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Showing 1 to 20 of 67 for “"poly(ADP-ribose polymerase)"”.

  1. Poly (ADP-ribose) polymerase-1 (PARP-1) induces human trophoblast syncytialization

    Pater, JustinUniversity of Saskatchewan2013

    … a cytoplasmic adapter protein. Nuclear enzyme Poly ADP-ribose Polymerase-1 (PARP-1) and the transcriptional repressor Snail-1 work with ILK to downregulate epithelial cell-cell adhesion. This process would also be necessary for proper trophoblast syncytialization. Thus, it was hypothesized that …

    sask Repository record

  2. Structure and function of the human Poly(ADP-ribose) polymerase enzyme family

    Rood, Jennifer E. (Jennifer Evelyn)Massachusetts Institute of Technology2013

    The poly(ADP-ribose) polymerase (PARP) family of enzymes in humans is comprised of 17 proteins. PARP-1, the first member of the family, synthesizes a large, complex post-translational modification, poly(ADP-ribose). While PARP-1 and some other PARPs have been extensively functionally characterized, …

    mit Repository record

  3. Cellular functions and enzymatic activity of the poly(ADP-ribose) polymerase protein family

    Vyas, Sejal (Sejal Kamlesh)Massachusetts Institute of Technology2014

    The poly(ADP-ribose) polymerase (PARP) protein family consists of seventeen enzymes and generates ADP-ribose (ADPr) posttranslational modifications onto target proteins using NAD* as a substrate. While functions for PARPs in the nucleus, such as in DNA damage repair and transcriptional regulation, …

    mit Repository record

  4. Poly (Adp) Ribose Polymerase Inhibitors For The Treatment of Malignant Peripheral Nerve Sheath Tumor

    Kivlin, Christine M2016

    … to improve the outcome for MPNST patients. Poly (ADP) ribose polymerase (PARP) inhibitors were first reported over a decade ago to have substantial anti-tumorigenic effects in malignancies with defective DNA repair, specifically those with <em>BRCA1/2</em> (breast cancer, early onset …

    uthsc Repository record

  5. Untersuchungen zur Inhibierung der Expression der Poly(ADP-ribose)Polymerase (PARP) nach Infektion mit Toxoplasma gondii

    Gais, Andrea Nadja2012

    … Apoptose auch die Inhibierung der Expression der Poly(ADP-Ribose) Polymerase (PARP)-1. PARP-1 ist ein nukleäres Protein und spielt eine wichtige Rolle in verschiedenen zellulären Abläufen einschließlich DNA Reparatur, Apoptose, Nekrose und Regulation der Genexpression. Außerdem ist es an der …

    goettingen Repository record

  6. The role of Poly (ADP-ribose) polymerase in the regulation of innate recognition of immunological receptors expressed on human macrophages.

    Mohamad, Kamaran KarimUniversity of Essex2016

    … and macrophages. CD14 recognizes and bind lipopolysaccharide (LPS), the main causative agents of sepsis and endotoxic shock. Signaling from CD14-LPS and TLR4/MD-2 complex activate the nuclear factor kappa B (NF-κB) family of transcription factors and JNK, a member of MAP kinase (MAPK) family. …

    essex Repository record

  7. Differentiation-associated Downregulation of Poly(ADP-Ribose) Polymerase-1 (PARP-1) Expression in Skeletal Muscle Increases Its Resistance to Oxidative Stress

    Oláh, Gábor2016

    hungary-te Repository record

  8. Development of methods to investigate poly(ADP-ribose) polymerase-1 activity and DNA base-excision repair in relation to cancer and ageing

    Pfeiffer, RagenUniversität Heidelberg

    … of a new immuno-dot-blot method to detect poly(ADP-ribosyl)ation capacity in cells and the automation of the fluorescence detected alkaline DNA unwinding (FADU) assay to measure DNA strand breaks and repair. Poly(ADP-ribose) polymerase-1 (PARP-1) is involved in DNA base-excision repair and …

    heid-diss Repository record

  9. Modulation of Transcription Factor Chromatin Association and Gene Transcription Program in Embryonic Stem Cell and Triple Negative Breast Cancer by Poly (ADP-Ribose) Polymerase 1

    Liu, Ziying2018

    Pages ix-xvi are incorrectly numbered as pages xiv-xxi.

    utswmed Repository record

  10. Monosacchacharid-Konjugate von Inhibitoren der O6-Methylguanin-DNA Methyltransferase, der Poly-(ADP-ribose) Polymerase und des SWITCH Phänomens des HIV Hüllproteins gp120 : Synthese, biologische Aktivität und Struktur-Wirkungsbeziehungen

