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Showing 1 to 20 of 21 for “"poloxamer"”.
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Understanding self-assembly and flow heterogeneities in poloxamer wormlike micelles
… polymers. The most well-studied of these are poloxamers, ABA block polymers formed from two polyethylene oxide (PEO) end blocks and one polypropylene oxide (PPO) midblock. Poloxamers have the potential to form WLMs with a range of rheological properties due to the tunability block composition. …
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Membrane Stabilizing Copolymer Poloxamer 188 in Preclinical Models of Acute Myocardial Infarction Reperfusion
… dysfunction and mitigate reperfusion injury. Poloxamer 188 (P188) is the most studied member of the poloxamer family, comprised of non-ionic polymers made of a hydrophobic core, flanked by hydrophilic end chains. Due to its membrane stabilizing and anti-coagulant properties, P188 remains a …
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Design of Thermosensitive Hydrogel for Extended-Release of Praziquantel
… hydrogel formulation based on poloxamer 407 (20%, w/v) was prepared, and two strategies for modifications of poloxamer 407 hydrogel were studied. One of them was the formulation consisting of PEG-DSPE/TPGS mixed micelles-poloxamer 407 hydrogel hybrid system; another was the …
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Dynamics of membrane damage to skeletal muscle cells at supraphysiological temperatures and the role of poloxamer 188 in minimizing membrane injury
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1994.
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Surface Modified Solid Lipid Curcumin Nanoparticles For Oral Delivery
… Two different stabilizers namely, PVA and poloxamer 407 were used for this purpose. The particles size (PS) and zeta potential (ZP) of nanoemulsion were determined at different stages of preparation using zetameter. The physical stability of the nanoemulsion was studied at 25⁰C over a …
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Physicochemical and tableting properties of crystallised and spray-dried phenylbutazone containing polymeric additives. Effect of polymeric additives (hydroxypropyl methylcellulose and a polyoxyethylene-polyoxypropylene glycol) on the crystalline structure, physicochemical properties and tableting behaviour of crystallised and spray-dried phenylbutazone powders
… (H. P. M. C. ) and the surfactant poloxamer 188 - prepared by both conventional crystallisation and spray drying are reported. As an integral nart of the work attempts were mado to identify the different polymorphic forms of phenylbutazone. The 6-form, the cammerdiallý 4- available …
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Desenvolvimento de sistemas terapêuticos para leishmaniose cutânea
… microemulsions (ME) containing 14 %w/w of poloxamer 407 were developed, which provided to the system a thermoreversible behavior (gelation in situ at ~ 25 °C), facilitating its topical application. The poloxamer 407 attenuated the instability phenomena in the ME system during the storage …
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A preliminary study evaluating potential probiotic use in endodontics
… 2 was conducted by mixing 9 ml of 30% poloxamer 407 and MRS broth in a test tube with 500 ml of either E. f or C. a set at a 1 McFarland standard, together with 500ml of either Group I or Group IV probiotic mixtures, set at a 2 McFarland standard. Samples were incubated at 37°C for …
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Preparation and characterization of multifunctional chitosan microparticles for lung delivery
… made water dispersible by adding an oleic acid-poloxamer coat to the surface of the iron oxide particles. These nanoparticles were incorporated into chitosan microparticles along with gemcitabine by spray drying using a Buchi Mini Spray dryer B-290. The particle size of iron oxide nanoparticles …
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Demulsification and recycling of spent oil based drilling fluid as nanofiller for polyamide 6 nanocomposites.
… of isopropanol, sodium dodecyl sulphate, poloxamer, sodium chloride, chitosan in 0.2M acetic acid and deionised water for demulsifier S4 and addition of phosphoric acid for demulsifier S3. Hydrocarbon reduction on the extracted solid phase nanofiller S3 and nanofiller S4 was 98.6% and …
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Diseño y evaluación de micropartículas conteniendo Meloxicam
… de las Dispersiones Sólidas, del Meloxicam y del Poloxamer 188 utilizado para su obtención. Se incluye una extensa revisión bibliográfica que respalda el trabajo. En el Capítulo II se presentan todos los materiales utilizados en las distintas etapas de desarrollo. Asimismo, se exponen las técnicas …
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Formulation and physico-chemical characterisation of novel films and wafers for mucosal drug delivery
… from two polymers (κ-carrageenan (CAR) 911 and poloxamer 407 (P407)), two types of plasticizers (glycerol (GLY)) and various grades of polyethylene glycol (PEG) using paracetamol (PM), ibuprofen (IBU) and indomethacin (IND) as model drugs. The investigations involved extensive …
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Physico-chemical studies of block copolymers in aqueous solution
… ) and diblock copolymers (3450-13300gmol-1 ), poloxamers (POE-POP-POE triblock copolymers, 1100-14000gmol-1 ) and poloxamines (ethylene diamine alkoxylates, 1650-26000gmol-1 )] using the macroscopic techniques of high sensitivity differential scanning calorimetry (HSDSC), and differential …
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Mid-IR Imaging and Multivariate Analysis of Dynamic Processes in Pharmaceutically Relevant Microparticles
… in the number of oxygenated components in the Poloxamer 407 excipient, thereby increasing the strength of interaction between the microparticle and the entrapped hGH. These findings suggest that any γ sterilisation dose should be less than 25 kGy and that other sterilisation methods may need to …
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Towards a more efficacious treatment for Oropharyngeal Candidiasis (OPC): Hydrogel-forming tablets for the controlled release delivery of Chlorhexidine diacetate
… cavity for two hours. They were prepared using Poloxamer 407 (P407), hydroxypropyl methylcellulose (HPMC) and either sorbitol, mannitol or xylitol at different ratios. The tablets were investigated for their physical properties, ex vivo mucoadhesion, the rate of hydration, gelling efficiency …
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Multifunctional Nanoparticles for Cancer Therapy
… (GMO)-chitosan solid lipid nanoparticles using Poloxamer 407 as a stabilizer. The nanoemulsion was prepared by double emulsion method using ultrasonication. This emulsion was freeze dried. A sensitive UPLC method for simultaneous detection and quantification of both the drugs was successfully …
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High-resolution direct ink writing of soft conductive materials
… possible by incorporating a thermal-sensitive poloxamer (Pluronic F127), which can be removed after the self-supportive polyaniline network forms. In contrast to a polyHEMA-based system, the polyaniline network has a high surface area and porosity while maintaining conductive. The porous nature …
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Isothermale Amplifikationsmethoden für den DNA- und Pyrophosphat-abhängigen Pathogennachweis
… Emulsion wurde durch den Zusatz des Emulgators Poloxamer 188 verbessert. Durch die fluoreszenzmikroskopische Analyse der Emulsion war eine eindeutige Diskriminierung der positiven und negativen Tröpfchen vor allem bei Einsatz von Calcein und Alizarinrot S möglich. Aufgrund des komplexen …
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Nanocarriers for drug targeting and improved bioavailability
… was compared with PRX coarse suspension ODT, PRX/poloxamer 188 physical mixture, bulk PRX samples and a piroxicam commercial ODT (Feldene). All PRX nanocrystals ODT formulations showed a higher drug dissolution rate than coarse PRX ODT. PRX nanocrystals ODT prepared using gelatin or …
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