Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 44 for “"poly(lactide)"”.
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Investigation of protein destabilization in monodisperse poly(lactide-co-glycolide) microparticles
Poly(lactide-co-glycolide) (PLG) microspheres are a powerful choice for controlled release of protein therapeutics. However, several properties of PLG microspheres, particularly hydrophobicity and acidic microenvironment, may have detrimental effects on encapsulated protein, causing structural …
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Synthesis and Characterization of Poly(lactide) Functional Oligomers and Block Copolymers
Amphiphilic block copolymers consisting of poly(ethylene oxide) and poly(lactide) have great potential for formulating drug delivery systems. Our approach was to synthesize poly(ethylene oxide-b-D,L-lactide), (PEO-b-PDLLA), block copolymers with controlled molecular weights and good functionality …
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Amphiphilic Poly(2-isopropyl-2-oxazoline)-block-poly(lactide) Nanoparticles as Drug Delivery Vehicles
… of the unique morphologies of water-soluble poly(2-isopropyl-2-oxazoline)-block-poly(DL-lactide) and poly(2-isopropyl-2-oxazoline)-block-poly(L-lactide) (PiPOx-b-PDLLA and PiPOx-b-PLLA) nanoparticles was obtained via Fluorescence Spectroscopy. Additionally, loading and release studies were …
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Synthesis and Characterization of Injectable Star-shaped Poly(Lactide-co-Glycolide-co-Acrylate) Macromers
<p>Polymers, as hydrogel macromers, have been studied and widely applied to develop scaffolds in tissue engineering since 1990s, because they offer a number of advantages over other materials such as the ability to tailor mechanical properties and degradation kinetics based on various applications. …
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Studies towards degradable polymers new zinc (II) and palladium (II) complexes as catalysts for lactide polymerization and carbon monoxide
… and used in the production of degradable polymers. Zinc complexes were used for the production of polylactides (PLAs) functionalized with a drug candidate on a polymer tail. These functionalized polymers displayed slow drug release properties under physiological conditions. Palladium …
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Characterization of Everolimus In Biodegradable PLAF/PLEOF Nanoparticle
… vessels. Therefore, biodegradable core-shell polymeric nanoparticle (NP), with a hydrophobic core and hydrophilic shell was developed for surfactant-free encapsulation and delivery of Everolimus from DES. Elution of Everolimus was measured from Poly (lactide-fumarate)(PLAF) and Poly …
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Biophysical characterization of hydrogel-core, lipid-shell nanoparticles (nanolipogels) for HIV chemoprophylaxis
… capabilities to encapsulated cargo. Polymeric nanoparticles made from poly(lactide-co-glycolide) (PLGA) are biodegradable, exhibit tunable drug release, and have encapsulated a wide variety of biological agents. However, PLGA nanoparticles are relatively inefficient at encapsulating …
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Co-encapsulation of anti-breast cancer drugs in nanoparticles reduce antagonism
… that after the co-delivery of DCL and TAM in poly (lactide)-D-a-tocopheryl polyethylene glycol succinate nanoparticles (PLA-TPGS NPs), drug antagonism was significantly reduced versus its free unprotected form, and this effect attenuated at high drug concentrations. The fluorescent model drug …
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Fabrication of hydroxyapatite-biodegradable polymer scaffolds by electrospinning for potential bone tissue application
… potential of combining hydroxyapatite (HA) and polymers to form synthetic composite materials used for bone tissue engineering applications. In this study, ceramic-biodegradable polymer composites are fabricated by electrospinning method. The biodegradable polymers used are poly(L-lactic acid) …
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Chitosan and PLGA microspheres as drug delivery system against pulmonary mycobacteria infections
… for their stability during nebulization. Poly(lactide-co-glycolide) (PLGA), chitosan (CHT) and PLGA/CHT microparticles (MPs) were prepared by emulsion, precipitation or spray-drying techniques. MPs ability to be nebulized (NE%) as well as stability during freeze-drying or/and nebulization …
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Uniform double wall microspheres/microcapsules for protein delivery
Biodegradable polymer devices have been utilized as a means to deliver drugs in a controlled and less invasive manner. Poly (lactide-co-glycolide) (PLG) and poly (lactic acid) (PLA) microparticles such as double-wall/single-wall microspheres and microcapsules were heavily investigated for …
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Development of P(TMC)-Based Polymers for Sustained Delivery of Acid-Sensitive Drugs
… is to load the peptide into a biodegradable polymer which is then injected close to the drug’s site of action. The polymer provides extended drug release, before degrading and being removed by the body. This is done commercially by a polymer called poly(lactide-co-glycolide), or PLG. However, …
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Development of a Novel Vaccine Adjuvant System Utilizing an In Situ Implant System to Modified Release
… N-Methyl-2-Pyrrolidone, NMP) and hydrophobic polymer (e.g. poly (lactide-co-glycolide), PLGA). We have given this concept the name of AdjuGel to distinguish it from simple drug administration. It was developed by incorporating an oil (e.g. Acetyl Tributyl Citrate, ATBC) into an ISI system. …
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Controlled release in inhalation
… chapter introduces the biocompatible polymer chitosan (mw 190 – 310 kDa) to formulations containing leucine with findings of increased FPF with increasing leucine concentration (up to 82%) and the prolonged release of the active markers terbulataline sulfate (up to 2 hours) and …
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Drug Delivery to Solid Tumors via Polymeric Nanoparticles
… of NPs is avoided by coating NP surface with Polyethylene glycol (PEG). Although successful in prolonging NPs circulation, PEG prevents proper interaction of NPs with the target cells, known as “PEG dilemma”. Low molecular weight chitosan (LMWC) can function as a hydrophilic pH-sensitive …
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Microneedle delivery for improved efficacy of antiretroviral and antibiotic drugs
… in the organic phase of biodegradable poly(lactide-co-glycolide) microparticles (MP) synthesized through a double emulsion. Similarly, Ciprofloxacin was encapsulated in the aqueous phase of the microparticles. In addition, Ciprofloxacin microcrystals were synthesized. The microparticles …
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Polyelectrolyte multilayers (PEM) in micro / nanofluidics for novel BioMEMS platforms
… thesis was to exploit the versatility of the polyelectrolyte multilayer (PEM) to fabricate a novel micro/nanofluidic device for patterning bacteria in BioMEMS. Nanofluidic channels offer new opportunities for advanced biomolecule manipulation and separation science because they provide unique …
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The sustained delivery of antisense oligodeoxynucleotides using biodegradable polymer microspheres
… reduce dose required for efficacy. Biodegradable polymer microspheres were evaluated as delivery devices for ODNs and ribozymes. Poly(lactide-co-glycolide) polymers were used due to their biocompatibility and non toxic degradation products. Microspheres were prepared using a double …
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The Dynamics of Phase Separation and Structure Formation in Phase Inversion
… are presented, the process by which a cast polymer solution is converted into a porous, polymer gel by either thermal or nonsolvent quenching. In all three of the studies presented in this thesis, in-situ optical techniques have been used to study the dynamics of phase separation and …
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