-glutamine (poly-Q) and amyloid-beta (Aß) C. elegans disease models also leads to improvement in both aggregate burden and overall disease outcome. These findings shed light on the coordination between the mitochondria and the ER in maintaining …
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Modulation of Huntington's disease-associated phenotypes by the striatal-enriched transcription factor Foxp2
… in the huntingtin (HTT) gene, which encodes a poly-glutamine (polyQ) repeat protein. Despite widespread expression of the HTT gene, HD presents with massive neuronal cell loss and transcriptional dysregulation primarily in the striatum and deep layers of the cortex. Synaptic dysfunction and …
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Cell attachment to Zein surfaces
… It is a prolamin containing multiple poly-glutamine strands. Previous studies suggested that glutamine residues on zein structure are involved in NIH 3T3 cell adhesion. Considering that tTG mediates cell adhesion mainly through crosslinking between glutamine residues and lysine …
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INVESTIGATING THE IMMEDIATE CONSEQUENCES OF NORMAL AND MUTANT HTT LOSS IN HD-HESC THROUGH THE DTAG SYSTEM.
… by a dominant CAG triplet repeat expansion (poly-glutamine(Q) in the protein) in the first exon of the Huntingtin gene (HTT). In the healthy population, the number of CAG repeats range between 9 and 35, while an expansion above 36 CAG repeats causes the manifestation of the pathology later in …
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Modelling of colloidal dynamics in complex soft matter systems
… entry and exit of radicals during an emulsion polymerization. The second part of the thesis is then dedicated to the development of a mathematical model which, by using the pseudo-homopolymerization approach, describes the kinetics of this polymerization mode. By using the state-of-the-art …
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Novel extracellular products of Mycobacterium tuberculosis: composition, synthesis, and relevance to disease
… the biochemical pathway involved in α-L-polyGlutamine (α-L-polyGln) biosynthesis and determining its role in pathogenesis in the murine model of TB. α-L-polyGln is an Mtband Mycobacterium bovis (M. bovis) specific product and its presence in virulent Mycobacterium spp., …
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COMPOSTI AD AZIONE ANTI-AGGREGANTE ESERCITANO UN EFFETTO BENEFICO SU MODELLI CELLULARI DI ATROFIA MUSCOLARE SPINALE BULBARE
… expansion of the CAG repeat, encoding for the poly-glutamine tract (polyGln), in the N-terminal region of the Androgen Receptor (AR) gene. This mutation leads the protein to form intranuclear aggregates in the spinal cord and brainstem and cause the death of those specific cell populations. AR …