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Showing 1 to 13 of 13 for “"poly(ADP-ribosyl)ation"”.

  1. Chemical Tools to Monitor and Inhibit poly(ADP -Ribosyl)ation

    Boye, AmandaUniversity of Illinois at Urbana-Champaign2015

    … no crystal structure of the complementary enzyme poly(ADP-ribose)glycohydrolase (PARG) is available, and therefore it has been difficult to intelligently design compounds to inhibit this enzyme. To date, the known inhibitors of PARG can be predominantly grouped into the three categories of DNA …

    uiuc Repository record

  2. Partial characterization of poly(ADP-ribosyl)ation in the brine shrimp Artemia.

    Gorski, Martin Matthew.University of Windsor1989

    Source: Masters Abstracts International, Volume: 40-07, page: . Thesis (M.Sc.)--University of Windsor (Canada), 1989.

    windsor Repository record

  3. Role of CTCF Poly(ADP-ribosyl)ation in the regulation of cellular functions

    Pavlaki, IoannaUniversity of Essex2015

    essex Repository record

  4. Chemical approaches to understanding small-molecule accumulation in bacteria and poly(ADP-ribosyl)ation

    Drown, Bryon ShaneUniversity of Illinois at Urbana-Champaign2019

    … the potential impact of this kind of approach. Poly(ADP-ribose) (PAR) signaling is an important component of DNA damage repair, cell division regulation, and initiation of controlled cell death. Despite extensive knowledge and a powerful toolkit available for studying the synthesis of PAR …

    uiuc Repository record

  5. Toward a Quantitative Analysis of PARP-1 and Poly(ADP-ribosyl)ation in Cellular Senescence

    Edmonds, Yvette M.Virginia Tech2010

    … evidence to suggest a connection between poly(ADP-ribose) (PAR) and mammalian longevity, no studies have been done to explore a possible role for PARP-1 — the enzyme responsible for synthesis of 90% of cellular PAR — in mechanisms of senescence. Furthermore, many techniques currently used …

    vt Repository record

  6. Changes in Mammalian Chromatin Structure as a Function of Protein-Poly(ADP-Ribosyl)ation by Endonuclease Digestion

    Perez-Lamigueiro, Maria A.2004

    … Chromatin Structure as a Function of Protein-poly(ADP-ribosyl)ation by Endonuclease Digestion. Master of Science (Biochemistry and Molecular Biology), June 2004. 66 pages, 12 illustrations, Bibliography, 45 titles. Mammalian chromatin was exposed to either Deoxyribonuclease I or Micrococcal …

    tdl Repository record

  7. 3-Nitropropionic acid induces poly (ADP-ribosyl) ation and apoptosis related gene expression in the striatum in vivo

    Sugino, ToshiyukiKyoto University2000

    kyoto Repository record

  8. Development of methods to investigate poly(ADP-ribose) polymerase-1 activity and DNA base-excision repair in relation to cancer and ageing

    Pfeiffer, RagenUniversität Heidelberg

    … of a new immuno-dot-blot method to detect poly(ADP-ribosyl)ation capacity in cells and the automation of the fluorescence detected alkaline DNA unwinding (FADU) assay to measure DNA strand breaks and repair. Poly(ADP-ribose) polymerase-1 (PARP-1) is involved in DNA base-excision repair and …

    heid-diss Repository record

  9. Taurine depletion and Schwann cell dysfunction in diabetic neuropathy

    Askwith, TrevorUniversity of Birmingham2010

    … taurine and in animal models taurine supplementation ameliorates neuropathic symptoms. The mechanisms behind Taurine depletion and taurine supplementation are not well understood. Schwann cells are highly vulnerable to hyperglycaemia-induced stress which plays a key role in the pathogenesis of …

    birmingham Repository record

  10. Strategies for structural studies of poly(ADP-ribose) glycohydrolase: Towards the validation of a novel therapeutic target

    Botta, DavideThe University of Arizona.2010

    Poly(ADP-ribosyl)ation is a reversible post-translational modification of histones and nuclear proteins rapidly stimulated by DNA damage. Its homeostasis is a dynamic process regulated by the synthesizing enzymes poly(ADP-ribose) polymerases (PARPs) and the degrading enzyme poly(ADP-ribose) …

    arizona-thes Repository record

  11. Functional characterization of poly(ADP-ribose) dependent ubiquitin E3 ligase in the DNA damage response

    김, 재진2016

    … 1 B. DNA damage repair 3 1. Homologous recombination (HR) 4 2. Nonhomologous end joining (NHEJ) 5 C. Ubiquitylation mediated DNA damage response signaling 6 1. Ubiquitylation 6 2. Post-translational modification mediated DNA damage response 7 3. RNF4 functions in the DNA damage response 8 4. …

    ajou Repository record

  12. Phopsphorylation and Ubiquitin Modification At Dna Damage Sites In Response to Double-Strand Breaks

    Paul, Atanu, <p>http://www.orcid.org/0000-0003-2241-5066</p>2019

    … DDR factors recruitment, retention and dissociation from the sites of DNA damage in a spatiotemporal manner mediated by numerous reversible post-translational modification (PTMs) including phosphorylation, ubiquitination, SUMOylation, methylation, acetylation, poly(ADP-ribosyl)ation, and …

    uthsc Repository record

  13. Design and Applications of Split-Luciferase Systems in Vitro and in Cellulo

    Mok, Pui-WingThe University of Arizona.2014

    … to the specific detection of DNA, DNA modifications, and small molecule kinase inhibitors both in vitro and in cellulo. We have previously developed one of the first direct methods to detect any double stranded DNA sequence by attaching DNA binding domains, specifically designed Cys₂-His₂ zinc …

    arizona-thes Repository record