Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 53 for “"poly(I:C)"”.
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Anti-inflammatory Role of IL-15Rα Up-regulated by Poly I:C in Herpes Simplex Virus-induced Behcet's Disease-like Mouse Model
… CD8+ T cells. Recent studies informed that Polyinosinic:polycytidylic acid (Poly I:C) is an immunostimulant which boosts the generation of memory T cells though induction of IL-15 and IL-15Rα. We found that the frequencies of IL-15Rα were significantly lower in HSV-induced BD mouse model …
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Behavioral analysis of piglets exposed to a second immune challenge following maternal immune activation
… syndrome virus (PRRSV). The viral mimetic polyinosinic-polycytidylic acid (Poly(I:C)) elicits immune response akin to a viral challenge, yet the effect of this immune stimulant on pig behavior has not been assessed. The present study advances the understanding of the combined effect of MIA …
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Mouse Melanoma Model for Evaluating Anti-Cancer Effects of Nanoparticles, Composites and Conjugates
… disease may be hindered by the targeting of a poly I:C-nanoconjugate treatment. This study will examine the potential of poly I:C and specific nanomaterials in combination to target melanoma through direct induction of apoptosis and influence of the host immune response. Specific …
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Brain Endothelial Cells Orchestrate an Anti-Encephalitic State in the Central Nervous System in Response to Peripheral Viral Infection
… on the offending insult. Viral motifs like poly(I:C) elicit antiviral genes whereas bacterial components like lipopolysaccharide accurate antibacterial pathways. Lastly, we show that the brain does not respond unless a physiological barrier is breached by contrasting the lack of CNS immune …
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Sequence and structure requirements of Y RNA-derived small RNA biogenesis
… a number of human cell lines were treated with Poly(I:C), a mimic of viral infection, and the levels of small RNAs were examined by next generation sequencing. Surprisingly, we did not �nd many di�erentially expressed microRNAs, but we discovered a new class of small RNAs that were 30-35 …
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Proteomic analysis of TRIF interactome and functional characterisation of novel TRIF interacting proteins
… to interact with TRIF at 60 and 20 min. upon poly(I:C) and LPS stimulation, respectively. Overexpression of ADAM15 in HEKT293, HEK293-TLR3 and HEK293-TLR4 inhibited TRIF, TLR3 and TLR4-dependent activation of NF-κB, IFNβ and Rantes promoter activation, respectively. Moreover, downregulation of …
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Einfluss rekurrierender Exposition gegenüber TLR3-Liganden auf Lungenfunktionstrajektorien
… wurden juvenile Mäuse rekurrierend mit poly(I:C) behandelt. Phase 1 umfasste Lungenfunktionsmessungen, Immunzell-Analysen und histologische Untersuchungen. In der zweiten Phase wurde die Pathogenese von Asthma mit dem HDM-Modell untersucht und dabei die Asthma-Parameter untersucht. Phase …
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Innate Immunity in Chickens: In Vivo Responses to Different Pathogen Associated Molecular Patterns
… the smallest immunostimulatory unit of PGN, and poly I:C the dsRNA analog. PAMP recognition by and stimulation of the innate immune system is crucial to an individual’s ability to quickly limit microbial growth and stimulate the adaptive immune system. Characterization of the in vivo immune …
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Role of CD44, Fas Ligand, and Perforin in the Cytotoxicity Mediated by Natural Killer Cells
… We observed that both interleukin-2 (IL-2) and Poly I:C triggered NK/LAK cells to lyse targets through the perforin- and FasL- pathways. In addition, Fas+ tumor targets were more susceptible to lysis by poly I:C and IL-2 activated NK/LAK cells when compared to Fas- targets. Furthermore, Fas- …
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TLR3 Signaling in Human BDCA-3 Dendritic Cells Results in the Formation of Several ILT3 and ILT4 Populations
