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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"poly(l-lactide)"”.
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Functional Self-Assembled Poly (L-Lactide) Nanoparticles For Targeted Delivery of Bioactive Agents
… in cancer therapy.</p> <p>In the first part, poly(lactide-co-glycolide) fumarate (PLGF) NPs were used for the delivery of recombinant human bone morphogenetic protein-2 (rhBMP-2) and a peptide isolated from the BMP-2 protein. They were encapsulated in or grafted to the NPs for their sustained …
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Fundamental Studies of Various Poly(L-lactide)/clay Nanocomposite Systems by in-situ Polymerization
… on the environment. In order for biodegradable polymers to successfully compete with commodity polymers, mechanical, thermal, and gas barrier properties must be improved. This can be achieved by dispersing inorganic fillers into the polymer matrix, thus forming an exfoliated polymer …
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The Degradation and Drug Release Mechanisms of Poly(ethylene glycol)-functionalised Poly(L-lactide) Polymers
Poly(L-lactide) (PLLA) is a well-recognised bioresorbable polymer known to degrade after 1.5 to 5 years by hydrolysis. For certain medical device or drug delivery applications, it would be desirable to reduce this degradation time as strategies for tailoring degradation and drug release rates …
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Synthesis and Characterization of Polylactide-siloxane Block Copolymers as Magnetite Nanoparticle Dispersion Stabilizers
Polylactide-siloxane triblock copolymers with pendent carboxylic acid functional groups have been designed and synthesized for study as magnetite nanoparticle dispersion stabilizers. Magnetic nanoparticles are of interest in a variety of biomedical applications, including magnetic field-directed …
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Interactions between adult human mesenchymal stem cells and nanofibrous scaffolds of different compositions
… extracellular matrix. One is derived solely from Poly-L-lactide acid and the other from Poly-L-lactide/Gelatin (50:50). Before and after culturing, measurements of fiber diameter, thermodynamics, and tensile strength were collected. Studies with primary human MSCs were conducted to characterize …
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Fabrication of nanofiber scaffolds by electrospinning and it's potential for tissue engineering
… an electric field to control the deposition of polymer fibers on to a target substrate. This electrospinning strategy can be used to fabricate fibrous polymer mats composed of fiber diameters ranging from several microns down to tens of nanometers. This study assesses the potential of …
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The Use of Resorabable Plates for the Fixation of Mandubular Fractures
… fractures with biodegradable self-reinforced poly-L-lactide(SR-PLLA) plates and screws. Metallic bone plates and screws have been commonly used in oral and maxillofacial surgery for internal fixation. However, there are several disadvantages such as atrophy of cortical bone inherent to …
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Amorphous, multi-phase polymer network systems with shape memory properties by photopolymerization
… and characterization of amorphous, covalent polymer network systems with shape-memory properties. The highest glass transition temperature of these networks serves as switching temperature Ttrans for the shape-memory effect. For potential applications in medicine, the material is designed to …
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Synthesis and Characterization of Poly(lactide) Functional Oligomers and Block Copolymers
Amphiphilic block copolymers consisting of poly(ethylene oxide) and poly(lactide) have great potential for formulating drug delivery systems. Our approach was to synthesize poly(ethylene oxide-b-D,L-lactide), (PEO-b-PDLLA), block copolymers with controlled molecular weights and good functionality …
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Design, production and evaluation of an auxetic straining device for application in lung tissue engineering scaffolds
… uniaxial loading into biaxial expansion. Poly-L-lactide and polypropylene re-entrant honeycomb auxetic meshes were 3D-printed and incorporated into collagen scaffolds. Computational simulations were undertaken, and it was predicted that a 0.03 uniaxial tensile strain would induce a 6% …
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Preparation and Functionalization of Macromolecule-Metal and Metal Oxide Nanocomplexes for Biomedical Applications
Copolymer-cobalt complexes have been formed by thermolysis of dicobalt octacarbonyl in solutions of copolysiloxanes. The copolysiloxane-cobalt complexes formed from toluene solutions of PDMS-b-[PMVS-co-PMTMS] block copolymers were annealed at 600-700 °C under nitrogen to form protective siliceous …
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Synthesis, Characterization and Structure-Property Relationships of Polymer-Stabilized Nanoparticles Containing Imaging and Therapeutic Agents
… of drugs. This work describes the fabrication of polymer-stabilized nanoparticles encapsulating imaging and therapeutic agents and delineates relationships among materials parameters and response. The effect of aggregation of magnetic iron oxide nanoparticles in aqueous suspension was …
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In vitro inflammatory response evaluation of pre-degraded bioresorbable polymers
Bioresorbable polymers composed of poly(lactide), poly(glycolide) and their related copolymers have become increasingly popular in the biomedical field, and especially for the preparation of bone substitute constructs. However, there are reports of a delayed inflammatory reaction occurring months …
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Amphiphilic Poly(2-isopropyl-2-oxazoline)-block-poly(lactide) Nanoparticles as Drug Delivery Vehicles
… of the unique morphologies of water-soluble poly(2-isopropyl-2-oxazoline)-block-poly(DL-lactide) and poly(2-isopropyl-2-oxazoline)-block-poly(L-lactide) (PiPOx-b-PDLLA and PiPOx-b-PLLA) nanoparticles was obtained via Fluorescence Spectroscopy. Additionally, loading and release studies were …
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Production and characterisation of bioresorbable polymers and polymer-glass composites for application in cardiac stents
Bioresorbable polymeric cardiac stents are a promising technology for treating cardiovascular diseases, but current poly-L-lactide (PLLA) stents have been limited by poor mechanical properties and slow degradation. Materials with increased strength and stiffness are needed, to reduce the required …
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Pentablock copolymers based controlled release formulations of small and macromolecules for ophthalmic applications
Pentablock copolymers comprised of multi-polymer blocks such as polyethylene glycol (PEG), polycaprolactone (PCL) and poly-lactide (PLA) were developed for fabrication of nanoparticles and thermosensitive hydrogel formulations for long term delivery of small and macromolecules. Different pentablock …
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Histopathologische Untersuchungen auf organische Veränderungen nach intraossärer Implantation von Poly(L-Lactid), Polymethyl-Methacrylat und kommerziell reinem Titan bei der Ratte
… aus a.) kommerziell reinem (cp) Titan, b.) Polymethyl-Methacrylat (PMMA) und c.) niedrig molekularem, amorphem Poly(L-Lactid) (Molekulargewicht Mvis: 120 000) wurden in das linke Femur von jeweils 25 spezifiziert pathogenfreien (SPF) Sprague Dawley-Ratten implantiert. Zwei weitere Gruppen …
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Poly(p-xylylene) Nanotubes Prepared via the Tubes by Fiber Templates Process as Catalytic Nanoreactors
… nonwovens were coated from the gas phase with poly(p-xylylene) (PPX), based on the chemical vapor deposition process. Subsequently, the inner template material of the corresponding core-shell fibers was removed using either solvent extraction or pyrolysis. Accordingly, nanotubes with …
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Development and characterization of biodegradable microspheres containing selected antimycobacterials.
… with protracted dosage regimens. Biodegradable poly-a-hydroxy acid microspheres and microcapsules containing rifampicin (RIF) and isoniazid (INH) respectively have been prepared with the intention of providing high sustained site-specific concentrations to overcome some of the shortcomings of …
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