Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"poliovirus"”.
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Gastrointestinal Influences on Poliovirus Replication, Dissemination and Pathogenesis in Mice
… the intestinal environment on enteric viruses, poliovirus was used as a model enteric virus. Following infection within the GI tract, poliovirus has the capacity to spread to the central nervous system (CNS). Poliovirus infection of the CNS is uncommon, but it can result in acute flaccid …
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Structural Basis For Poliovirus Cloverleaf-Mediated Regulation Of Genome Replication
Poliovirus is a member of the Enterovirus genus, members of which are characterized by small, non-enveloped capsids containing short, positive-sense single-stranded RNA genomes. During the viral replication cycle, it is critical that the virus generates the appropriate amounts of viral proteins and …
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The protein covalently linked to the 5' end of poliovirus RNA.
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Biology, 1979.
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Poliovirus Replication: Interactions with Cytoplasmic Membranes and with Compounds Which Affect Virus Biosynthesis
… altered after infection of HeLa cells with poliovirus. The most striking change is a very large increase in the smooth microsomal membranes with which viral RNA synthesis is associated. These membranes begin to increase between 2.5 and 3.5 hours after infection, and continue to proliferate …
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The removal of low levels of poliovirus from water by coagulation with alum
… a synthetic water seeded with monodispersed poliovirus LScl. Experiments were done using 10(3),10(4),10(6) Plaque Forming Units (PFU) per liter. A microporous filter concentration technique was used post treatment to increase the virus titer to make possible virus enumeration by plaque assay …
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Mechanisms Controlling Virulence Thresholds of Mixed Viral Populations and Identification of Novel Host Barriers to Poliovirus Neuropathogenesis
… including West Nile virus, rabies virus, and poliovirus. Poliovirus, as a model neurotropic virus, is also an RNA virus. RNA viruses have high mutation rates and a propensity to revert attenuating mutations, contributing to disease and complicating treatment and vaccine development. Despite …
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RNA replication by poliovirus RNA-dependent RNA polymerase: effects of residue 5 on elongation complex stability and processivity
The poliovirus (PV) RNA-dependent RNA polymerase (RdRP) is a small, single-subunit, enzyme that is responsible for the replication of the viral genome. PV genome replication is much more involved than just repetitively incorporating a single nucleotide into an oligonucleotide primer. The polymerase …
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Role of basic and hydrophobic residues in the poliovirus polymerase elongation complex and the structure of a coxsackievirus polymerase elongation complex
… residues serve in forming and maintaining the poliovirus (PV) EC and 2) presents the crystal structure of a coxsackievirus (CV) EC. To determine the role of that several arginines, lysines, and tyrosines play in the PV polymerase, we assessed whether mutations to these residues affect …
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Evaluation of an enhanced magneto-chemical process for the removal of pathogens in wastewater
… of the CoMag(TM) process for the removal of MS2, poliovirus type 1, rotavirus strain Wa, and adenovirus type 2 from secondary effluent wastewater, at 24°C and 4°C. Additionally, the removal of MS2 was assessed using a 100 gpm CoMag(TM) pilot plant. The results indicate that there was a …
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eIF4E Phosphorylation Balances Cap-dependent and Cap-independent Translation Initiation
… system, we also analyzed growth of an oncolytic poliovirus, relying purely on cap-independent translation, in the context of varying activity of signaling pathways. Data obtained from this virus helps to confirm that phosphorylation of eIF4E does indeed result in increased cap-independent …
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Host-Based Mechanisms of Ribavirin Resistance: Implications In Treatment Response of Hepatatis C Virus Infection
… host-based RBV resistance on a model RNA virus, poliovirus, HCV replication in cultured hepatoma liver cells, and whether RBV resistance develops in HCV patients. When liver cells permissive for poliovirus or HCV replication were exposed to RBV, resistance developed through reduced activity of …
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Evaluation of bacteriophage and viral persistence during alkaline stabilization in sludge and biosolids intended for land application
… pathogen persistence. The survivability of poliovirus type 1, fecal coliforms, Salmonella, adenovirus type 5, rotavirus Wa, and the male-specific bacteriophage MS-2 was evaluated under lime stabilization conditions in various matrices. Salmonella and fecal coliforms were evaluated at …
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Factors That Influence Mammalian Enteric Virus Infection
… the fecal-oral route. In this work, I used poliovirus, an enteric RNA virus from the Picornaviridae family, as a model system to study mechanisms of RNA virus co-infection and how bacteria influence picornavirus infection. Recent studies determined several modes of RNA virus transmission …
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Characterization of the GBF1-Arf1 axis in enterovirus RNA replication
… many known and emerging pathogens, such as poliovirus, enteroviruses A71 and D68, rhinoviruses, and others. Enterovirus infection induces the massive remodeling of intracellular membranes and the development of specialized domains harboring viral replication complexes, called replication …
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Detection of enteroviruses in marine waters using RT-PCR.
… extract V eluants. Samples were inoculated with poliovirus type 1 (strain LSc-2ab) to evaluate sample inhibition, the effectiveness of column purification and virus recovery efficiency. Samples were subsequently analyzed either by RT-PCR, cell culture or the integrated cell culture/PCR technique. …
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The Applied Epidemiology of Influenza and other Infectious Diseases in Victoria
… in a residential aged care facility; a simulated poliovirus outbreak response to a laboratory containment leak that was conducted by the World Health Organization Western Pacific Regional Office, to maintain response capability within the region; a data analysis of the number of hospitalisations …
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