… and CD141 or BDCA-3. Stimulating BDCA-3 DCs with Poly I:C, a toll-like receptor (TLR) 3 agonist, resulted in the up-regulation of various canonical activation markers such as CD40, CD80, and CD86 as well as immunoglobulin-like transcript (ILT) 3 and 4 as measured by flow cytometry. ILTs are novel …
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The impact of viral infection during pregnancy on maternal immunity and fetal brain development
… is often modeled using pathogen mimics, like poly I:C. While these models have provided invaluable mechanistic insights, poly I:C induces only a partial innate immune response, whereas replicating IAV elicits a complete innate and adaptive immune response. To address this gap, we tested two of …
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Stat3 Inhibits Type I Interferon Signaling In Type I Conventional Dendritic Cells
… immunity. Herein, we show that IL-10 inhibits polyinosinic:polycytidylic acid (poly I:C)-induced cDC1 maturation in a STAT3-dependent manner. Transcriptome analyses further revealed that although poly I:C induces numerous inflammatory pathways in cDC1s, interferon (IFN) signaling was …
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Interaktion von inflammatorisch aktivierten retinalen Pigmentepithelzellen mit retinaler Mikroglia und neuronalen Zellen
… zum Einsatz: Pam2CSK4 (Pam; TLR-2), Polyinosin-Polycytidylsäure (Poly I:C; TLR-3) und Lipopolysaccharid (LPS; TLR-4). Die Zellviabilität wurde mittels MTT-Assay bestimmt. Die Zytokinsekretion wurde per ELISA und die Expression mittels Real-Time PCR analysiert. Die Agonisten hatten …
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Effect of Medicinal Herbal, Panax Notoginseng, on the Fate and Function of Professional Antigen Presenting Cells
… with the toll-like receptor ligands LPS, CpG and poly(I:C) and treated with notoginseng (0-200 ìg/ml). The LPS induced levels of the proinflammatory cytokine TNF-á, as well as the expression of accessory molecules MHC II, CD40 and CD86, were decreased dependent on notoginseng exposure time-points …
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Effect of Medicinal Herbal, Panax Notoginseng, on the Fate and Function of Professional Antigen Presenting Cells
… with the toll-like receptor ligands LPS, CpG and poly(I:C) and treated with notoginseng (0-200 ìg/ml). The LPS induced levels of the proinflammatory cytokine TNF-á, as well as the expression of accessory molecules MHC II, CD40 and CD86, were decreased dependent on notoginseng exposure time-points …
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Exploring the molecular basis to the regulatory effects of Cannabinoids on toll-like receptor signalling
… in the presence of the TLR3 ligand, Poly(I:C), targets interferon regulatory factor 3 (IRF3), a transcription factor essential for regulating type I interferon (IFN) expression. These findings also demonstrate that protective effects of R(+)WIN55,212-2 in EAE mice exist, as evidenced …
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Dendritic cell dysfunction restrains cytotoxic T cell responses against cancer
… DCs in both the tumor and tdLN. Treatment with Poly(I:C) could enhance T cell and DC responses at later timepoints, providing a clear rationale for combination immunotherapy using Poly(I:C) and ICB. Our work demonstrates that distinct tissue-specific and temporal elements can suppress DC ability …
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Probing the Mechanisms Underlying the Regulatory Effects of Cactin in Innate Immune Signalling Pathways
… observed in response to the TLR ligands LPS and Poly(I:C). Cactin also negatively regulates the activation of IRF3 and IRF7 and suppression of endogenous Cactin augments Poly(I:C)-mediated IFNβ induction. Cactin localises to the nucleus by virtue of two nuclear localisation sequences (NLS)s and …
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Precision-cut placental slices as a model to study inflammatory response
… preparáty byly vystaveny různým koncentracím lipopolysacharidu (LPS) nebo Polyinosinické: polycytidylové kyseliny (Poly I:C) po dobu 4 až 18 hodin....
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