    Reinhard, JostUniversität Heidelberg

    In dieser Arbeit wurden acetyl- oder benzoylgeschützte Bromoalkyl-Glucoside synthetisiert, die zur Einführung von Glycosylalkylresten in verschiedene Moleküle geeignet sind. So wurden O6-substituierten Purine zu MGMT-Inhibitor-Glucosiden, eine Hydroxyphenyl-benzimidazol-Grundstruktur zu …

    heid-diss Repository record

  11. Angiotensin Type-2 (At2) Receptor Modulation of Nmda-Mediated Current, Signaling and Apoptosis

    Andres, Robert DouglasUniversity of Illinois at Urbana-Champaign2015

    … inhibits cleavage of the DNA repair enzyme poly-(ADP-ribose) polymerase (PARP) following treatment with NMDA. Inhibition of ERK with MEK inhibitors (PD98059 and U0126) significantly decreased PARP cleavage (cPARP), while inhibition of PP2A with 10 nM okadaic acid, significantly increased …

    uiuc Repository record

  12. Mechanismen der Toxoplasma-gondii-vermittelten Inhibierung der Apoptose in humanen Wirtszelllinien

    Goebel, StefanUniversität Würzburg

    … werden. Zweitens wird die Expression der Poly-(ADP-Ribose)Polymerase (PARP) durch T. gondii inhibiert. Beide Mechanismen könnten an der Inhibierung der Wirtszellapoptose durch T. gondii beteiligt sein und dem Parasiten damit sein intrazelluläres Überleben sichern.

    wurz-thes Repository record

  13. Investigating the Role of PARylation in Regulating Skeletal Muscle Mass and Function in Healthy Mature Mice

    Pandey, DheerajUniversité d'Ottawa / University of Ottawa2023

    Adenosine diphosphate (ADP) ribosylation is a post-translational modification dependent on the transfer of ADPr units from nicotinamide adenine dinucleotide (NAD+) on to a plethora of biomolecules (i.e., proteins, DNA, RNA, etc.) in response to physiological stressors (i.e., nutrient deprivation, …

    ottawa-retro Repository record

  14. Nicotinamide Riboside Delivery Generates NAD+ Reserves to Protect Vascular Cells Against Oxidative Damage

    Hawrylyshyn, Krista MThe University of Western Ontario2015

    … critical to vascular health. NAD+, which drives poly (ADP-ribose) polymerase (PARP) and sirtuin (SIRT) reactions, can be compromised and strategies for overcoming this limitation in the vasculature do not exist. This study determines if nicotinamide riboside (NR) delivery can augment NAD+ stores …

    uwo Repository record

  15. Nprl2/Tusc4 Functions As A Tumor Suppressor By Regulating Brca1’S Stability Via The E3 Ubiquitination Pathway

    Peng, Yang2014

    … of NPRL2/TUSC4 expression enhanced BRCA1 polyubiquitination, leading to BRCA1 protein degradation and a marked reduction in HR repair efficiency. Conversely, ectopic expression of NPRL2/TUSC4 effectively suppressed the proliferation, invasion, and colony formation of breast cancer cells …

    uthsc Repository record

  16. Role of C-Met and Egfr In Acquired Resistance to Parp Inhibitors In Triple-Negative Breast Cancer

    Yam, Clinton, <p><a href="https://orcid.org/0000-0002-0809-0851?lang=en" target="_blank">https://orcid.org/0000-0002-0809-0851</a></p>2020

    … prognosis and treatment options are limited. The Poly (ADP-ribose) polymerase (PARP) inhibitors, olaparib and talazoparib, were recently approved for metastatic breast cancer (including triple-negative breast cancer) in patients with a germline <em>BRCA1/2</em> mutation. Despite impressive …

    uthsc Repository record

  17. Development of Rational Combination Therapy With Parp Inhibitors and Kinase Inhibitors In Tnbc

    Yu, Wen-Hsuan2017

    <p>Poly (ADP-ribose) polymerase inhibitors (PARPi) emerge as potential targeting drugs for BRCA-deficient cancers including triple negative breast cancer (TNBC). However, it has been reported that a subgroup of patients even with BRCA mutation fails to respond to PARPi in multiple clinical trials. …

    uthsc Repository record

  18. Folate Deficiency and Its Effect On Dna Repair

    Noxon, Virginia

    … the breast cancer cell line, MDA-MB-231, using polymerase beta; (Pol beta;) knockdown and add back sublines. The results showed that Pol beta; status affected the amount of DNA damaged caused by folate deficient conditions. Pol beta; status also affected subcellular localization of another BER …

    south-carolina Repository record

  19. MODELING COHESIN-DEPENDENT ONCOGENESIS IN VITRO AND IN VIVO: POSSIBLE AMELIORATIVE EFFECTS OF PARP INHIBITION

    TOTARO, SIMONAUniversità degli Studi di Milano2025

    … masses in the brain. I also showed that Poly (ADP-ribose) polymerase (PARP) depletion or inhibition which is used to treat forms of cancer with defects in DNA repair ameliorated phenotypes of SA-deficient animals. Finally, I studied the effect of STAG2 downregulation in human in vitro …

    milano Repository record

  20. Evaluation of selective γ-secretase inhibitors as novel modulators of TNF-α-mediated apoptosis

    O'Brien, CiaraUniversity College Cork2021

    … Utilizing the cleavage of caspase 3 and Poly ADP ribose polymerase (PARP) in target cells as a readout, we tested the anti-apoptotic characteristics of a panel of well characterized γ-secretase inhibitors. In this study, we show that loss of presenilin expression is associated with …

    cork Repository record

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