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Showing 1 to 20 of 87 for “"poly(ADP-ribose)"”.
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Enzymatic synthesis of defined-length poly(ADP-ribose) and the investigation of cell-permeable poly(ADP-ribose) glycohydrolase inhibitors
Poly(ADP-ribosylation) (PARylation) is an important post-translational modification that maintains genomic stability in a cell. Engaging in important cellular processes such as DNA repair and cell death signaling, PARylation has gathered considerable interest as a target for genotoxic chemotherapy …
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The chemical and enzymatic synthesis of poly(ADP-ribose)
Poly(ADP-ribose) synthesis and degradation are important cellular processes associated with the DNA damage response and many other pathways. Traditionally, these processes have been challenging to study due to the heterogeneity associated with the synthesis of poly(ADP-ribose). Discussed here are …
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Poly (ADP-ribose) polymerase-1 (PARP-1) induces human trophoblast syncytialization
… a cytoplasmic adapter protein. Nuclear enzyme Poly ADP-ribose Polymerase-1 (PARP-1) and the transcriptional repressor Snail-1 work with ILK to downregulate epithelial cell-cell adhesion. This process would also be necessary for proper trophoblast syncytialization. Thus, it was hypothesized that …
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Structure and function of the human Poly(ADP-ribose) polymerase enzyme family
The poly(ADP-ribose) polymerase (PARP) family of enzymes in humans is comprised of 17 proteins. PARP-1, the first member of the family, synthesizes a large, complex post-translational modification, poly(ADP-ribose). While PARP-1 and some other PARPs have been extensively functionally characterized, …
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Development of poly(ADP-ribose) glycohydrolase inhibitors and tetracyclic indoles as anticancer compounds
… herein is the target-based development of poly(ADP-ribose) glycohydrolase (PARG) inhibitors as putative anticancer compounds as well as the discovery of a class of potent anticancer tetracyclic indoles through a phenotypic screen. PARG plays a crucial role in DNA damage repair, and lack of …
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The discovery of small molecule inhibitors of poly(ADP-ribose) mediated cell death
… the repair of single strand DNA breaks by the poly(ADP-ribose) (PAR) cycle, which is an enzymatic cycle that promotes DNA repair after mild DNA damage. In contrast, upon severe DNA damage, the PAR cycle is known to promote acute cell death, which can result in ischemia or neurological diseases. …
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Cellular functions and enzymatic activity of the poly(ADP-ribose) polymerase protein family
The poly(ADP-ribose) polymerase (PARP) protein family consists of seventeen enzymes and generates ADP-ribose (ADPr) posttranslational modifications onto target proteins using NAD* as a substrate. While functions for PARPs in the nucleus, such as in DNA damage repair and transcriptional regulation, …
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Poly (Adp) Ribose Polymerase Inhibitors For The Treatment of Malignant Peripheral Nerve Sheath Tumor
… to improve the outcome for MPNST patients. Poly (ADP) ribose polymerase (PARP) inhibitors were first reported over a decade ago to have substantial anti-tumorigenic effects in malignancies with defective DNA repair, specifically those with <em>BRCA1/2</em> (breast cancer, early onset …
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Functional characterization of poly(ADP-ribose) dependent ubiquitin E3 ligase in the DNA damage response
… 1 functions in the DNA damage response 9 D. Poly(ADP-ribosyl)ation mediated DNA damage response signaling 10 1. DNA damage induced PARP1 activation 10 2. Free pADPr polymer function in DNA damage response 11 E. Aim of this study 12 Ⅱ. MATERIAL AND METHODS 13 1. Cell lines 13 2. Plasmids and …
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A Solid State NMR Investigation of Poly (ADP-ribose) and Its Involvement in Tissue Calcification
… its components. The Duer group discovered that poly (ADP-ribose) (PAR), a biological polymer produced in response to DNA damage, is deposited in the calcified matrix of bone and pathologically mineralised arteries and could play an important role in mineralisation. PAR has affinity for calcium, …
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Untersuchungen zur Inhibierung der Expression der Poly(ADP-ribose)Polymerase (PARP) nach Infektion mit Toxoplasma gondii
… Apoptose auch die Inhibierung der Expression der Poly(ADP-Ribose) Polymerase (PARP)-1. PARP-1 ist ein nukleäres Protein und spielt eine wichtige Rolle in verschiedenen zellulären Abläufen einschließlich DNA Reparatur, Apoptose, Nekrose und Regulation der Genexpression. Außerdem ist es an der …
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Strategies for structural studies of poly(ADP-ribose) glycohydrolase: Towards the validation of a novel therapeutic target
Poly(ADP-ribosyl)ation is a reversible post-translational modification of histones and nuclear proteins rapidly stimulated by DNA damage. Its homeostasis is a dynamic process regulated by the synthesizing enzymes poly(ADP-ribose) polymerases (PARPs) and the degrading enzyme poly(ADP-ribose) …
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The role of Poly (ADP-ribose) polymerase in the regulation of innate recognition of immunological receptors expressed on human macrophages.
