Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 59 for “"poly(lactic-co-glycolic acid)"”.
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Bioactive Poly(Lactic-co-Glycolic Acid)-Calcium Phosphate Scaffolds for Bone Tissue Regeneration
Bone is currently the second most transplanted tissue, second only to blood. However, significant hurdles including graft supply and implant failure continue to plague researchers and clinicians. Currently, standard clinical procedures include autologous and allogeneic grafting. Autologous grafts …
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Designing and characterizing the plant-based chitosan-modified poly (lactic-co-glycolic acid) nanoparticles for salmonella and e. coli-induced gastroenteritis
… in 2020. Salmonella species and Escherichia coli were responsible for most bacterial gastroenteritis cases reported in Windhoek in 2018. Some of the key challenges in the management of gastroenteritis are: 1) Antibiotics and antidiarrheal agents used in the treatment of gastroenteritis have …
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Preparation and characterization of poly lactic-co-glycolic nanoparticles encapsulated with gentamicin for drug delivery applications
… shown to be a potentially effective approach to control bacterial infections at a wound position. Recently, biodegradable and biocompatible polymers have drawn lots of attention for the manufacture of drug-loaded nanoparticles in the pharmaceutical industry. In this work, poly-lactic-co-glycolic …
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3D Printing Of A Biocompatible Scaffold And A Real-Time Imaging Window For Monitoring Rat Spinal Cord Regeneration
… of effective regenerative therapies for spinal cord injury (SCI) remains limited by two critical challenges: the absence of structurally optimized bridging scaffolds and the inability to monitor biological integration in real time. Conventional experimental approaches rely primarily on endpoint …
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Poly ([beta]-amino ester)s as pH sensitive biomaterials for microparticulate genetic vaccine delivery
… vaccination is the administration of nucleic acids to induce cellular expression of antigens, leading to an immune response. Unlike traditional vaccines, this technology has tremendous potential for treating or preventing diseases such as HIV, malaria, and cancer. However, this potential is …
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Developing Low Fouling Peptides and Zwitterionic Materials for Biomedical Applications
This dissertation is a compilation of efforts aimed at developing mixed charge and zwitterionic materials to prevent biofouling in biomedical applications. Peptides are considered for use as natural low fouling materials due to their biocompatibility, diverse chemical properties, well-defined …
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A Novel Technique for Fabricating Aligned Nanofibers by Using Solution Electrospinning
… placed in the system, aligned nanofibers were collected on the grounded aluminum collector which was located between two wheels. Polymer solutions were pumped to the system at 1.0 ml/h. As polymer, poly(lactic-co-glycolic acid) (PLGA 50/50) was dissolved in hexafluoro-2-propanol (TCI). …
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Polyelectrolyte multilayers for tunable release of antibiotics and other therapeutics
Polyelectrolyte multilayers (PEMs) were fabricated via the layer-by-layer (LbL) deposition process, incorporating hydrolytically degradable poly([beta]-amino esters) to result in biodegradable PEMs that can release active ingredients in a dosage- and rate-tunable fashion. Specifically, PEMs …
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Evaluation of Non-functionalized Single Walled Carbon Nanotubes Composites for Bone Tissue Engineering
… tumor resection, pathological degeneration, or congenital deformity pose a great challenge in the field of orthopedics. Traditionally, these defects have been repaired by using autografts and allografts. Autografts have set the gold standard for clinical bone repair because of their …
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Development of nanoparticle based nicotine vaccines for smoking cessation
Cigarette smoking is prevalent worldwide and has consistently been the top preventable cause of many serious diseases., which result in huge mortality, morbidity, and economic loss, in recent decades. In recent years, nicotine vaccines that can induce production of nicotine specific antibodies in …
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Stability of proteins within biodegradable microspheres
In the past decade, biodegradable polymers have become the materials of choice for a variety of biomaterials applications. In particular, poly(lactic-co-glycolic acid) (PLGA) microspheres have been extensively studied for controlled-release protein delivery. However, significant issues arise in …
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Induction of Immunogenic Cell Death via Nanoparticle-Mediated Dual Chemotherapy and Photothermal Therapy
Cancer is the second most common cause of mortality in the world. Several treatment modalities have been developed for cancer therapy. Recently, immune checkpoint (ICP) therapy has demonstrated promising results. However, low response rates, cancer recurrence and side effects are remaining …
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Composite gelatin delivery system for bone regeneration
… the chemical/mechanical properties and biocompatibility of gelatin were investigated to produce a gelatin scaffold for the release of bone morphogenetic proteins (BMPs) from composite particles. This delivery system, designed to regenerate bone, holds much promise as an alternative to bone …
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Nanoparticle-Based Drug Delivery and the Impacts on Cancer Cell Biophysical Markers
… and physiological changes within the cells are accompanied by alterations in the biophysical properties. Therefore, the cell biophysical properties can serve as promising markers for cancer detection and physiological activities. To aid in the investigation of the biophysical markers of cells, a …
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Prospective Clinical Study with New Materials for Tissue Regeneration: A Study in Humans
… clinical, radiographic, and histomorphometric outcomes of novel bone grafting materials and dental membranes and to compare the results with current data from literature. Materials and Methods: New synthetic bone substitutes, consisting of biphasic calcium phosphate, in the ratio of 60% …
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Bacteria-Enabled Autonomous Drug Delivery Systems: Development, Characterization of Intratumoral Transport and Modeling
… of the drug to all tumor cells in sufficient concentrations. Intratumoral drug transport is limited by characteristics of the tumor microenvironment such as elevated interstitial pressure and sparse, irregular vascularization. Moreover, poor tumor selectivity, leads to systemic toxicity. …
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Biomaterials for tissue engineering for rheumatoid arthritis based on controlling dendritic cell phenotype
The host response toward biomaterial component of tissue-engineered devices has been extensively investigated. The objective of this research was to understand the response of dendritic cells (DCs) to different biomaterials upon contact and identify biomaterials suitable for use in tissue …
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A study of bioprocess designs for development of the myogenic secretome as a source of bioactive extracellular vesicles
… of this study is to investigate approaches that could support manufacture of a bioactive human skeletal myoblast secretome at therapeutically relevant yields. An upstream process for myogenic secreted EVs and proteins was optimised over 7-days. Analytics involved quantification of secretome yield …
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A Novel Biostable 3D Porous Collagen Scaffold for Implantable Biosensor
… the body loses its ability to maintain normal glucose levels. Despite of development of implantable glucose sensors in long periods, none of the biosensors are capable of continuously monitoring glucose levels during long-term implantation reliably. Progressive loss of sensor function occurs due …
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