Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"poly(ADP-ribose) (PAR)"”.
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High-throughput screening for ADP-ribosyl hydrolase 3 inhibitors
Poly(ADP-ribose) (PAR) signaling is an important component of DNA damage repair, DNA replication, and initiation of parthanatos, a method of controlled cell death. While PAR has been well studied for decades, much is still unknown about PAR’s initiation of parthanatos and the importance of …
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Cellular functions and enzymatic activity of the poly(ADP-ribose) polymerase protein family
The poly(ADP-ribose) polymerase (PARP) protein family consists of seventeen enzymes and generates ADP-ribose (ADPr) posttranslational modifications onto target proteins using NAD* as a substrate. While functions for PARPs in the nucleus, such as in DNA damage repair and transcriptional regulation, …
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The discovery of small molecule inhibitors of poly(ADP-ribose) mediated cell death
… the repair of single strand DNA breaks by the poly(ADP-ribose) (PAR) cycle, which is an enzymatic cycle that promotes DNA repair after mild DNA damage. In contrast, upon severe DNA damage, the PAR cycle is known to promote acute cell death, which can result in ischemia or neurological diseases. …
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Strategies for structural studies of poly(ADP-ribose) glycohydrolase: Towards the validation of a novel therapeutic target
Poly(ADP-ribosyl)ation is a reversible post-translational modification of histones and nuclear proteins rapidly stimulated by DNA damage. Its homeostasis is a dynamic process regulated by the synthesizing enzymes poly(ADP-ribose) polymerases (PARPs) and the degrading enzyme poly(ADP-ribose) …
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Function and regulation of PARP13 binding to cellular RNA
Poly(ADP-ribose) polymerase-13 (PARP13) is a member of the PARP family of proteins - enzymes that use NAD+ to synthesize a posttranslational protein modification called poly(ADP-ribose) (PAR). PARPs function in multiple cellular pathways, and recently several members of the family have been …
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Chemical approaches to understanding small-molecule accumulation in bacteria and poly(ADP-ribosyl)ation
… helped establish this “antibiotic era.” In large part due to their remarkable success, antibiotics are today expected to be safe, cheap, and effective at a level unparalleled by any other class of drugs. The expansive use and misuse of antibiotics has caused a rise in antibiotic microbial …
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An Investigation Into The Mineral And Mechanical Properties Of The Canine Intervertebral Disc And Its Clinical Implications
… of neurological damage which can result in paralysis and leads to the death of many dogs annually. The disease is intimately associated with disc degeneration and calcification, but the precise mechanisms by which these pathological processes are linked remain a mystery. Degeneration of the …
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A Solid State NMR Investigation of Poly (ADP-ribose) and Its Involvement in Tissue Calcification
… its components. The Duer group discovered that poly (ADP-ribose) (PAR), a biological polymer produced in response to DNA damage, is deposited in the calcified matrix of bone and pathologically mineralised arteries and could play an important role in mineralisation. PAR has affinity for calcium, …
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Toward a Quantitative Analysis of PARP-1 and Poly(ADP-ribosyl)ation in Cellular Senescence
… evidence to suggest a connection between poly(ADP-ribose) (PAR) and mammalian longevity, no studies have been done to explore a possible role for PARP-1 — the enzyme responsible for synthesis of 90% of cellular PAR — in mechanisms of senescence. Furthermore, many techniques currently used …
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Natural history and pathogenesis of Takotsubo cardiomyopathy
… stress was performed in a rat model of TTC in parallel with human experiments looking at the local and systemic rise in the 3-nitrotyrosine (3-NT) as a footmark of ONOO⁻ formation. As a part of clinical investigations, we evaluated the role of RV involvement in early hemodynamic derangement. We …