… and macrophages. CD14 recognizes and bind lipopolysaccharide (LPS), the main causative agents of sepsis and endotoxic shock. Signaling from CD14-LPS and TLR4/MD-2 complex activate the nuclear factor kappa B (NF-κB) family of transcription factors and JNK, a member of MAP kinase (MAPK) family. …
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Development of methods to investigate poly(ADP-ribose) polymerase-1 activity and DNA base-excision repair in relation to cancer and ageing
… of a new immuno-dot-blot method to detect poly(ADP-ribosyl)ation capacity in cells and the automation of the fluorescence detected alkaline DNA unwinding (FADU) assay to measure DNA strand breaks and repair. Poly(ADP-ribose) polymerase-1 (PARP-1) is involved in DNA base-excision repair and …
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Modulation of Transcription Factor Chromatin Association and Gene Transcription Program in Embryonic Stem Cell and Triple Negative Breast Cancer by Poly (ADP-Ribose) Polymerase 1
Pages ix-xvi are incorrectly numbered as pages xiv-xxi.
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Monosacchacharid-Konjugate von Inhibitoren der O6-Methylguanin-DNA Methyltransferase, der Poly-(ADP-ribose) Polymerase und des SWITCH Phänomens des HIV Hüllproteins gp120 : Synthese, biologische Aktivität und Struktur-Wirkungsbeziehungen
In dieser Arbeit wurden acetyl- oder benzoylgeschützte Bromoalkyl-Glucoside synthetisiert, die zur Einführung von Glycosylalkylresten in verschiedene Moleküle geeignet sind. So wurden O6-substituierten Purine zu MGMT-Inhibitor-Glucosiden, eine Hydroxyphenyl-benzimidazol-Grundstruktur zu …
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Investigating the Role of PARylation in Regulating Skeletal Muscle Mass and Function in Healthy Mature Mice
Adenosine diphosphate (ADP) ribosylation is a post-translational modification dependent on the transfer of ADPr units from nicotinamide adenine dinucleotide (NAD+) on to a plethora of biomolecules (i.e., proteins, DNA, RNA, etc.) in response to physiological stressors (i.e., nutrient deprivation, …
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Chemical Tools to Monitor and Inhibit poly(ADP -Ribosyl)ation
… no crystal structure of the complementary enzyme poly(ADP-ribose)glycohydrolase (PARG) is available, and therefore it has been difficult to intelligently design compounds to inhibit this enzyme. To date, the known inhibitors of PARG can be predominantly grouped into the three categories of DNA …
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Studies of PARP-1 activation and inhibition using NMR spectroscopy
Poly(ADP-ribose)polymerase 1 (PARP-1) is a highly abundant multi-domain chromatin-associated enzyme found in all higher eukaryotic cell nuclei. It is the founding member of the PARP family of enzymes that modify themselves and other proteins by adding negatively charged poly(ADP-ribose) chains …
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